Antioxidant and radiation antagonistic effect of Saraca indica

Bola Sadashiva Satish Rao, Nageshwar Rao, P. R. Archana, P. Gayathri, Prerana Shetty

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study was undertaken to investigate the radiation mitigating effect of hydro-alcoholic extract of Saraca indica (SIE) against mice exposed to whole body gamma radiation. Free radical scavenging ability by SIE was demonstrated using hydroxyl, superoxide anion, ABTS and DPPH radicals generated in vitro. A significant increase in the animal survival (dose reduction factor 1.39), inhibition in the decline of hematological parameters as well as increased number of spleen colony-forming units was observed when SIE was administered prior to radiation. SIE pretreatment increased the levels of glutathione, glutathione S- trans-ferase, catalase and lowered lipid peroxidation. Our findings for the first time demonstrate the protective potential of SIE against radiation induced syndromes with an optimal dose of 400 mg/kg b.wt. The radiation mitigating effect may be attributed to the mechanisms such as free radical scavenging, elevation in antioxidant status, and reduction in lipid peroxidation.

Original languageEnglish
Pages (from-to)69-79
Number of pages11
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume29
Issue number1
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medicine(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

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