Antibiotic prophylaxis for hysterectomy and cesarean section

Amoxicillin-clavulanic acid versus cefazolin

Shetty Jyothi, M. Vyas Neetha, Kumar Pratap, Kamath Asha

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section. Method: Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract. Results: Infectious morbidity was found in 11% and 12.5% of hysterectomy patients inAMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (sixAMXCL, four cefazolin, P=0.51) Conclusion: Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalJournal of Obstetrics and Gynecology of India
Volume60
Issue number5
DOIs
Publication statusPublished - 10-2010

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Amoxicillin-Potassium Clavulanate Combination
Cefazolin
Antibiotic Prophylaxis
Hysterectomy
Cesarean Section
Infection
Urinary Tract
Constriction
Fever
Anti-Bacterial Agents
Morbidity

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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title = "Antibiotic prophylaxis for hysterectomy and cesarean section: Amoxicillin-clavulanic acid versus cefazolin",
abstract = "Objective: To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section. Method: Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract. Results: Infectious morbidity was found in 11{\%} and 12.5{\%} of hysterectomy patients inAMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (sixAMXCL, four cefazolin, P=0.51) Conclusion: Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.",
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Antibiotic prophylaxis for hysterectomy and cesarean section : Amoxicillin-clavulanic acid versus cefazolin. / Jyothi, Shetty; Vyas Neetha, M.; Pratap, Kumar; Asha, Kamath.

In: Journal of Obstetrics and Gynecology of India, Vol. 60, No. 5, 10.2010, p. 419-423.

Research output: Contribution to journalArticle

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AU - Jyothi, Shetty

AU - Vyas Neetha, M.

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AU - Asha, Kamath

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N2 - Objective: To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section. Method: Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract. Results: Infectious morbidity was found in 11% and 12.5% of hysterectomy patients inAMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (sixAMXCL, four cefazolin, P=0.51) Conclusion: Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.

AB - Objective: To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section. Method: Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract. Results: Infectious morbidity was found in 11% and 12.5% of hysterectomy patients inAMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (sixAMXCL, four cefazolin, P=0.51) Conclusion: Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.

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