Antioxidant activity of Caesalpinia sappan heartwood

Shrishailappa Badami, Sudheer Moorkoth, Sujay Rammanoharsingh Rai, Elango Kannan, Suresh Bhojraj

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Antioxidant activity of Caesalpinia sappan heartwood was studied both by in vitro and in vivo models. The ethyl acetate, methanol and water extracts exhibited strong antioxidant activity as evidenced by the low IC50 values in both 1,1-diphenyl-2-picryl hydrazyl (DPPH) and nitric oxide methods. The values were found to be less or comparable to those of ascorbic acid and rutin, the standards used. Administration of the successive methanol and water extracts at 50 and 100 mg/kg body weight given for four days prior to carbon tetrachloride (CCl4) treatment caused a significant increase in the level of superoxide dismutase (SOD) and catalase and a significant decrease in the level of thiobarbituric acid reactive substances (TBARS), when compared to CCl4 treated control in both liver and kidney. These changes observed at 100 mg/kg body weight treatment were comparable to those observed for standard vitamin E at 50 mg/kg treatment. The results support significant antioxidant nature of Caesalpinia sappan heartwood extracts.

Original languageEnglish
Pages (from-to)1534-1537
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number11
DOIs
Publication statusPublished - 01-11-2003

Fingerprint

Caesalpinia
Antioxidants
Methanol
Body Weight
Rutin
Thiobarbituric Acid Reactive Substances
Water
Carbon Tetrachloride
Vitamin E
Catalase
Ascorbic Acid
Inhibitory Concentration 50
Superoxide Dismutase
Nitric Oxide
Kidney
Liver

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Badami, Shrishailappa ; Moorkoth, Sudheer ; Rai, Sujay Rammanoharsingh ; Kannan, Elango ; Bhojraj, Suresh. / Antioxidant activity of Caesalpinia sappan heartwood. In: Biological and Pharmaceutical Bulletin. 2003 ; Vol. 26, No. 11. pp. 1534-1537.
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Antioxidant activity of Caesalpinia sappan heartwood. / Badami, Shrishailappa; Moorkoth, Sudheer; Rai, Sujay Rammanoharsingh; Kannan, Elango; Bhojraj, Suresh.

In: Biological and Pharmaceutical Bulletin, Vol. 26, No. 11, 01.11.2003, p. 1534-1537.

Research output: Contribution to journalArticle

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