@article{e1a25d43d99d48e4b266ca51017091d8,
title = "Antiinflammatory and antioxidant activities of Desmodium gangeticum fractions in carrageenan-induced inflamed rats",
abstract = "Flavonoid and alkaloid fractions of Desmodium gangeticum were evaluated for antiinflammatory and antioxidant activities in carrageenan-induced inflamed rats with the aim of studying the promising fraction for inhibitory action on ferrous sulphate induced lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and total reduced glutathione in liver and spleen homogenates of inflamed rats. The results showed that the flavonoid fraction of D. gangeticum possesses potent antioxidant activity compared with the alkaloid fraction and also with respect to the standard drug indomethacin, in terms of augmentation of the liver and spleen SOD, CAT and GPX activities, concomitant with a reduction in lipid peroxidation (TBARS). In addition, the quantification of caffeic and chlorogenic acid in the flavonoid fraction has also been carried out using HPLC, which can be utilized as a marker compound in the standardization. Copyright {\textcopyright} 2007 John Wiley & Sons, Ltd.",
author = "R. Govindarajan and M. Vijayakumar and Ch.V. Rao and A. Shirwaikar and S. Kumar and A.K.S. Rawat and P. Pushpangadan",
note = "Cited By :22 Export Date: 10 November 2017 CODEN: PHYRE Correspondence Address: Govindarajan, R.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg 226 001, India; email: govind108@yahoo.com Chemicals/CAS: caffeic acid, 27323-69-9, 331-39-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; catalase, 9001-05-2; chlorogenic acid, 327-97-9; ferrous sulfate, 10028-21-4, 10124-49-9, 13463-43-9, 7720-78-7, 7782-63-0; glutathione peroxidase, 9013-66-5; indometacin, 53-86-1, 74252-25-8, 7681-54-1; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Anti-Inflammatory Agents; Antioxidants; Carrageenan, 9000-07-1; Catalase, 1.11.1.6; Desmodium gangeticum extract; Flavonoids; Glutathione Peroxidase, 1.11.1.9; Indomethacin, 53-86-1; Plant Extracts; Superoxide Dismutase, 1.15.1.1 Manufacturers: Sigma, United States References: Al-Qirim, T.M., Shahwan, M., Zaidi, K.R., Uddin, Q., Banu, N., Effect of khat, its constituents and restraint stress in free radical metabolism of rats (2002) J Ethnopharmacol, 83, pp. 245-250; Carlo, G.D., Mascolo, N., Izzo, A.A., Capasso, F., Flavonoids: Old and new aspects of a class of natural therapeutic drugs (1999) Life Sci, 65, pp. 337-353; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian Medicinal Plants, pp. 33-35. , Council of Scientific and Industrial Research: New Delhi; Cohen, G., Dembiec, D., Marcus, J., Measurement of catalase activity in tissue extracts (1970) Anal Biochem, 34, pp. 30-38; Foley, S., Navaratnam, S., David, J.M., Edward, J.L., George, T., Rice-Evans, C.A., Singlet oxygen quenching and the redox properties of hydroxycinnamic acids (1999) Free Radic Biol Med, 26, pp. 1206-1208; Ghosal, S., Bhattacharya, S.K., Desmodium alkaloids II, chemical and pharmacological evaluation of D. gangeticum (1972) Planta Med, 22, pp. 434-440; Ghosh, D., Anandkumar, A., Anti-inflammatory and analgesic activities of gangetin - A pterocarpenoid from Desmodium gangeticum (1981) Indian J Pharmacol, 15, pp. 391-402; Govindarajan, R., Rastogi, S., Vijayakumar, M., Studies on antioxidant activities of Desmodium gangeticum (2003) Biol Pharm Bull, 26, pp. 1424-1427; Govindarajan, R., Vijayakumar, M., Pushpangadan, P., Antioxidant approach to disease management and the role of Rasayana herbs of Ayurveda (2005) J Ethnopharmacol, 99, pp. 165-178; Halliwell, B., Gutteridge, J.M.C., Cross, C.E., Free radicals, antioxidants and human diseases: Where are we now? 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year = "2007",
doi = "10.1002/ptr.2199",
language = "English",
volume = "21",
pages = "975--979",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "10",
}