Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats

A. Shirwaikar, K. Rajendran, I.S.R. Punitha

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The antihyperglycemic potential of the aqueous stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the aqueous stem extract were administered to normal and experimental diabetic rats for 12 days. In extract-treated diabetic rats, an insulin-independent action with significant reduction in blood glucose, serum triglyceride, and cholesterol levels was observed. In addition, other parameters like change in body weight, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels, assessed in the extract-treated diabetic rats, were compared with diabetic control and normal animals. Significant results were observed in the above parameters thereby justifying the use of the plant in the indigenous system of medicine. © 2005 Taylor & Francis Ltd.
Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalPharmaceutical Biology
Volume43
Issue number8
DOIs
Publication statusPublished - 2005

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Hypoglycemic Agents
Systems Analysis
Menispermaceae
Ayurvedic Medicine
Liver Glycogen
Body Weight Changes
Niacinamide
Thiobarbituric Acid Reactive Substances
Glycosylated Hemoglobin A
Traditional Medicine
Medicinal Plants
Streptozocin
Blood Glucose
Diabetes Mellitus
Triglycerides
Cholesterol
Insulin
Serum
Therapeutics

Cite this

Shirwaikar, A. ; Rajendran, K. ; Punitha, I.S.R. / Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats. In: Pharmaceutical Biology. 2005 ; Vol. 43, No. 8. pp. 707-712.
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title = "Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats",
abstract = "The antihyperglycemic potential of the aqueous stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the aqueous stem extract were administered to normal and experimental diabetic rats for 12 days. In extract-treated diabetic rats, an insulin-independent action with significant reduction in blood glucose, serum triglyceride, and cholesterol levels was observed. In addition, other parameters like change in body weight, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels, assessed in the extract-treated diabetic rats, were compared with diabetic control and normal animals. Significant results were observed in the above parameters thereby justifying the use of the plant in the indigenous system of medicine. {\circledC} 2005 Taylor & Francis Ltd.",
author = "A. Shirwaikar and K. Rajendran and I.S.R. Punitha",
note = "Cited By :15 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: cholesterol, 57-88-5; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; streptozocin, 18883-66-4 References: Bainton, D., Miller, N.E., Botton, C.H., Yarnell, J.W.G., Suretman, P.M., Baker, I.A., Lewis, B., Elwood, P.C., Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men (1992) Br Heart J, 68, pp. 60-66; Berrogui, H., Ettaib, A., Herrera Gonzalez, M.D., Alvarez De Sotomayor, M., Bennani-Kabchi, N., Hmamouchi, M., Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in meriones shawi rats (2003) J Ethnopharmacol, 89, pp. 15-18; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Burcelin, R., Eddouks, M., Maury, J., Kande, J., Assan, R., Girard, J., Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin diabetic rats (1995) Diabetologia, 38, pp. 283-290; Chinnaiah, A., (2002) 1000 Siddha Medicine Notes (Tamil), 1st Ed., p. 33. , Sivakasi, Tamilnadu, India, Siva Publishers; Dwivedi, S., Agarwal, M.P., Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug in coronary artery disease (1994) J Assoc Physicians India, 42, pp. 287-289; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, 2, pp. 153-158. , Calcutta, Scientific Book Agency; Hannan, J.M.A., Rokeya, B., Faruque, O., Nahar, N., Mosihuzzaman, M., Azad Khan, A.K., Ali, L., Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status in type 2 diabetic model rats (2003) J Ethnopharmacol, 88, pp. 73-77; Harborne, J.B., (1998) Phytochemical Methods, pp. 60-66. , London, Chapman & Hall; Hostettman, K., Marston, A., (1995) Saponins, pp. 232-286. , Cambridge, Cambridge University Press; Howard, B.V., James Howard, W.M., The pathophysiology and treatment of lipid disorders in diabetes mellitus (1994) Joslin's Diabetes Mellitus, 13th Ed., p. 372. , Philadelphia, Lea & Febiger; Huang, X., Vaag, A., Hanson, M., Weng, J., Goop, L., Impaired insulin stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients in acquired rather than inherited (2000) Clin Endocrin Metabol, 85, p. 1584; Jackson, Rl., Hess, R.L., England, J.D., Hb1c values in children with over diabetes maintained in varying degree (1979) Diabetes Care, 2, pp. 391-395; Jouad, H., Lemhadri, A., Maghrani, M., Ali Zeggwah, N., Eddouks, M., Cholesterol lowering activity of the aqueous extract of Spergularia in normal and recent onset diabetic rats (2003) J Ethnopharmacol, 87, pp. 43-49; Kalavincela, T., (1998) Studies on Rural Medicine of Kanyakumari District with Special Reference to Medicinal Plants, p. 185. , M. Phil. Thesis, Manonmaniam Sundranar University, Tirunelveli, Tamilnadu, India; Koenig, R.J., Peterson, C.M., Jones, R.L., Saudek, C., Lehrman, M., Cerami, A., Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus (1976) New Engl J Med, 295, pp. 417-420; Kokate, C.K., (1994) Practical Pharmacognosy, pp. 107-113. , New Delhi, Vallabh Prakashan; Ladeji, O., Omekaran, I., Solomon, M., Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in STZ induced diabetic rats (2003) J Ethnopharmacol, 84, pp. 139-142; Lowry, O.H., Rosenburgh, N.J., Farr, A.L., Randall, R.L., Protein measurement with Folin-phenol reagent (1951) J Biol Chem, 193, pp. 265-275; Mahapatra, B., Hypoglycemic activity of Coscinium fenestratum (1997) J Res Ayu Siddha, 18, p. 89; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Second report of the expert panel on detection, evaluation and treatment of high blood cholesterol in adults (1994) Circulation, 89, pp. 1329-1450; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Ind J Biol Chem, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Anal Biochem, 95, pp. 351-358; Ram, A., Lauria, P., Gupta, R., Kumar, P., Sharma, V.N., Hypocholesterolemic effects of Terminalia arjuna tree bark (1997) J Ethnopharmacol, 55, pp. 165-169; Sachdewa, A., Khemani, L.D., Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) J Ethnopharmacol, 89, pp. 61-66; Sauvaire, Y., Baissae, V.H., Leconte, O., Petit, P., Ribes, G., Steroid saponins from fenugreek and some of their biological properties (1996) Adv Exp Med Biol, 405, pp. 37-46; Setter, M.S., White, J.R., Campbell, R.K., Diabetes mellitus (2000) Herfindal's Textbook of Therapeutics Drug and Disease Management, pp. 377-405. , Philadelphia, Lippincott Williams & Willkins; Shirwaikar, A., Rajendran, K., Dinesh Kumar, C., Bodla, R., Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats (2004) J Ethnopharmacol, 91, pp. 171-175; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) J Ethnopharmacol, 38, pp. 151-155; Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39; Turner, M.A., (1965) Screening Methods in Pharmacology, 2nd Ed., p. 26. , New York, Academic Press; Vaidya, A.B., Terminalia arjuna in cardiovascular therapy (1994) J Assoc Physicians India, 42, pp. 281-282; Varier, P.S., (1994) Coscinium fenestratum. Indian Medicinal Plants Compendium of 500 Species, pp. 191-193. , Hyderabad, Orient Longman Ltd; Vats, V., Yadav, S.P., Grover, J.K., Effect of T. foenum graecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism (2003) J Ethnopharmacol, 85, pp. 237-242",
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pages = "707--712",
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Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats. / Shirwaikar, A.; Rajendran, K.; Punitha, I.S.R.

