Antioxidant activity of Hypericum hookerianum Wight and Arn.

H. Raghu Chandrashekhar, P. Venkatesh, S. Ponnusankar, P. Vijayan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and liver homogenate were analysed. CCl(4) treatment caused a significant increase in the level of CAT and SOD and a significant decrease in the level of LPO in a dose-dependent manner when compared to CCl(4) treated control. The results indicate the strong antioxidant nature of H. hookerianum leaf extract.
Original languageEnglish
Pages (from-to)1240-1251
Number of pages12
JournalNatural Product Research
Volume23
Issue number13
Publication statusPublished - 2009

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Hypericum
Antioxidants
antioxidant activity
antioxidants
leaf extracts
catalase
superoxide dismutase
extracts
lipid peroxidation
Catalase
flowers
Lipid Peroxidation
Superoxide Dismutase
flavanols
Lipids
phenol
aerial parts
animal models
Phenol
Liver

Cite this

Raghu Chandrashekhar, H., Venkatesh, P., Ponnusankar, S., & Vijayan, P. (2009). Antioxidant activity of Hypericum hookerianum Wight and Arn. Natural Product Research, 23(13), 1240-1251.
Raghu Chandrashekhar, H. ; Venkatesh, P. ; Ponnusankar, S. ; Vijayan, P. / Antioxidant activity of Hypericum hookerianum Wight and Arn. In: Natural Product Research. 2009 ; Vol. 23, No. 13. pp. 1240-1251.
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abstract = "Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and liver homogenate were analysed. CCl(4) treatment caused a significant increase in the level of CAT and SOD and a significant decrease in the level of LPO in a dose-dependent manner when compared to CCl(4) treated control. The results indicate the strong antioxidant nature of H. hookerianum leaf extract.",
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Raghu Chandrashekhar, H, Venkatesh, P, Ponnusankar, S & Vijayan, P 2009, 'Antioxidant activity of Hypericum hookerianum Wight and Arn.', Natural Product Research, vol. 23, no. 13, pp. 1240-1251.

Antioxidant activity of Hypericum hookerianum Wight and Arn. / Raghu Chandrashekhar, H.; Venkatesh, P.; Ponnusankar, S.; Vijayan, P.

In: Natural Product Research, Vol. 23, No. 13, 2009, p. 1240-1251.

Research output: Contribution to journalArticle

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AB - Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and liver homogenate were analysed. CCl(4) treatment caused a significant increase in the level of CAT and SOD and a significant decrease in the level of LPO in a dose-dependent manner when compared to CCl(4) treated control. The results indicate the strong antioxidant nature of H. hookerianum leaf extract.

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