@article{4bde1bf9b30f4e83a4b45a13042ae45c,
title = "Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats",
abstract = "The claim by some tribal populations in parts of Northern India that the young leaves of the custard apple tree, Annona squamosa L. (Annonaceae) has antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin-nicotinamide and graded doses of the aqueous leaf extracts were then administered in drinking water to normal and experimental diabetic rats for 12 days. Fasting plasma glucose levels, serum insulin levels, serum lipid profiles and changes in body weight were evaluated in normal rats while liver glycogen levels and pancreatic TBARS levels were evaluated additionally in diabetic rats. The diabetic groups treated with the aqueous leaf extract were compared with standard glibenclamide. The findings of the study support the antidiabetic claims of Annona squamosa. {\textcopyright} 2004 Elsevier Ireland Ltd. All rights reserved.",
author = "A. Shirwaikar and K. Rajendran and C.D. Kumar and R. Bodla",
note = "Cited By :129 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; insulin, 9004-10-8; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4 References: Ajabnoor, M., Effect of aloes on blood glucose levels in normal and alloxan diabetic mice (1990) Journal of Ethnopharmacology, 28, pp. 215-220; Asolkar, L.V., Kakkar, K.K., Chakre, O.J., (1992) Glossary of Indian Medicinal Plants with Active Principles, pp. 72-73. , Publications and Information Directorate, New Delhi; Atal, C.K., Zutshi, U., Rao, P.G., Scientific evidence on the role of ayurvedic herbals on bioavailability of drugs (1981) Journal of Ethnopharmacology, 4, pp. 229-232; Atique, A., Iqbal, M., Ghouse, A.K.M., Use of Annona squamosa and Piper nigrum against diabetes (1985) Fitoterapia, 56, pp. 190-192; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Chase, P.H., Glasgow, A.M., Juvenile diabetes mellitus and serum lipids and lipoprotein levels (1976) American Journal of Diseases of Child, 130, p. 1113; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, p. 153. , Scientific Book Agency, Calcutta; Halliwell, B., Gutteridge, J.M.C., (1985) Free Radicals in Biology and Medicine, pp. 24-86. , Oxford Clarendon Press, London; Harborne, J.B., (1998) Phytochemical Methods, pp. 60-66. , Chapman & Hall, London; Hiroshi, O., Nobuko, O., Kunio, V., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 5, p. 351; Huang, X., Vaag, A., Hanson, M., Weng, J., Goop, L., Impaired insulin stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited (2000) Journal of Clinical Endocrinology and Metabolism, 85, p. 1584; John, W.B., Role of oxidative stress in development of complications in diabetes (1991) Diabetes, 40, p. 405; Kokate, C.K., (1994) Practical Pharmacognosy, pp. 107-113. , Vallabh Prakashan, New Delhi; Latner, A., (1958) Clinical Biochemistry, p. 48. , Saunders, Philadelphia; Majeed, M., Badmeev, V., Rajendran, R., (1998) Piperine as Bioavailability Enhancer, , US Patent 5,744,161; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Indian Journal of Biological Chemistry, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Pellegrino, M., Christophe, B., Rene, G., Michele, R., Michele, M., Dominique, H.-B., Michela, N., Gerard, R., Development of a new model of type II diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Rao, V.S.N., Dasaradhan, P., Krishnaiah, K.S., Antifertility effect of some indigenous plants (1979) Indian Journal of Medical Research, 70, pp. 517-520; Riyad, M.A., Abdul Salam, S.A., Mohammad, S.S., Effect of fenugreek and lupine seeds on the development of experimental diabetes in rats (1988) Planta Medica, 54, pp. 286-290; Sunanda, P., Anand, K., Possible amelioration of hyperthyroidism by the leaf extract of Annona squamosa (2003) Current Science, 84, pp. 1402-1404; Swanston-Flatt, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatments for diabetes: Studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; Topno, K.K., Plants used by tribals of Chotanagpur against diabetes (1997) Botanica, 47, pp. 99-101; Turner, M.A., (1965) Screening Methods in Pharmacology, p. 26. , Academic Press, New York; Whitton, P.D., Hems, D.A., Glycogen synthesis in perfused liver of streptozotocin diabetic rats (1975) Biochemical Journal, 150, p. 153; Williams, J.B., Adverse effects of thyroid hormones (1997) Drugs Aging, 11, pp. 171-460; Ye, F., Shen, Z., Xie, M., Alpha glucosidase inhibition from a Chinese medicinal herb (Ramulus mori) in normal and diabetic rats and mice (2002) Phytomedicine, 9, pp. 161-166",
year = "2004",
doi = "10.1016/j.jep.2003.12.017",
language = "English",
volume = "91",
pages = "171--175",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1",
}
