Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone

M.K. Unnikrishnan, M.N.A. Rao

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more active than the sulfoxide although methionine was most active indicating that the antiinflammatory activity is not correlated with the oxidation state of sulphur. their hydroxyl radical scavenging activity was measured. Methionine was most active and sulfone was least active. Here also no correlation with antiinflammatory activity was found. © 1990 Birkhäuser Verlag.
Original languageUndefined/Unknown
Pages (from-to)110-112
Number of pages3
JournalAgents and Actions
Volume31
Issue number1-2
DOIs
Publication statusPublished - 1990

Cite this

Unnikrishnan, M.K. ; Rao, M.N.A. / Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone. In: Agents and Actions. 1990 ; Vol. 31, No. 1-2. pp. 110-112.
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Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone. / Unnikrishnan, M.K.; Rao, M.N.A.

In: Agents and Actions, Vol. 31, No. 1-2, 1990, p. 110-112.

Research output: Contribution to journalArticle

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AB - The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more active than the sulfoxide although methionine was most active indicating that the antiinflammatory activity is not correlated with the oxidation state of sulphur. their hydroxyl radical scavenging activity was measured. Methionine was most active and sulfone was least active. Here also no correlation with antiinflammatory activity was found. © 1990 Birkhäuser Verlag.

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