Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

A. Shirwaikar, S. Khan, S. Malini

Research output: Contribution to journalArticle

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Abstract

Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect. © 2003 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalJournal of Ethnopharmacology
Volume89
Issue number2-3
DOIs
Publication statusPublished - 2003

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Cissus
Ethanol
Plant Extracts
Ireland
Osteoporosis

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Shirwaikar, A. ; Khan, S. ; Malini, S. / Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. In: Journal of Ethnopharmacology. 2003 ; Vol. 89, No. 2-3. pp. 245-250.
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title = "Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat",
abstract = "Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect. {\circledC} 2003 Elsevier Ireland Ltd. All rights reserved.",
author = "A. Shirwaikar and S. Khan and S. Malini",
note = "Cited By :86 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; raloxifene, 82640-04-8, 84449-90-1; sodium chloride, 7647-14-5 References: Bahram, H.A., Lee, A., Bruce, W.H., Daxa, A., Maria, S., Peilin, G., Subhas, C.K., Dietary soybean prevents bone loss in a ovariectomized rat model of osteoporosis (1996) The Journal of Nutrition, 126, pp. 161-167; Bennet, A.E., Wahner, H.W., Riggs, B.L., Soya - A dietary source of the non steroidal oestrogen equal in man and animals (1984) Journal of Endocrinology, 102, pp. 49-56; Burtis, C.A., Ashwood, E.R., (1986) Tietz Text Book of Clinical Biochemisry, 2nd ed., 833, pp. 1890-1891. , Saunders, London; Canalis, H., McCarthy, T., Centrella, M., Growth factors and the regulation on bone remodeling (1998) Journal of Clinical Investigation, 81, pp. 277-281; Genant, H.K., Bay Link, D.J., Gallagher, J.C., Estrogens in the prevention of osteoporosis in post menopausal women (1998) American Journal of Obsteterics and Gynaecology, 161, pp. 1842-1846; Holford-Walker, A., (1981) Herbal Remedies and Drugs Used by the Maasai; Political Records, , Miscellaneous-Narole district. File No. DC/NRK/3/1. Kenya National Archives, Nairobi; Jayaweera, D.M.A., (1980) Medicinal Plants Used in Ceylon (Parts 01-05), , The National Science Council of Srilanka; Khan, S.S., Singh, M.P., Chaghtai, S.A., Ethnomedicobotany of Cissus quadrangularis Linn (1991) Oriental Journal of Chemistry, 7, pp. 170-172; Kumbhojkar, M.S., Kulkarni, D.K., Upadhye, A.S., Ethnobotany of Cissus quadrangularis L. from India (1991) Ethnobotany, 3, pp. 21-25; Marcus, R., Introduction: Organizational and Functional Aspects of Skeletal Health (1994) Osteoporosis, , Kanis, J.A. (Ed.). Blackwell Science, Ltd., Oxford, England; Meryl, S.L., (1997) Metabolic Bone Diseases in Text Book of Rheumatology, 5th ed., pp. 1563-1572. , Harris, K., Sludge, R. (Eds.). Saunders, London; Nadkarni, A.K., (1954) Indian Materia Medica, 13th ed., pp. 284-285. , Dhootapapeshwar Prakashan, Ltd., Bombay; Ogey, A., Bayraktar, F., Sevin, G., A comparative study of Raloxifen and estrogen on bone strength and cholesterol levels in ovariectomized rats (2001) Endocrine Abstracts, 3, p. 10; Peng, Z., Tuukkanen, J., Zhang, H., The mechanical strength of bone in different rat models of experimental osteoporosis (1994) Bone, 15, pp. 523-532; Prasad, G.C., Udupa, K.N., Effect of Cissus quadrangularis on the healing of cortisone treated fracture (1963) Indian Journal of Medical Research, 51, p. 667; Prasad, G.C., Udupa, K.N., Pathways and site of action of a phytogenic steroid from Cissus quadrangularis (1972) Journal of Research in Indian Medicine, 4, p. 132; Robert, L.J., Stavros, C.M., The Cellular and Biomechanical Basis of Bone Remodeling (1994) Osteoporosis, pp. 22-23. , Marcus R. (Ed.). Blackwell Publications, London; Sen, S.P., Studies on the active constituents of Cissus quadrangularis wall (1966) Current Science, 35, p. 317; Sivarajan, V.V., Balachandran, I., (1994) Ayurvedic Drugs and Their Plant Sources, p. 496. , Oxford and India Book House Publishing Co. Pvt. Ltd., New Delhi; Udupa, K.N., Prasad, G., 10 Further studies on the effect of Cissus quadrangularis in accelerating fracture healing (1964) Indian Journal of Medical Research, 52, p. 26; Udupa, K.N., Prasad, G., Biochemical and Ca45 studies on the effect of Cissus quadrangularis in fracture healing (1964) Indian Journal of Medical Research, 52, pp. 480-487; Udupa, K.N., Prasad, G.C., Sen, S.P., The effect of phytogenic steroid in the accleration of fracture repair (1965) Life Science, 4, p. 317; Udupa, K.N., Chaturvedi, G.N., Tripathi, S.N., (1970) Advances in Research in Indian Medicine, 12, pp. 165-196. , Banaras Hindu University, Varanasi; Varley, H., (1980) Practical Biochemistry, 1, p. 913. , William Heinemann Medical Books Ltd, London; Yoganarsimhan, S.N., (2000) Medicinal Plants of India, 2, pp. 136-137. , Cyber Media Bangalore",
year = "2003",
doi = "10.1016/j.jep.2003.08.004",
language = "English",
volume = "89",
pages = "245--250",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. / Shirwaikar, A.; Khan, S.; Malini, S.

