Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats

V.P. Veerapur, K.R. Prabhakar, V.K. Parihar, P. Bansal, K.K. Srinivasan, K.I. Priyadarsini, M.K. Unnikrishnan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.
Original languageUndefined/Unknown
Pages (from-to)59-70
Number of pages12
JournalInternational Journal of Phytomedicine
Volume2
Issue number1
DOIs
Publication statusPublished - 2010

Cite this

Veerapur, V. P., Prabhakar, K. R., Parihar, V. K., Bansal, P., Srinivasan, K. K., Priyadarsini, K. I., & Unnikrishnan, M. K. (2010). Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats. International Journal of Phytomedicine, 2(1), 59-70. https://doi.org/10.5138/ijpm.2010.0975.0185.02011
Veerapur, V.P. ; Prabhakar, K.R. ; Parihar, V.K. ; Bansal, P. ; Srinivasan, K.K. ; Priyadarsini, K.I. ; Unnikrishnan, M.K. / Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats. In: International Journal of Phytomedicine. 2010 ; Vol. 2, No. 1. pp. 59-70.
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abstract = "We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16{\%} and 72.9{\%} respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.",
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Veerapur, VP, Prabhakar, KR, Parihar, VK, Bansal, P, Srinivasan, KK, Priyadarsini, KI & Unnikrishnan, MK 2010, 'Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats', International Journal of Phytomedicine, vol. 2, no. 1, pp. 59-70. https://doi.org/10.5138/ijpm.2010.0975.0185.02011

Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats. / Veerapur, V.P.; Prabhakar, K.R.; Parihar, V.K.; Bansal, P.; Srinivasan, K.K.; Priyadarsini, K.I.; Unnikrishnan, M.K.

In: International Journal of Phytomedicine, Vol. 2, No. 1, 2010, p. 59-70.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats

AU - Veerapur, V.P.

AU - Prabhakar, K.R.

AU - Parihar, V.K.

AU - Bansal, P.

AU - Srinivasan, K.K.

AU - Priyadarsini, K.I.

AU - Unnikrishnan, M.K.

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PY - 2010

Y1 - 2010

N2 - We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.

AB - We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.

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DO - 10.5138/ijpm.2010.0975.0185.02011

M3 - Article

VL - 2

SP - 59

EP - 70

JO - International Journal of Phytomedicine

JF - International Journal of Phytomedicine

SN - 0975-0185

IS - 1

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