In: Pharmaceutical Biology, Vol. 43, No. 8, 2005, p. 707-712.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antihyperglycemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats

AU - Shirwaikar, A.

AU - Rajendran, K.

AU - Punitha, I.S.R.

N1 - Cited By :15 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: cholesterol, 57-88-5; glucose, 50-99-7, 84778-64-3; glycogen, 9005-79-2; glycosylated hemoglobin, 9062-63-9; streptozocin, 18883-66-4 References: Bainton, D., Miller, N.E., Botton, C.H., Yarnell, J.W.G., Suretman, P.M., Baker, I.A., Lewis, B., Elwood, P.C., Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men (1992) Br Heart J, 68, pp. 60-66; Berrogui, H., Ettaib, A., Herrera Gonzalez, M.D., Alvarez De Sotomayor, M., Bennani-Kabchi, N., Hmamouchi, M., Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in meriones shawi rats (2003) J Ethnopharmacol, 89, pp. 15-18; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Burcelin, R., Eddouks, M., Maury, J., Kande, J., Assan, R., Girard, J., Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin diabetic rats (1995) Diabetologia, 38, pp. 283-290; Chinnaiah, A., (2002) 1000 Siddha Medicine Notes (Tamil), 1st Ed., p. 33. , Sivakasi, Tamilnadu, India, Siva Publishers; Dwivedi, S., Agarwal, M.P., Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug in coronary artery disease (1994) J Assoc Physicians India, 42, pp. 287-289; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, 2, pp. 153-158. , Calcutta, Scientific Book Agency; Hannan, J.M.A., Rokeya, B., Faruque, O., Nahar, N., Mosihuzzaman, M., Azad Khan, A.K., Ali, L., Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status in type 2 diabetic model rats (2003) J Ethnopharmacol, 88, pp. 73-77; Harborne, J.B., (1998) Phytochemical Methods, pp. 60-66. , London, Chapman & Hall; Hostettman, K., Marston, A., (1995) Saponins, pp. 232-286. , Cambridge, Cambridge University Press; Howard, B.V., James Howard, W.M., The pathophysiology and treatment of lipid disorders in diabetes mellitus (1994) Joslin's Diabetes Mellitus, 13th Ed., p. 372. , Philadelphia, Lea & Febiger; Huang, X., Vaag, A., Hanson, M., Weng, J., Goop, L., Impaired insulin stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients in acquired rather than inherited (2000) Clin Endocrin Metabol, 85, p. 1584; Jackson, Rl., Hess, R.L., England, J.D., Hb1c values in children with over diabetes maintained in varying degree (1979) Diabetes Care, 2, pp. 391-395; Jouad, H., Lemhadri, A., Maghrani, M., Ali Zeggwah, N., Eddouks, M., Cholesterol lowering activity of the aqueous extract of Spergularia in normal and recent onset diabetic rats (2003) J Ethnopharmacol, 87, pp. 43-49; Kalavincela, T., (1998) Studies on Rural Medicine of Kanyakumari District with Special Reference to Medicinal Plants, p. 185. , M. Phil. Thesis, Manonmaniam Sundranar University, Tirunelveli, Tamilnadu, India; Koenig, R.J., Peterson, C.M., Jones, R.L., Saudek, C., Lehrman, M., Cerami, A., Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus (1976) New Engl J Med, 295, pp. 417-420; Kokate, C.K., (1994) Practical Pharmacognosy, pp. 107-113. , New Delhi, Vallabh Prakashan; Ladeji, O., Omekaran, I., Solomon, M., Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in STZ induced diabetic rats (2003) J Ethnopharmacol, 84, pp. 139-142; Lowry, O.H., Rosenburgh, N.J., Farr, A.L., Randall, R.L., Protein measurement with Folin-phenol reagent (1951) J Biol Chem, 193, pp. 265-275; Mahapatra, B., Hypoglycemic activity of Coscinium fenestratum (1997) J Res Ayu Siddha, 18, p. 89; Masiello, P., Broca, C., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, D., Novelli, M., Ribes, G., Development of a new model of type 2 diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Second report of the expert panel on detection, evaluation