Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids

M. K. Unnikrishnan, Veeresh Veerapur, Yogendra Nayak, Piya Paul Mudgal, Geetha Mathew

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)

Abstract

Environmental and lifestyle changes contribute to the increasing global incidence of metabolic pathologies. None of the available marketed drugs comprehensively tackle the complexities associated with the axis linking inflammation/insulin resistance with obesity/hyperlipidemia. Flavonoids, found ubiquitously in most edible vegetables and fruits and constituting a major portion of micronutrients in diet, have emerged as potential alternatives for treating diabetes, hyperlipidemia and oxidative stress, involving multiple signaling pathways. Active components in a flavonoid-rich diet act synergistically on different biochemical pathways, bringing about a comprehensive therapeutic effect. Clinical evidences support the usefulness of flavonoid-rich foods over supplementation with individual flavonoids in high doses. The pleiotropic nature of flavonoids demonstrates a strong basis for their multi-targeted action on metabolic pathology. As more and more drugs focusing on single targets are being withdrawn, possibly because they destabilize the delicate equilibrium in the complex metabolic network, research on flavonoids is pacing ahead towards targeting multiple pathways holistically, legitimizing the need for re-establishing the metabolic homeostasis.

Original languageEnglish
Title of host publicationPolyphenols in Human Health and Disease
PublisherElsevier Inc.
Pages143-161
Number of pages19
Volume1
ISBN (Print)9780123984562
DOIs
Publication statusPublished - 11-2013

Fingerprint

Hypolipidemic Agents
Hypoglycemic Agents
Flavonoids
Antioxidants
Hyperlipidemias
Pathology
Diet
Micronutrients
Therapeutic Uses
Dietary Supplements
Metabolic Networks and Pathways
Pharmaceutical Preparations
Vegetables
Insulin Resistance
Life Style
Fruit
Oxidative Stress
Homeostasis
Obesity
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Dentistry(all)

Cite this

Unnikrishnan, M. K., Veerapur, V., Nayak, Y., Mudgal, P. P., & Mathew, G. (2013). Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids. In Polyphenols in Human Health and Disease (Vol. 1, pp. 143-161). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398456-2.00013-X
Unnikrishnan, M. K. ; Veerapur, Veeresh ; Nayak, Yogendra ; Mudgal, Piya Paul ; Mathew, Geetha. / Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids. Polyphenols in Human Health and Disease. Vol. 1 Elsevier Inc., 2013. pp. 143-161
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Unnikrishnan, MK, Veerapur, V, Nayak, Y, Mudgal, PP & Mathew, G 2013, Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids. in Polyphenols in Human Health and Disease. vol. 1, Elsevier Inc., pp. 143-161. https://doi.org/10.1016/B978-0-12-398456-2.00013-X

Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids. / Unnikrishnan, M. K.; Veerapur, Veeresh; Nayak, Yogendra; Mudgal, Piya Paul; Mathew, Geetha.

Polyphenols in Human Health and Disease. Vol. 1 Elsevier Inc., 2013. p. 143-161.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Unnikrishnan MK, Veerapur V, Nayak Y, Mudgal PP, Mathew G. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids. In Polyphenols in Human Health and Disease. Vol. 1. Elsevier Inc. 2013. p. 143-161 https://doi.org/10.1016/B978-0-12-398456-2.00013-X