Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats

A. Shirwaikar, K. Rajendran, C.D. Kumar, R. Bodla

Research output: Contribution to journalArticlepeer-review

171 Citations (Scopus)

Abstract

The claim by some tribal populations in parts of Northern India that the young leaves of the custard apple tree, Annona squamosa L. (Annonaceae) has antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin-nicotinamide and graded doses of the aqueous leaf extracts were then administered in drinking water to normal and experimental diabetic rats for 12 days. Fasting plasma glucose levels, serum insulin levels, serum lipid profiles and changes in body weight were evaluated in normal rats while liver glycogen levels and pancreatic TBARS levels were evaluated additionally in diabetic rats. The diabetic groups treated with the aqueous leaf extract were compared with standard glibenclamide. The findings of the study support the antidiabetic claims of Annona squamosa. © 2004 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJournal of Ethnopharmacology
Volume91
Issue number1
DOIs
Publication statusPublished - 2004

Fingerprint Dive into the research topics of 'Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats'. Together they form a unique fingerprint.

Cite this