Antioxidant potential of Anogeissus latifolia

R. Govindarajan, M. Vijayakumar, C.V. Rao, A. Shirwaikar, A.K.S. Rawat, S. Mehrotra, P. Pushpangadan

Research output: Contribution to journalArticle

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Abstract

Anogeissus latifolia is widely used in the Indian indigenous system of medicine and is reported to contain leucocyanidins and tannoid principles like ellagic acid and its derivatives. In view of its wide use and its chemical composition, this study was aimed at examining the antioxidant activity of the extract of A. latifolia. The extract was studied for total antioxidant capacity, hydrogen-donating ability, nitric oxide, superoxide scavenging activity, hydrogen peroxide decomposition activity along with lipid peroxidation. Integral antioxidative capacity was determined by chemiluminescence assay. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat liver homogenate. The results indicate that A. latifolia extract has potent antioxidant activity. Also to ascertain the possible reason for the potent activity, percentage of gallic acid was estimated and was found to be 0.95%, which could be one of the reasons for potent antioxidant activity exhibited by the plant. © 2004 Pharmaceutical Society of Japan.
Original languageEnglish
Pages (from-to)1266-1269
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number8
DOIs
Publication statusPublished - 2004

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Antioxidants
Lipid Peroxidation
Pharmaceutical Societies
Ellagic Acid
Gallic Acid
Thiobarbituric Acid Reactive Substances
Traditional Medicine
Systems Analysis
Luminescence
Superoxides
Hydrogen Peroxide
Hydrogen
Japan
Nitric Oxide
Liver

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Govindarajan, R., Vijayakumar, M., Rao, C. V., Shirwaikar, A., Rawat, A. K. S., Mehrotra, S., & Pushpangadan, P. (2004). Antioxidant potential of Anogeissus latifolia. Biological and Pharmaceutical Bulletin, 27(8), 1266-1269. https://doi.org/10.1248/bpb.27.1266
Govindarajan, R. ; Vijayakumar, M. ; Rao, C.V. ; Shirwaikar, A. ; Rawat, A.K.S. ; Mehrotra, S. ; Pushpangadan, P. / Antioxidant potential of Anogeissus latifolia. In: Biological and Pharmaceutical Bulletin. 2004 ; Vol. 27, No. 8. pp. 1266-1269.
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note = "Cited By :61 Export Date: 10 November 2017 CODEN: BPBLE Correspondence Address: Mehrotra, S.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-226 001, India; email: pharmacognosy1@rediffmail.com Chemicals/CAS: gallic acid, 149-91-7; hydrogen peroxide, 7722-84-1; nitric oxide, 10102-43-9; superoxide, 11062-77-4; Antioxidants References: Tiwari, A.K., (2001) Current Science, 81, pp. 1179-1187; Schulz, J.B., Lindnau, J., Seyfriend, J., Dichgans, J., (2000) Eur. J. Biochem., 267, pp. 4904-4911; Dringen, R., (2000) Eur. J. Biochem., 267, p. 4903; Geesin, J.C., Gordon, J.S., Berg, R.A., (1990) Arch. Biochem. Biophys., 278, pp. 350-355; Theismania, K.C., Kuttan, R., (1996) Indian J. Physiol. Pharmacol., 40, pp. 363-366; Reddy, K.K., Rajadurai, S., Nayudamma, Y., (1965) Indian J. Chem., 3, pp. 308-310; Deshpande, V.H., Patil, A.D., Rama Rao, A.V., Venkatraman, K., (1976) Indian J. Chem., 14 B, pp. 641-643; Roy, G.P., Chaturvedi, G.P., (1986) Folklore, 27, pp. 95-100; Mishra, R., Billore, K.V., (1983) Nagarjun, 26, pp. 229-231; Jain, S.K., Tarafder, C.R., (1970) Econ. Bot., 24, pp. 241-278; Apparanantham, T., Chelladurai, V., (1986) Anc. Sci. Life, 5, pp. 182-185; Balla, N.P., Sahu, T.R., Mishra, G.P., (1982) J. Econ. Tax. Bot., 3, pp. 23-32; Ramachandran, V.S., Nair, N.C., (1981) J. Econ. Tax. Bot., 2, pp. 183-190; Sreejayan, N., Rao, M.N.A., (1996) Drug Research, 46, pp. 169-171; Preito, P., Pineda, M., Aguilar, M., (1999) Anal. Biochem., 269, pp. 337-341; Govindarajan, R., Vijayakumar, M., Rawat, A.K.S., Mehrotra, S., (2003) Indian J. Exp. Biol., 41, pp. 875-879; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P., (2003) Biol. Pharm. Bull., 26, pp. 1424-1427; Henry, L.E.A., Halliwell, B., Hall, D.O., (1976) FEBS Lett., 66, pp. 303-306; Okhawa, H., Ohishi, N., Yagi, K., (1979) Anal. Biochem., 95, pp. 351-355; Tripathi, Y.B., Sharma, M., (1998) Indian J. Biochem. Biophys., 35, pp. 313-316; Valentao, P., Fernndes, E., Canvalho, E., Andrade, P.B., Seabra, R.M., Bastos, M.L., (2002) Biol. Pharm. Bull., 25, pp. 1324-1327; Miller, M.J., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J.L., Clark, D.A., (1992) J. Pharmacol. Exp. Therapeutics, 264, pp. 11-16; Halliwell, B., Gutteridge, J.M.C., (1993) Free Radicals in Biology and Medicine, pp. 419-422. , Clarendon, Oxford",
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Govindarajan, R, Vijayakumar, M, Rao, CV, Shirwaikar, A, Rawat, AKS, Mehrotra, S & Pushpangadan, P 2004, 'Antioxidant potential of Anogeissus latifolia', Biological and Pharmaceutical Bulletin, vol. 27, no. 8, pp. 1266-1269. https://doi.org/10.1248/bpb.27.1266

