|Number of pages||7|
|Journal||Indian Journal of Experimental Biology|
|Publication status||Published - 2006|
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Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation. / Shirwaikar, A.; Aswatha Ram, H.N.; Mohapatra, P.In: Indian Journal of Experimental Biology, Vol. 44, No. 6, 2006, p. 474-480.
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TY - JOUR
T1 - Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation
AU - Shirwaikar, A.
AU - Aswatha Ram, H.N.
AU - Mohapatra, P.
N1 - Cited By :15 Export Date: 10 November 2017 CODEN: IJEBA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India; email: firstname.lastname@example.org Chemicals/CAS: alcohol, 64-17-5; ibuprofen, 15687-27-1; nitric oxide, 10102-43-9; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid, 28752-68-3; Alcohols; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Ethanol, 64-17-5; Ibuprofen, 15687-27-1; Nitric Oxide, 10102-43-9; Plant Extracts; Sulfonic Acids References: (1951) Bhaisjya Ratnawali, p. 242. , Kaviraj Sri Ambidatasastri Ayurvedacharya, Churbabha sanskurrata Saasthan, publisher of Indian Sanskrit Literature and Distributors, Varanasi; (1981) Formulary of Ayurvedic Medicine, 2nd Edition, p. 54. , The Indian Medical Practitioner's Co-operative Pharmacy and Stores Ltd., ADYAR, Madras; Satyanarayana, S., Kumar, P.P., Visweswaram, D., Antiulcer activity of Agnitundirasa and its comparison with cimetidine in shay rat (1989) Ancient Sci Life, 3-4, p. 207; Gutteridge, J.M., Lipid peroxidation and antioxidants as biomarkers of tissue damage (1995) Clin Chem, 41, p. 1819; (1978) Ayurvedic Formulary of India, Part-I, 1st Edition, p. 95. , Government of India, Ministry of Health and Family Planning, Department of Health, New Delhi; Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arrredondo, F., Dajas, F., Tripathi, P.C., Mukherjee, B., Screening of antioxidant activity of three Indian medicinal plants traditionally used for the management of neurodegenerative disease (2003) J Ethnopharmacol, 84, p. 132; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thio barbituric acid reaction (1979) Anal Biochem, 95, p. 351; Prashanth Kumar, V., Shashidhara, S., Kumar, M.M., Sridhara, B.Y., Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity (2000) J Pharm Pharmacol, 52, p. 891; Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C., Antioxidant activity applying an improved ABTS radical cation assay (1999) Free Rad Biol Med, 26, p. 1231; Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Res, 46, p. 169; Sreejayan, N., Rao, M.N.A., Nitric Oxide scavenging by curcuminoids (1997) J Pharm Pharmacol, 49, p. 105; Annie, S., Somashekar, A.P., Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata Lam (2003) Indian J Pharm Sci, 65, p. 68; Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R., Analysis of nitrate and 15N in biological fluids (1982) Anal Biochem, 126, p. 131; Marcocci, L., Maguire, J.J., Droy-Lefaix, M.T., Packer, L., The nitric oxide scavenging property of Ginko biloba extract EGB 761 (1994) Biochem Biophys Res Commun, 201, p. 748; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, p. 153. , Scientific Book agency, Calcutta; Turner, M.A., (1965) Screening Method in Pharmacology, p. 26. , Academic Press, New York; Rao, C.M., Ramesh, K.V., Bairy, K.L., Kulkarni, D.R., Zinc complexes of NSAID's abolish gastric ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 64; Mallikarjuna Rao, C., Ramesh, K.V., Bairy, K.L., Kulkarni, D., Zinc complexes of NSAID's abolish gastric IC ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 67; Morimoto, Y., Shimohara, K., Oshima, S., Sukamato, T., Effect of the new antiulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine (1991) Japanese Pharmacol, 57, p. 495; Drury, R.A.B., Wellington, E.A., (1976) Carleton's