Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats

S. Vijaya Kumar, D.B. Sanghai, C. Mallikarjuna Rao, C.S. Shreedhara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Melia azedarach Linn, a deciduous tree belonging to Family Meliaceae, has been used traditionally for variety of ailments. Antioxidant and antihyperlipidemic activities of the extracts of leaves of Melia azedarach were studied by in vitro antioxidant assays and in vivo effects by Triton-WR 139 induced hyperlipidaemic model and high fat diet induced hyperlipidaemia model in Wistar albino rats. The phenolic and flavonoid content was also estimated. In Triton induced hyperlipidaemic model and also in high fat induced hyperlipidaemic model, aqueous and methanolic extracts has shown significant lipid lowering activity. In antioxidant activity study, ethyl acetate extract showed better IC50 values in the DPPH and ABTS model, whereas, in o-phenanthroline assay, chloroform extract has shown better IC50 value. Phenolic content in aqueous extract was found to be more, while flavonoid content in ethyl acetate extract.

Original languageEnglish
Pages (from-to)1195-1199
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume6
Issue number11
Publication statusPublished - 2013

Fingerprint

Melia azedarach
Hypolipidemic Agents
Antioxidants
Flavonoids
Inhibitory Concentration 50
Meliaceae
High Fat Diet
Chloroform
Hyperlipidemias
Wistar Rats
Fats
Lipids
ethyl acetate

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

Cite this

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Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats. / Vijaya Kumar, S.; Sanghai, D.B.; Mallikarjuna Rao, C.; Shreedhara, C.S.

In: Research Journal of Pharmacy and Technology, Vol. 6, No. 11, 2013, p. 1195-1199.

Research output: Contribution to journalArticle

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