Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives

S. A. Manohara Reddy, Jayesh Mudgal, Punit Bansal, S. G. Vasanthraju, K. K. Srinivasan, C. Mallikarjuna Rao, N. Gopalan Kutty

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti-hyperlipidaemic activities. Compounds with thioxo- and oxoimidazole ring (1) and (2) have shown potent antioxidant activity with IC50 values 0.23 ± 0.09 and 0.41 ± 0.01 mM comparable with standard ascorbic acid. Compound (3) with a quinoxaline ring showed maximum inhibition of BSA denaturation at 1 mM concentration and comparable with standard diclofenac. Incorporation of electron withdrawing substitutions like chloro- and nitro-groups in the quinoxaline ring has resulted in an increase anti-inflammatory activity. Test compounds (3), (3a) and (3c) showed modest inhibition of DPP-IV in vitro. However, the unsubstituted quinoxaline (3) and substituted quinoxalines (3b and 3c) reduced plasma glucose levels indicating the presence of hypoglycemic activity.

Original languageEnglish
Pages (from-to)384-392
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number1
DOIs
Publication statusPublished - 01-01-2011

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Quinoxalines
Anti-Inflammatory Agents
Antioxidants
Derivatives
Ricinoleic Acids
Denaturation
Diclofenac
Hypoglycemic Agents
Ascorbic Acid
Inhibitory Concentration 50
Substitution reactions
Electrons
Plasmas
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti-hyperlipidaemic activities. Compounds with thioxo- and oxoimidazole ring (1) and (2) have shown potent antioxidant activity with IC50 values 0.23 ± 0.09 and 0.41 ± 0.01 mM comparable with standard ascorbic acid. Compound (3) with a quinoxaline ring showed maximum inhibition of BSA denaturation at 1 mM concentration and comparable with standard diclofenac. Incorporation of electron withdrawing substitutions like chloro- and nitro-groups in the quinoxaline ring has resulted in an increase anti-inflammatory activity. Test compounds (3), (3a) and (3c) showed modest inhibition of DPP-IV in vitro. However, the unsubstituted quinoxaline (3) and substituted quinoxalines (3b and 3c) reduced plasma glucose levels indicating the presence of hypoglycemic activity.",
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Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives. / Manohara Reddy, S. A.; Mudgal, Jayesh; Bansal, Punit; Vasanthraju, S. G.; Srinivasan, K. K.; Rao, C. Mallikarjuna; Gopalan Kutty, N.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 1, 01.01.2011, p. 384-392.

Research output: Contribution to journalArticle

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AU - Bansal, Punit

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AU - Srinivasan, K. K.

AU - Rao, C. Mallikarjuna

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