Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats

A. Shirwaikar, K. Rajendran, I.S.R. Punitha

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. © 2004 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalJournal of Ethnopharmacology
Volume97
Issue number2
DOIs
Publication statusPublished - 2005

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Niacinamide
Streptozocin
Hypoglycemic Agents
Systems Analysis
Menispermaceae
Ayurvedic Medicine
Liver Glycogen
Body Weight Changes
Thiobarbituric Acid Reactive Substances
Glycosylated Hemoglobin A
Traditional Medicine
Medicinal Plants
Serum
Ireland
Blood Glucose
Fasting
Diabetes Mellitus
Insulin
Lipids
Therapeutics

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@article{c1cce5960f424f3b85ca656ed34151b6,
title = "Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats",
abstract = "The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. {\circledC} 2004 Elsevier Ireland Ltd. All rights reserved.",
author = "A. Shirwaikar and K. Rajendran and I.S.R. Punitha",
note = "Cited By :97 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal Coll. of Pharmaceutical Sci., Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: glycosylated hemoglobin, 9062-63-9; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4 References: Standards of medical care for patients with diabetes mellitus (1998) Diabetes Care, 21, pp. 22-31. , American Diabetes Association; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Chinnaiah, A., (2002) 1000 Siddha Medicine Notes (Tamil), , Siva Publishers Sivakasi; Datta, S.C., Mathur, R.K., Baruah, J.N., Minor alkaloids from Coscinium fenestratum root (1988) Indian Drugs, 25, p. 350; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, , Scientific Book Agency Calcutta; Gingsberg, H.N., Lipoprotein metabolism and its relationship to atheroscelrosis (1994) Medicinal and Clinical North America, 78, pp. 1-20; Grover, J.K., Vats, V., Rathi, S.S., Antihyperglycemic effects of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism (2000) Journal of Ethnopharmacology, 73, pp. 461-470; Hannan, J.M.A., Rokeya, B., Faruque, O., Nahar, N., Mosihuzzaman, M., Azad Khan, A.K., Ali, L., Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status in type 2 diabetic model rats (2003) Journal of Ethnopharmacology, 88, pp. 73-77; Harborne, J.B., (1998) Phytochemical Methods, , Chapman & Hall London; Jouad, H., Lemhadri, A., Maghrani, M., Ali Zeggwah, N., Eddouks, M., Cholesterol lowering activity of the aqueous extract of Spergularia in normal and recent onset diabetic rats (2003) Journal of Ethnopharmacology, 87, pp. 43-49; Kalavincela, T., (1998) Studies on Rural Medicine of Kanyakumari District with Special Reference to Medicinal Plants, p. 185. , M.Phil Thesis, Manonmaniam Sundranar University; Khan, B.A., Abraham, A., Leelamma, S., Hypoglycemic action of Murraya koenigii (curry leaf), Brassica juncea (mustard); Mechanism of action (1995) Indian Journal of Biochemistry and Biophysics, 32, pp. 106-108; Kokate, C.K., (1994) Practical Pharmacognosy, , Vallabh Prakashan New Delhi; Latner, A., (1958) Clinical Biochemistry, , Saunders Philadelphia; Luc, G., Fruchart, J.C., Oxidation of lipoproteins and atherosclerosis (1991) American Journal of Clinical Nutrition, 53, pp. 2065-2095; Maghrani, M., Lemhadri, A., Jouad, H., Michel, J.