Antioxidant properties of phenyl styryl ketones

D.V. Rajakumar, M.N.A. Rao

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Phenolic and non phenolic derivatives of phenyl styryl ketones were synthesized and evaluated as in vitro inhibitors of iron and cumene hydroperoxide dependent lipid peroxidation in rat brain homogenates. The compounds were also tested for antioxidant activity in phosphatidylcholine liposomes. Phenyl 3, 5-ditert-butyl-4-hydroxystyryl ketone was found to be the most potent inhibitor of peroxidation among all the compounds tested. It was found to be more active than vitamin E. It also reduced the stable free radical l,l-diphenyl-2-picrylhydrazyl to an appreciable extent. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Original languageUndefined/Unknown
Pages (from-to)309-317
Number of pages9
JournalFree Radical Research
Volume22
Issue number4
DOIs
Publication statusPublished - 1995

Cite this

Rajakumar, D.V. ; Rao, M.N.A. / Antioxidant properties of phenyl styryl ketones. In: Free Radical Research. 1995 ; Vol. 22, No. 4. pp. 309-317.
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Antioxidant properties of phenyl styryl ketones. / Rajakumar, D.V.; Rao, M.N.A.

In: Free Radical Research, Vol. 22, No. 4, 1995, p. 309-317.

Research output: Contribution to journalArticle

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AU - Rao, M.N.A.

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AB - Phenolic and non phenolic derivatives of phenyl styryl ketones were synthesized and evaluated as in vitro inhibitors of iron and cumene hydroperoxide dependent lipid peroxidation in rat brain homogenates. The compounds were also tested for antioxidant activity in phosphatidylcholine liposomes. Phenyl 3, 5-ditert-butyl-4-hydroxystyryl ketone was found to be the most potent inhibitor of peroxidation among all the compounds tested. It was found to be more active than vitamin E. It also reduced the stable free radical l,l-diphenyl-2-picrylhydrazyl to an appreciable extent. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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DO - 10.3109/10715769509145643

M3 - Article

VL - 22

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EP - 317

JO - Free Radical Research

JF - Free Radical Research

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