Anticancer activity of stem bark extract and fractions of Wrightia tinctoria in transplantable tumors in mice

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Abstract

Wrightia tinctoria Roxb. (Apocynaceae), widely used in traditional medicine for inflammatory conditions and cancer, has not been studied extensively for its anticancer potential. The present study evaluated the anticancer activity of ethanol extract (EE) and petroleum ether (PE) and ethyl acetate (EA) fractions of stem bark of W. tinctoria using in vivo models. The anticancer activity was evaluated in Dalton’s lymphoma ascites (DLA) solid tumor and Ehrlich’s ascites carcinoma (EAC) liquid tumor models after treatment for 18 and 13 days respectively at 50 and 100 mg/kg i.p. EA at 100 mg/kg was most effective in DLA model with 71.1% inhibition in tumor volume. In EAC model, EA significantly inhibited body weight gain due to liquid tumor (p < 0.05). The mean survival time (MST) increased (p < 0.001) at both doses along with significant improvement in hematological, and antioxidant parameters. W. tinctoria possesses significant anticancer activity and further investigations are in progress to identify the phytochemical and mechanistic basis of action.

Original languageEnglish
Pages (from-to)1995-2000
Number of pages6
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

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Ascites
tumor
bark
Mouse
Tumors
Tumor
stem
acetate
Lymphoma
Apocynaceae
Ehrlich Tumor Carcinoma
Neoplasms
Phytochemicals
Traditional Medicine
Liquid
Tumor Burden
traditional medicine
Antioxidants
liquid
Weight Gain

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

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title = "Anticancer activity of stem bark extract and fractions of Wrightia tinctoria in transplantable tumors in mice",
abstract = "Wrightia tinctoria Roxb. (Apocynaceae), widely used in traditional medicine for inflammatory conditions and cancer, has not been studied extensively for its anticancer potential. The present study evaluated the anticancer activity of ethanol extract (EE) and petroleum ether (PE) and ethyl acetate (EA) fractions of stem bark of W. tinctoria using in vivo models. The anticancer activity was evaluated in Dalton’s lymphoma ascites (DLA) solid tumor and Ehrlich’s ascites carcinoma (EAC) liquid tumor models after treatment for 18 and 13 days respectively at 50 and 100 mg/kg i.p. EA at 100 mg/kg was most effective in DLA model with 71.1{\%} inhibition in tumor volume. In EAC model, EA significantly inhibited body weight gain due to liquid tumor (p < 0.05). The mean survival time (MST) increased (p < 0.001) at both doses along with significant improvement in hematological, and antioxidant parameters. W. tinctoria possesses significant anticancer activity and further investigations are in progress to identify the phytochemical and mechanistic basis of action.",
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AU - Pai, Karkala Sreedhara Ranganath

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AB - Wrightia tinctoria Roxb. (Apocynaceae), widely used in traditional medicine for inflammatory conditions and cancer, has not been studied extensively for its anticancer potential. The present study evaluated the anticancer activity of ethanol extract (EE) and petroleum ether (PE) and ethyl acetate (EA) fractions of stem bark of W. tinctoria using in vivo models. The anticancer activity was evaluated in Dalton’s lymphoma ascites (DLA) solid tumor and Ehrlich’s ascites carcinoma (EAC) liquid tumor models after treatment for 18 and 13 days respectively at 50 and 100 mg/kg i.p. EA at 100 mg/kg was most effective in DLA model with 71.1% inhibition in tumor volume. In EAC model, EA significantly inhibited body weight gain due to liquid tumor (p < 0.05). The mean survival time (MST) increased (p < 0.001) at both doses along with significant improvement in hematological, and antioxidant parameters. W. tinctoria possesses significant anticancer activity and further investigations are in progress to identify the phytochemical and mechanistic basis of action.

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