Antioxidant potential of Anogeissus latifolia. / Govindarajan, R.; Vijayakumar, M.; Rao, C.V.; Shirwaikar, A.; Rawat, A.K.S.; Mehrotra, S.; Pushpangadan, P.

In: Biological and Pharmaceutical Bulletin, Vol. 27, No. 8, 2004, p. 1266-1269.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antioxidant potential of Anogeissus latifolia

AU - Govindarajan, R.

AU - Vijayakumar, M.

AU - Rao, C.V.

AU - Shirwaikar, A.

AU - Rawat, A.K.S.

AU - Mehrotra, S.

AU - Pushpangadan, P.

N1 - Cited By :61 Export Date: 10 November 2017 CODEN: BPBLE Correspondence Address: Mehrotra, S.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-226 001, India; email: pharmacognosy1@rediffmail.com Chemicals/CAS: gallic acid, 149-91-7; hydrogen peroxide, 7722-84-1; nitric oxide, 10102-43-9; superoxide, 11062-77-4; Antioxidants References: Tiwari, A.K., (2001) Current Science, 81, pp. 1179-1187; Schulz, J.B., Lindnau, J., Seyfriend, J., Dichgans, J., (2000) Eur. J. Biochem., 267, pp. 4904-4911; Dringen, R., (2000) Eur. J. Biochem., 267, p. 4903; Geesin, J.C., Gordon, J.S., Berg, R.A., (1990) Arch. Biochem. Biophys., 278, pp. 350-355; Theismania, K.C., Kuttan, R., (1996) Indian J. Physiol. Pharmacol., 40, pp. 363-366; Reddy, K.K., Rajadurai, S., Nayudamma, Y., (1965) Indian J. Chem., 3, pp. 308-310; Deshpande, V.H., Patil, A.D., Rama Rao, A.V., Venkatraman, K., (1976) Indian J. Chem., 14 B, pp. 641-643; Roy, G.P., Chaturvedi, G.P., (1986) Folklore, 27, pp. 95-100; Mishra, R., Billore, K.V., (1983) Nagarjun, 26, pp. 229-231; Jain, S.K., Tarafder, C.R., (1970) Econ. Bot., 24, pp. 241-278; Apparanantham, T., Chelladurai, V., (1986) Anc. Sci. Life, 5, pp. 182-185; Balla, N.P., Sahu, T.R., Mishra, G.P., (1982) J. Econ. Tax. Bot., 3, pp. 23-32; Ramachandran, V.S., Nair, N.C., (1981) J. Econ. Tax. Bot., 2, pp. 183-190; Sreejayan, N., Rao, M.N.A., (1996) Drug Research, 46, pp. 169-171; Preito, P., Pineda, M., Aguilar, M., (1999) Anal. Biochem., 269, pp. 337-341; Govindarajan, R., Vijayakumar, M., Rawat, A.K.S., Mehrotra, S., (2003) Indian J. Exp. Biol., 41, pp. 875-879; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P., (2003) Biol. Pharm. Bull., 26, pp. 1424-1427; Henry, L.E.A., Halliwell, B., Hall, D.O., (1976) FEBS Lett., 66, pp. 303-306; Okhawa, H., Ohishi, N., Yagi, K., (1979) Anal. Biochem., 95, pp. 351-355; Tripathi, Y.B., Sharma, M., (1998) Indian J. Biochem. Biophys., 35, pp. 313-316; Valentao, P., Fernndes, E., Canvalho, E., Andrade, P.B., Seabra, R.M., Bastos, M.L., (2002) Biol. Pharm. Bull., 25, pp. 1324-1327; Miller, M.J., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J.L., Clark, D.A., (1992) J. Pharmacol. Exp. Therapeutics, 264, pp. 11-16; Halliwell, B., Gutteridge, J.M.C., (1993) Free Radicals in Biology and Medicine, pp. 419-422. , Clarendon, Oxford

