Antioxidant potential of Eugenia jambolana seed; A randomized clinical trial in type 2 diabetes mellitus

G. Shivaprakash, M. R.S.M. Pai, M. Nandini, K. Reshma, D. A. Sahana, K. Rajendran, A. Shirwaikar, M. R. Adhikari, J. Ganesh

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Abstract

Diabetes mellitus (DM) is a growing global problem where, increased oxygen free radicals are responsible for the complications. Clinical evidence of Eugenia jambolana seeds for use in DM is lacking. This is an open labeled, randomized trial in DM patients: fifteen in group1 received Eugenia Jambolana seed powder 10 gm orally per day along with diet and exercise, and ten in group 2 on diet and exercise alone. Follow-up visits were: V0=randomization; V1-V6, after one to six months of therapy. Patients were followed up for blood sugar, glycosylated hemoglobin, fasting insulin, antioxidants from V0 to V6 in group 1 and V0 to V3 in group 2. Results revealed in group1: reduced Fasting blood sugar (FBS) fromV3-V6 [140(18), 125(26.5), 124(19.5), 134(24)]; rise in SOD (superoxide dismutase) at V3[3255(2394)] and V6[4650(3517)]; reduced HOMA-IR (homeostasis model assessment for insulin resistance) at V3 [5(6.8)] and V6 [5.5(3.3)]; negative correlation between SOD and FBS at V3(ρ= -0.5) and V6(ρ=-0.577) which were significant at (P<0.05). Study shows the antihyperglycemic and antioxidant potential of Eugenia jambolana seed powder and a negative correlation between the antioxidant and antihyperglycemic action.

Original languageEnglish
Pages (from-to)220-228
Number of pages9
JournalInternational Journal of Pharma and Bio Sciences
Volume2
Issue number2
Publication statusPublished - 01-12-2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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