-B., Eddouks, M., Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats (2003) Journal of Ethnopharmacology, 87, pp. 21-25; Mahapatra, B., Hypoglycemic activity of Coscinium fenestratum (1997) Journal of Research in Ayurveda and Siddha, 18, p. 89; Malhotra, S., Taneja, S.C., Dhar, K.L., Minor alkaloid from Coscinium fenestratum (1989) Phytochemistry, 28, pp. 1998-1999; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Mitra, S.K., Gopumadhavan, S., Muralidhar, T.S., Anturlikar, S.D., Sujatha, M.B., Effect of D-400, a herbomineral preparation on lipid profile, glycated hemoglobin and glucose tolerance in STZ induced diabetes in rats (1995) Indian Journal of Experimental Biology, 33, pp. 798-800; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Indian Journal of Biological Chemistry, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 95, pp. 351-358; Prasannan, K.G., Subrahmanyam, K., Effects of insulin on the glycogen synthesis in vivo in the brain and liver of rats under different conditions (1965) Indian Journal of Medical Research, 53, p. 1003; Ram, A., Lauria, P., Gupta, R., Kumar, P., Sharma, V.N., Hypocholesterolemic effects of Terminalia arjuna tree bark (1997) Journal of Ethnopharmacology, 55, pp. 165-169; Sachdewa, A., Khemani, L.D., Effect of Hibiscus rosa sinensis Linn. Ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) Journal of Ethnopharmacology, 89, pp. 61-66; Sharma, S.R., Dwivedi, S.K., Swarup, D., Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia sylvestre seeds in rats (1997) Journal of Ethnopharmacology, 58, pp. 39-44; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) Journal of Ethnopharmacology, 38, pp. 151-155; Suresh Kumar, J.S., Menon, V.P., Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain (1993) Metabolism, 42, pp. 1435-1439; Swanston-Flat, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; Wealth Of India, T., Coscinium fenestratum (1950) A Dictionary of Indian Raw Materials and Industrial Products, , CSIR Delhi, India; Turner, M.A., (1965) Screening Methods in Pharmacology, , Academic Press New York; Varier, P.S., (1994) Indian Medicinal Plants Compendium of 500 Species, 2. , Orient Longmann Ltd. Hyderabad; Venkateswaran, S., Pari, L., Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats (2003) Journal of Ethnopharmacology, 84, pp. 163-168; Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., Cheng, J., Effects of berberine on glucose metabolism in vitro (2002) Metabolism, 51, pp. 1439-1443",
year = "2005",
doi = "10.1016/j.jep.2004.11.034",
language = "English",
volume = "97",
pages = "369--374",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. / Shirwaikar, A.; Rajendran, K.; Punitha, I.S.R.

