Antigen-specific suppression of inflammatory arthritis using liposomes

Christelle Capini, Montree Jaturanpinyo, Hsin I. Chang, Srinivas Mutalik, Alice McNally, Shayna Street, Raymond Steptoe, Brendan O'Sullivan, Nigel Davies, Ranjeny Thomas

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with Ag (OVA or methylated BSA) and a lipophilic NF-κB inhibitor (curcumin, quercetin, or Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. We injected loaded liposomes into mice primed with Ag or into mice suffering from Ag-induced inflammatory arthritis. The liposomes targeted APCs in situ, suppressing the cells' responsiveness to NF-κB and inducing Ag-specific FoxP3+ regulatory T cells. This regulatory mechanism suppressed effector T cell responses and the clinical signs of fullblown Ag-induced arthritis. Thus, liposomes encapsulate Ags and NF-κB inhibitors stably and efficiently and could be readily adapted to deliver Ags and inhibitors for Ag-specific suppression of other autoimmune and allergic diseases.

Original languageEnglish
Pages (from-to)3556-3565
Number of pages10
JournalJournal of Immunology
Volume182
Issue number6
DOIs
Publication statusPublished - 15-03-2009

Fingerprint

Liposomes
Arthritis
Antigens
Autoimmune Diseases
Curcumin
Quercetin
Regulatory T-Lymphocytes
Phosphatidylcholines
Ovum
Rheumatoid Arthritis
T-Lymphocytes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Capini, C., Jaturanpinyo, M., Chang, H. I., Mutalik, S., McNally, A., Street, S., ... Thomas, R. (2009). Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology, 182(6), 3556-3565. https://doi.org/10.4049/jimmunol.0802972
Capini, Christelle ; Jaturanpinyo, Montree ; Chang, Hsin I. ; Mutalik, Srinivas ; McNally, Alice ; Street, Shayna ; Steptoe, Raymond ; O'Sullivan, Brendan ; Davies, Nigel ; Thomas, Ranjeny. / Antigen-specific suppression of inflammatory arthritis using liposomes. In: Journal of Immunology. 2009 ; Vol. 182, No. 6. pp. 3556-3565.
@article{1b7407cc6d754d5aae74fd4ee0adcb43,
title = "Antigen-specific suppression of inflammatory arthritis using liposomes",
abstract = "Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with Ag (OVA or methylated BSA) and a lipophilic NF-κB inhibitor (curcumin, quercetin, or Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. We injected loaded liposomes into mice primed with Ag or into mice suffering from Ag-induced inflammatory arthritis. The liposomes targeted APCs in situ, suppressing the cells' responsiveness to NF-κB and inducing Ag-specific FoxP3+ regulatory T cells. This regulatory mechanism suppressed effector T cell responses and the clinical signs of fullblown Ag-induced arthritis. Thus, liposomes encapsulate Ags and NF-κB inhibitors stably and efficiently and could be readily adapted to deliver Ags and inhibitors for Ag-specific suppression of other autoimmune and allergic diseases.",
author = "Christelle Capini and Montree Jaturanpinyo and Chang, {Hsin I.} and Srinivas Mutalik and Alice McNally and Shayna Street and Raymond Steptoe and Brendan O'Sullivan and Nigel Davies and Ranjeny Thomas",
year = "2009",
month = "3",
day = "15",
doi = "10.4049/jimmunol.0802972",
language = "English",
volume = "182",
pages = "3556--3565",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "6",

}

Capini, C, Jaturanpinyo, M, Chang, HI, Mutalik, S, McNally, A, Street, S, Steptoe, R, O'Sullivan, B, Davies, N & Thomas, R 2009, 'Antigen-specific suppression of inflammatory arthritis using liposomes', Journal of Immunology, vol. 182, no. 6, pp. 3556-3565. https://doi.org/10.4049/jimmunol.0802972

Antigen-specific suppression of inflammatory arthritis using liposomes. / Capini, Christelle; Jaturanpinyo, Montree; Chang, Hsin I.; Mutalik, Srinivas; McNally, Alice; Street, Shayna; Steptoe, Raymond; O'Sullivan, Brendan; Davies, Nigel; Thomas, Ranjeny.

In: Journal of Immunology, Vol. 182, No. 6, 15.03.2009, p. 3556-3565.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antigen-specific suppression of inflammatory arthritis using liposomes

AU - Capini, Christelle

AU - Jaturanpinyo, Montree

AU - Chang, Hsin I.

AU - Mutalik, Srinivas

AU - McNally, Alice

AU - Street, Shayna

AU - Steptoe, Raymond

AU - O'Sullivan, Brendan

AU - Davies, Nigel

AU - Thomas, Ranjeny

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with Ag (OVA or methylated BSA) and a lipophilic NF-κB inhibitor (curcumin, quercetin, or Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. We injected loaded liposomes into mice primed with Ag or into mice suffering from Ag-induced inflammatory arthritis. The liposomes targeted APCs in situ, suppressing the cells' responsiveness to NF-κB and inducing Ag-specific FoxP3+ regulatory T cells. This regulatory mechanism suppressed effector T cell responses and the clinical signs of fullblown Ag-induced arthritis. Thus, liposomes encapsulate Ags and NF-κB inhibitors stably and efficiently and could be readily adapted to deliver Ags and inhibitors for Ag-specific suppression of other autoimmune and allergic diseases.

AB - Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with Ag (OVA or methylated BSA) and a lipophilic NF-κB inhibitor (curcumin, quercetin, or Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. We injected loaded liposomes into mice primed with Ag or into mice suffering from Ag-induced inflammatory arthritis. The liposomes targeted APCs in situ, suppressing the cells' responsiveness to NF-κB and inducing Ag-specific FoxP3+ regulatory T cells. This regulatory mechanism suppressed effector T cell responses and the clinical signs of fullblown Ag-induced arthritis. Thus, liposomes encapsulate Ags and NF-κB inhibitors stably and efficiently and could be readily adapted to deliver Ags and inhibitors for Ag-specific suppression of other autoimmune and allergic diseases.

UR - http://www.scopus.com/inward/record.url?scp=65449183747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65449183747&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.0802972

DO - 10.4049/jimmunol.0802972

M3 - Article

VL - 182

SP - 3556

EP - 3565

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 6

ER -

Capini C, Jaturanpinyo M, Chang HI, Mutalik S, McNally A, Street S et al. Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology. 2009 Mar 15;182(6):3556-3565. https://doi.org/10.4049/jimmunol.0802972