and treatment of high blood cholesterol in adults (1994) Circulation, 89, pp. 1329-1450; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Ind J Biol Chem, 220, p. 583; Nikkila, E.A., Kekki, M., Plasma transport kinetics in diabetes mellitus (1973) Metabolism, 22, p. 1; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Anal Biochem, 95, pp. 351-358; Ram, A., Lauria, P., Gupta, R., Kumar, P., Sharma, V.N., Hypocholesterolemic effects of Terminalia arjuna tree bark (1997) J Ethnopharmacol, 55, pp. 165-169; Sachdewa, A., Khemani, L.D., Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in STZ induced diabetes in rats (2003) J Ethnopharmacol, 89, pp. 61-66; Sauvaire, Y., Baissae, V.H., Leconte, O., Petit, P., Ribes, G., Steroid saponins from fenugreek and some of their biological properties (1996) Adv Exp Med Biol, 405, pp. 37-46; Setter, M.S., White, J.R., Campbell, R.K., Diabetes mellitus (2000) Herfindal's Textbook of Therapeutics Drug and Disease Management, pp. 377-405. , Philadelphia, Lippincott Williams & Willkins; Shirwaikar, A., Rajendran, K., Dinesh Kumar, C., Bodla, R., Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats (2004) J Ethnopharmacol, 91, pp. 171-175; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) J Ethnopharmacol, 38, pp. 151-155; Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults (1988) Arch Intern Med, 148, pp. 36-39; Turner, M.A., (1965) Screening Methods in Pharmacology, 2nd Ed., p. 26. , New York, Academic Press; Vaidya, A.B., Terminalia arjuna in cardiovascular therapy (1994) J Assoc Physicians India, 42, pp. 281-282; Varier, P.S., (1994) Coscinium fenestratum. Indian Medicinal Plants Compendium of 500 Species, pp. 191-193. , Hyderabad, Orient Longman Ltd; Vats, V., Yadav, S.P., Grover, J.K., Effect of T. foenum graecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism (2003) J Ethnopharmacol, 85, pp. 237-242

PY - 2005

Y1 - 2005

N2 - The antihyperglycemic potential of the aqueous stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the aqueous stem extract were administered to normal and experimental diabetic rats for 12 days. In extract-treated diabetic rats, an insulin-independent action with significant reduction in blood glucose, serum triglyceride, and cholesterol levels was observed. In addition, other parameters like change in body weight, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels, assessed in the extract-treated diabetic rats, were compared with diabetic control and normal animals. Significant results were observed in the above parameters thereby justifying the use of the plant in the indigenous system of medicine. © 2005 Taylor & Francis Ltd.

AB - The antihyperglycemic potential of the aqueous stem extract of Coscinium fenestratum Colebr. (Menispermaceae), a medicinal plant widely used in traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus, was evaluated in the streptozotocin-nicotinamide-induced type 2 diabetic model. Graded doses of the aqueous stem extract were administered to normal and experimental diabetic rats for 12 days. In extract-treated diabetic rats, an insulin-independent action with significant reduction in blood glucose, serum triglyceride, and cholesterol levels was observed. In addition, other parameters like change in body weight, thiobarbituric acid reactive substance levels, glycosylated hemoglobin and liver glycogen levels, assessed in the extract-treated diabetic rats, were compared with diabetic control and normal animals. Significant results were observed in the above parameters thereby justifying the use of the plant in the indigenous system of medicine. © 2005 Taylor & Francis Ltd.

U2 - 10.1080/13880200500387083

DO - 10.1080/13880200500387083

M3 - Article

VL - 43

SP - 707

EP - 712

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 8

ER -