Anticancer activity of 4-[1-oxo-(substituted aryl)-2-propenyl]-3- phenylsydnones

K. Satyanarayana, S.R. Deshpande, B.S. Rao, M.N.A. Rao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Novel structural feature containing 4-[1-oxo-(substituted aryl)-2-propenyl]-3-phenylsydnones were synthesized and screened for anticancer activity. These compounds contain two pharmacophores,a,b unsaturated ketone moiety and sydnone nucleus. Three compounds were synthesized, and all of the three exhibited promising in vitro cytotoxicity in 56 cell lines representing cancers of non-small cell lung, colon, CNS, melanoma, ovarian, prostrate, breast and leukemia. Average growth inhibition of 50% was in the range of 1.7-3.5 μM. Methyl derivative was highly selective against SNB-75 tumor cell line of CNS. It was active at less than one nano mole. However, in vivo the activity was moderate by hollow fiber assay model.
Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume66
Issue number5
Publication statusPublished - 2004

Fingerprint Dive into the research topics of 'Anticancer activity of 4-[1-oxo-(substituted aryl)-2-propenyl]-3- phenylsydnones'. Together they form a unique fingerprint.

  • Cite this