Anticonvulsant activity of enzyme inhibitors in rats

K. Ramabadran, M. Bansinath, M.N. Guruswami

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Three liver microsomal enzyme inhibitors, proadifen, 2,4‐dichloro‐6‐phenylphenoxyethyldiethylamine, and 2,4‐dichloro‐6‐phenylphenoxyethylamine, and a hepatotoxic agent, carbon tetrachloride, were tested for anticonvulsant activity in adult male albino rats using the maximal electroshock seizure technique. All four substances exhibited significant anticonvulsant activity 1 hr after intraperitoneal administration. This protection was absent when tested 24 hr later. Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company
Original languageEnglish
Pages (from-to)1245-1246
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume65
Issue number8
DOIs
Publication statusPublished - 1976
Externally publishedYes

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