In: Journal of Ethnopharmacology, Vol. 89, No. 2-3, 2003, p. 245-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

AU - Shirwaikar, A.

AU - Khan, S.

AU - Malini, S.

N1 - Cited By :86 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; raloxifene, 82640-04-8, 84449-90-1; sodium chloride, 7647-14-5 References: Bahram, H.A., Lee, A., Bruce, W.H., Daxa, A., Maria, S., Peilin, G., Subhas, C.K., Dietary soybean prevents bone loss in a ovariectomized rat model of osteoporosis (1996) The Journal of Nutrition, 126, pp. 161-167; Bennet, A.E., Wahner, H.W., Riggs, B.L., Soya - A dietary source of the non steroidal oestrogen equal in man and animals (1984) Journal of Endocrinology, 102, pp. 49-56; Burtis, C.A., Ashwood, E.R., (1986) Tietz Text Book of Clinical Biochemisry, 2nd ed., 833, pp. 1890-1891. , Saunders, London; Canalis, H., McCarthy, T., Centrella, M., Growth factors and the regulation on bone remodeling (1998) Journal of Clinical Investigation, 81, pp. 277-281; Genant, H.K., Bay Link, D.J., Gallagher, J.C., Estrogens in the prevention of osteoporosis in post menopausal women (1998) American Journal of Obsteterics and Gynaecology, 161, pp. 1842-1846; Holford-Walker, A., (1981) Herbal Remedies and Drugs Used by the Maasai; Political Records, , Miscellaneous-Narole district. File No. DC/NRK/3/1. Kenya National Archives, Nairobi; Jayaweera, D.M.A., (1980) Medicinal Plants Used in Ceylon (Parts 01-05), , The National Science Council of Srilanka; Khan, S.S., Singh, M.P., Chaghtai, S.A., Ethnomedicobotany of Cissus quadrangularis Linn (1991) Oriental Journal of Chemistry, 7, pp. 170-172; Kumbhojkar, M.S., Kulkarni, D.K., Upadhye, A.S., Ethnobotany of Cissus quadrangularis L. from India (1991) Ethnobotany, 3, pp. 21-25; Marcus, R., Introduction: Organizational and Functional Aspects of Skeletal Health (1994) Osteoporosis, , Kanis, J.A. (Ed.). Blackwell Science, Ltd., Oxford, England; Meryl, S.L., (1997) Metabolic Bone Diseases in Text Book of Rheumatology, 5th ed., pp. 1563-1572. , Harris, K., Sludge, R. (Eds.). Saunders, London; Nadkarni, A.K., (1954) Indian Materia Medica, 13th ed., pp. 284-285. , Dhootapapeshwar Prakashan, Ltd., Bombay; Ogey, A., Bayraktar, F., Sevin, G., A comparative study of Raloxifen and estrogen on bone strength and cholesterol levels in ovariectomized rats (2001) Endocrine Abstracts, 3, p. 10; Peng, Z., Tuukkanen, J., Zhang, H., The mechanical strength of bone in different rat models of experimental osteoporosis (1994) Bone, 15, pp. 523-532; Prasad, G.C., Udupa, K.N., Effect of Cissus quadrangularis on the healing of cortisone treated fracture (1963) Indian Journal of Medical Research, 51, p. 667; Prasad, G.C., Udupa, K.N., Pathways and site of action of a phytogenic steroid from Cissus quadrangularis (1972) Journal of Research in Indian Medicine, 4, p. 132; Robert, L.J., Stavros, C.M., The Cellular and Biomechanical Basis of Bone Remodeling (1994) Osteoporosis, pp. 22-23. , Marcus R. (Ed.). Blackwell Publications, London; Sen, S.P., Studies on the active constituents of Cissus quadrangularis wall (1966) Current Science, 35, p. 317; Sivarajan, V.V., Balachandran, I., (1994) Ayurvedic Drugs and Their Plant Sources, p. 496. , Oxford and India Book House Publishing Co. Pvt. Ltd., New Delhi; Udupa, K.N., Prasad, G., 10 Further studies on the effect of Cissus quadrangularis in accelerating fracture healing (1964) Indian Journal of Medical Research, 52, p. 26; Udupa, K.N., Prasad, G., Biochemical and Ca45 studies on the effect of Cissus quadrangularis in fracture healing (1964) Indian Journal of Medical Research, 52, pp. 480-487; Udupa, K.N., Prasad, G.C., Sen, S.P., The effect of phytogenic steroid in the accleration of fracture repair (1965) Life Science, 4, p. 317; Udupa, K.N., Chaturvedi, G.N., Tripathi, S.N., (1970) Advances in Research in Indian Medicine, 12, pp. 165-196. , Banaras Hindu University, Varanasi; Varley, H., (1980) Practical Biochemistry, 1, p. 913. , William Heinemann Medical Books Ltd, London; Yoganarsimhan, S.N., (2000) Medicinal Plants of India, 2, pp. 136-137. , Cyber Media Bangalore

PY - 2003

Y1 - 2003

N2 - Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect. © 2003 Elsevier Ireland Ltd. All rights reserved.

AB - Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect. © 2003 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.jep.2003.08.004

DO - 10.1016/j.jep.2003.08.004

M3 - Article

VL - 89

SP - 245

EP - 250

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 2-3

ER -