Antidiabetic effect through islet cell protection in streptozotocin diabetes: A preliminary assessment of two thiazolidin-4-ones in Swiss albino mice

Anoop Kishore, Gopalan Kutty Nampurath, Suma P. Mathew, Robby T. Zachariah, Bhagath Kumar Potu, Muddanna S. Rao, Manna Valiathan, Mallikarjuna Rao Chamallamudi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study was undertaken on the basis of several reports in the literature that pancreatic beta cells are capable of replication/regeneration and also being afforded protection against damage induced by streptozotocin. Nicotinamide was reported to give protection against streptozotocin-induced damage in rats. In the present study, two thiazolidine-4-ones with nicotinamide substitution were administered to Swiss albino mice with streptozotocin diabetes for 15 days. Concurrently, one group received nicotinic acid. Both the test compounds reversed the hyperglycaemia diabetic mice. Damage to pancreatic islets was also reduced in these groups compared to diabetic control and nicotinic acid treated groups. Since these compounds have been earlier found have antioxidant activity, one of the possible mechanisms of action could be by reducing oxidative stress in pancreas. Further, possibly by releasing nicotinamide in vivo, the molecules could have contributed to the NAD pool in pancreas and afforded protection. It is concluded that the test compounds have potential to be developed for multiple beneficial action in conditions like metabolic syndrome.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalChemico-Biological Interactions
Volume177
Issue number3
DOIs
Publication statusPublished - 12-02-2009

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Cytoprotection
Niacinamide
Experimental Diabetes Mellitus
Streptozocin
Medical problems
Islets of Langerhans
Hypoglycemic Agents
Niacin
Pancreas
Thiazolidines
Oxidative stress
Insulin-Secreting Cells
Hyperglycemia
NAD
Rats
Regeneration
Oxidative Stress
Substitution reactions
Antioxidants
Molecules

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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Antidiabetic effect through islet cell protection in streptozotocin diabetes : A preliminary assessment of two thiazolidin-4-ones in Swiss albino mice. / Kishore, Anoop; Nampurath, Gopalan Kutty; Mathew, Suma P.; Zachariah, Robby T.; Potu, Bhagath Kumar; Rao, Muddanna S.; Valiathan, Manna; Chamallamudi, Mallikarjuna Rao.

In: Chemico-Biological Interactions, Vol. 177, No. 3, 12.02.2009, p. 242-246.

Research output: Contribution to journalArticle

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