Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata lam

A. Shirwaikar, A.P. Somashekar

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Antiinflammatory activity of the ethanol extract of the shade dried leaves of Aristolochia bracteolata lam was studied in Wistar rats by using the carrageenan induced left hind paw edema method. Significant reduction of edema volume was observed in the drug treated group when compared with the standard and untreated control. Antioxidant investigations of the ethanol extract along with its two successive fractions using nitric oxide and 1,1-diphenyl-2 picryl hydrazyl (DPPH)-induced free radical assay methods showed good free radical scavenging activity, thereby supporting its antiinflammatory properties.
Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalIndian Journal of Pharmaceutical Sciences
Volume65
Issue number1
Publication statusPublished - 2003

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Aristolochia
Free Radicals
Edema
Anti-Inflammatory Agents
Ethanol
Carrageenan
Wistar Rats
Nitric Oxide
Antioxidants
Pharmaceutical Preparations

Cite this

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title = "Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata lam",
abstract = "Antiinflammatory activity of the ethanol extract of the shade dried leaves of Aristolochia bracteolata lam was studied in Wistar rats by using the carrageenan induced left hind paw edema method. Significant reduction of edema volume was observed in the drug treated group when compared with the standard and untreated control. Antioxidant investigations of the ethanol extract along with its two successive fractions using nitric oxide and 1,1-diphenyl-2 picryl hydrazyl (DPPH)-induced free radical assay methods showed good free radical scavenging activity, thereby supporting its antiinflammatory properties.",
author = "A. Shirwaikar and A.P. Somashekar",
note = "Cited By :32 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal-576 119, India; email: annie.shirwaikar@cops.manipal.edu References: (1948) The Wealth of India: Raw Materials, 1, p. 116. , Council of Scientific and Industrial Research, New Delhi, Anonymous; Satyavati, G.V., Raina, M.K.and Sharma M., In; Medicinal Plants of India 1, Indian Council of Medical Research, New Delhi, 1976, 89; Higgs, G.A., Moncada, S., Vane, J.R., (1984) Ann. Clin. Res, 16, p. 287; Vane, J.R., (1971) Nature New Biol, 231, p. 232; Vishwanath, B.S., Fawzy, A.A., Franson, R.C., (1988) Inflammation, 12, p. 549; Kokate, C.K., (1994) Practical Pharmacognosy, p. 107. , 3 rd Edn, Vallabh Prakashan, New Delhi; Winter, C.A., Risley, G.A., Nuss, G.W., (1962) Proc. Soc. Exp. Bio. Med, 111, p. 544; Nathan, C.J., (1997) Clin. Invest, 100, p. 2417; Wong, J.M., Biliar, T.R., (1995) Adv. Pharmacol, 34, p. 155; Ialenti, A., Moncada, S., Di Rosa, M., (1993) Brit. J. Pharmacol, 110, p. 701; Ross, R., (1993) Nature, 362, p. 801",
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Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata lam. / Shirwaikar, A.; Somashekar, A.P.

In: Indian Journal of Pharmaceutical Sciences, Vol. 65, No. 1, 2003, p. 67-69.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Shirwaikar, A.

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PY - 2003

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N2 - Antiinflammatory activity of the ethanol extract of the shade dried leaves of Aristolochia bracteolata lam was studied in Wistar rats by using the carrageenan induced left hind paw edema method. Significant reduction of edema volume was observed in the drug treated group when compared with the standard and untreated control. Antioxidant investigations of the ethanol extract along with its two successive fractions using nitric oxide and 1,1-diphenyl-2 picryl hydrazyl (DPPH)-induced free radical assay methods showed good free radical scavenging activity, thereby supporting its antiinflammatory properties.

AB - Antiinflammatory activity of the ethanol extract of the shade dried leaves of Aristolochia bracteolata lam was studied in Wistar rats by using the carrageenan induced left hind paw edema method. Significant reduction of edema volume was observed in the drug treated group when compared with the standard and untreated control. Antioxidant investigations of the ethanol extract along with its two successive fractions using nitric oxide and 1,1-diphenyl-2 picryl hydrazyl (DPPH)-induced free radical assay methods showed good free radical scavenging activity, thereby supporting its antiinflammatory properties.

M3 - Article

VL - 65

SP - 67

EP - 69

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

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