PY - 2004

Y1 - 2004

N2 - Anogeissus latifolia is widely used in the Indian indigenous system of medicine and is reported to contain leucocyanidins and tannoid principles like ellagic acid and its derivatives. In view of its wide use and its chemical composition, this study was aimed at examining the antioxidant activity of the extract of A. latifolia. The extract was studied for total antioxidant capacity, hydrogen-donating ability, nitric oxide, superoxide scavenging activity, hydrogen peroxide decomposition activity along with lipid peroxidation. Integral antioxidative capacity was determined by chemiluminescence assay. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat liver homogenate. The results indicate that A. latifolia extract has potent antioxidant activity. Also to ascertain the possible reason for the potent activity, percentage of gallic acid was estimated and was found to be 0.95%, which could be one of the reasons for potent antioxidant activity exhibited by the plant. © 2004 Pharmaceutical Society of Japan.

AB - Anogeissus latifolia is widely used in the Indian indigenous system of medicine and is reported to contain leucocyanidins and tannoid principles like ellagic acid and its derivatives. In view of its wide use and its chemical composition, this study was aimed at examining the antioxidant activity of the extract of A. latifolia. The extract was studied for total antioxidant capacity, hydrogen-donating ability, nitric oxide, superoxide scavenging activity, hydrogen peroxide decomposition activity along with lipid peroxidation. Integral antioxidative capacity was determined by chemiluminescence assay. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat liver homogenate. The results indicate that A. latifolia extract has potent antioxidant activity. Also to ascertain the possible reason for the potent activity, percentage of gallic acid was estimated and was found to be 0.95%, which could be one of the reasons for potent antioxidant activity exhibited by the plant. © 2004 Pharmaceutical Society of Japan.

U2 - 10.1248/bpb.27.1266

DO - 10.1248/bpb.27.1266

M3 - Article

VL - 27

SP - 1266

EP - 1269

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 8

ER -

Govindarajan R, Vijayakumar M, Rao CV, Shirwaikar A, Rawat AKS, Mehrotra S et al. Antioxidant potential of Anogeissus latifolia. Biological and Pharmaceutical Bulletin. 2004;27(8):1266-1269. https://doi.org/10.1248/bpb.27.1266