In: Journal of Ethnopharmacology, Vol. 97, No. 2, 2005, p. 369-374.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats

AU - Shirwaikar, A.

AU - Rajendran, K.

AU - Punitha, I.S.R.

N1 - Cited By :97 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal Coll. of Pharmaceutical Sci., Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: glycosylated hemoglobin, 9062-63-9; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4 References: Standards of medical care for patients with diabetes mellitus (1998) Diabetes Care, 21, pp. 22-31. , American Diabetes Association; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Chinnaiah, A., (2002) 1000 Siddha Medicine Notes (Tamil), , Siva Publishers Sivakasi; Datta, S.C., Mathur, R.K., Baruah, J.N., Minor alkaloids from Coscinium fenestratum root (1988) Indian Drugs, 25, p. 350; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, , Scientific Book Agency Calcutta; Gingsberg, H.N., Lipoprotein metabolism and its relationship to atheroscelrosis (1994) Medicinal and Clinical North America, 78, pp. 1-20; Grover, J.K., Vats, V., Rathi, S.S., Antihyperglycemic effects of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism (2000) Journal of Ethnopharmacology, 73, pp. 461-470; Hannan, J.M.A., Rokeya, B., Faruque, O., Nahar, N., Mosihuzzaman, M., Azad Khan, A.K., Ali, L., Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status in type 2 diabetic model rats (2003) Journal of Ethnopharmacology, 88, pp. 73-77; Harborne, J.B., (1998) Phytochemical Methods, , Chapman & Hall London; Jouad, H., Lemhadri, A., Maghrani, M., Ali Zeggwah, N., Eddouks, M., Cholesterol lowering activity of the aqueous extract of Spergularia in normal and recent onset diabetic rats (2003) Journal of Ethnopharmacology, 87, pp. 43-49; Kalavincela, T., (1998) Studies on Rural Medicine of Kanyakumari District with Special Reference to Medicinal Plants, p. 185. , M.Phil Thesis, Manonmaniam Sundranar University; Khan, B.A., Abraham, A., Leelamma, S., Hypoglycemic action of Murraya koenigii (curry leaf), Brassica juncea (mustard); Mechanism of action (1995) Indian Journal of Biochemistry and Biophysics, 32, pp. 106-108; Kokate, C.K., (1994) Practical Pharmacognosy, , Vallabh Prakashan New Delhi; Latner, A., (1958) Clinical Biochemistry, , Saunders Philadelphia; Luc, G., Fruchart, J.C., Oxidation of lipoproteins and atherosclerosis (1991) American Journal of Clinical Nutrition, 53, pp. 2065-2095; Maghrani, M., Lemhadri, A., Jouad, H., Michel, J.-B., Eddouks, M., Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats (2003) Journal of Ethnopharmacology, 87, pp. 21-25; Mahapatra, B., Hypoglycemic activity of Coscinium fenestratum (1997) Journal of Research in Ayurveda and Siddha, 18, p. 89; Malhotra, S., Taneja, S.C., Dhar, K.L., Minor alkaloid from Coscinium fenestratum (1989) Phytochemistry, 28, pp. 1998-1999; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Mitra, S.K., Gopumadhavan, S., Muralidhar, T.S., Anturlikar, S.D., Sujatha, M.B., Effect of D-400, a herbomineral preparation on lipid profile, glycated hemoglobin and glucose tolerance in STZ induced diabetes in rats (1995) Indian Journal of Experimental Biology, 33, pp. 798-800; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Indian Journal of Biological Chemistry, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 95, pp. 351-358; Prasannan, K.G., Subrahmanyam, K., Effects of insulin on the glycogen synthesis in vivo in the brain and liver of rats under different conditions (1965) Indian Journal of Medical Research, 53, p. 1003; Ram, A., Lauria, P., Gupta, R., Kumar, P., Sharma, V.N., Hypocholesterolemic effects of Terminalia arjuna tree bark (1997) Journal of Ethnopharmacology, 55, pp. 165-169; Sachdewa, A., Khemani, L.D., Effect of Hibiscus rosa sinensis Linn. Ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) Journal of Ethnopharmacology, 89, pp. 61-66; Sharma, S.R., Dwivedi, S.K., Swarup, D., Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia sylvestre seeds in rats (1997) Journal of Ethnopharmacology, 58, pp. 39-44; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) Journal of Ethnopharmacology, 38, pp. 151-155; Suresh Kumar, J.S., Menon, V.P., Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain (1993) Metabolism, 42, pp. 1435-1439; Swanston-Flat, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; Wealth Of India, T., Coscinium fenestratum (1950) A Dictionary of Indian Raw Materials and Industrial Products, , CSIR Delhi, India; Turner, M.A., (1965) Screening Methods in Pharmacology, , Academic Press New York; Varier, P.S., (1994) Indian Medicinal Plants Compendium of 500 Species, 2. , Orient Longmann Ltd. Hyderabad; Venkateswaran, S., Pari, L., Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats (2003) Journal of Ethnopharmacology, 84, pp. 163-168; Yin, J., Hu, R., Chen, M., Tang, J., Li, F., Yang, Y., Cheng, J., Effects of berberine on glucose metabolism in vitro (2002) Metabolism, 51, pp. 1439-1443

PY - 2005

Y1 - 2005

N2 - The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. © 2004 Elsevier Ireland Ltd. All rights reserved.

AB - The antidiabetic potential of the alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the STZ-nicotinamide induced type 2 diabetic model. Graded doses of the alcoholic stem extract were administered to normal and experimental diabetic rats for 12 days. Significant (p <0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. In addition, changes in body weight, serum lipid profiles, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels assessed in the extract treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine. © 2004 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.jep.2004.11.034

DO - 10.1016/j.jep.2004.11.034

M3 - Article

VL - 97

SP - 369

EP - 374

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2

ER -