Histological Technique, 4th Edition, p. 85. , Oxford University Press, London; Andrew, H., Soll, M.D., Pathogenesis of peptic ulcer and implication of therapy (1990) The New England J Med, 322, p. 909; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogensis of peptic ulcer disease and current trends in therapy (1997) Indian J Physiol Pharmacol, 41, p. 3; Soll, A.H., Pathogensis of peptic ulcer and implications for therapy (1990) The New England J Med, 322, p. 909; Bandyopadhyay, U., Das, D., Bandyopadyay, D., Bhattacharjee, M., Banerjee, R.K., Role of reactive oxygen species in mercaptomethylimidazole - Induced gastric acid secretion and stress - Induced gastric ulceration (1999) Curr Sci, 76, p. 55; Naito, Y., Yoshikawa, T., Matusyama, K., Yagi, N., Aral, M., Nakamura, S., Yoshida, N., Konda, M., Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats (1995) Clinic Gastroenterol, 21, pp. S82; Vander Laan, L., Kapitein, P.J., Oyen, W.J., Verhofstad, A.A., Hendriks, T., Goris, R.J., A novel animal model to evaluate oxygen derived free radical damage in soft tissue (1997) Free Radical Research, 26, p. 363; Oates, P.J., Hakkinen, J.P., Studies on the mechanism ethanol-induced gastric damage in rats (1988) Gastroenterology, 94, p. 10; Mizui, T., Sato, H., Hirose, F., Doteuchi, M., Effect of antiperoxidative drugs on gastric damage induced by ethanol in irats (1987) Life Sci, 41, p. 755; Peskar, B.M., Lange, K., Hoppe, U., Peskar, B.A., Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa (1986) Prostagalndins, 31, p. 283; Shirwaikar, A., Bhilegaonkar, P.M., Malini, S., Sharath Kumar, J., The gastroprotective activity of the ethanol extract of Ageratum conyzoides (2003) J Ethnopharmacol, 86, p. 117; 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Health Perspect, 67, p. 135; Murakami, A., Tanaka, T., Lee, J.Y., Surh, Y.J., Kim, H.W., Kawabata, K., Nakamura, Y., Onigashi, H., Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice (2004) Int J Cancer, 110, p. 481; Saleem, M., Alam, A., Sultana, S., Asafoetida inhibits early events of carcinogenesis: A chemopreventive study (2001) Life Sci, 68, p. 1931; Agarwal, A.K., Rao, C.V., Sairam, K., Joshi, V.K., Goel, R.K., Effect of Piper longum, Zingiber officinalis and Ferula species on gastric ulceration and secretion in rats (2000) Indian J Exp Biol, 38, p. 994; Pihan, G., Majzoubi, D., Haudenschild, C., Trier, J.S., Szabo, S., Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,6 dimethyl prostaglandin E2 or sodium thiosulfate (1986) Gastroenterology, 91, p. 1415
PY - 2006
Y1 - 2006
N2 - The aqueous extract of Hingwashtak churna was evaluated for gastroprotection in rats using the ibuprofen and ethanol induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the aqueous extract (750 mg/kg) significantly protected against gastric lesions by 84.96% and 91.12% as compared to ranititidine (95.54 and 95.2%) in the ibuprofen and alcohol induced ulcer models respectively. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity which was evaluated by using different antioxidant models of screening.
AB - The aqueous extract of Hingwashtak churna was evaluated for gastroprotection in rats using the ibuprofen and ethanol induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the aqueous extract (750 mg/kg) significantly protected against gastric lesions by 84.96% and 91.12% as compared to ranititidine (95.54 and 95.2%) in the ibuprofen and alcohol induced ulcer models respectively. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity which was evaluated by using different antioxidant models of screening.
M3 - Article
VL - 44
SP - 474
EP - 480
JO - Journal of scientific & industrial research. C. Biological sciences
JF - Journal of scientific & industrial research. C. Biological sciences
SN - 0019-5189
IS - 6