|Number of pages||6|
|Journal||Natural Product Sciences|
|Publication status||Published - 2007|
Antioxidant studies on the methanol stem extract of Coscinium fenestration. / Shirwaikar, A.; Punitha, I.S.R.In: Natural Product Sciences, Vol. 13, No. 1, 2007, p. 40-45.
Research output: Contribution to journal › Article
TY - JOUR
T1 - Antioxidant studies on the methanol stem extract of Coscinium fenestration
AU - Shirwaikar, A.
AU - Punitha, I.S.R.
N1 - Cited By :23 Export Date: 10 November 2017 CODEN: NPSCF Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka. 576 104, India; email: firstname.lastname@example.org Chemicals/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; methanol, 67-56-1; nitric oxide, 10102-43-9 References: Arora, A., Sairam, R.K., Srivastava, G.C., Oxidative stress and antioxidative system in plants (2002) Cur. Sci, 82, pp. 1227-1229; Badmis, S., Gupta, M.K., Suresh, B., Antioxidant activity of the ethanolic extract of Striga orobanchiodes (2003) J. Ethnopharmacol, 85, pp. 227-230; Beand-Williams, W., Cuvelier, M.E., Berset, C., Use of a free radical method to evaluate antioxidant activity (1995) Lebensm-Wiss Technol, 28, pp. 25-40; Benzie, I.F.F., Strain, J.T., The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power, the FRAP assay (1996) Anal. Biochem, 239, pp. 70-76; Benzie, I.F.F., Szeto, Y.T., Total antioxidant capacity of teas by the ferric reducing antioxidant power assay (1999) J. Agri. Food Chem, 47, pp. 633-636; Blois, Antioxidant determinations by the use of stable free radical (1958) Nature, 26, pp. 1199-1201; Chang, L.W., Yen, W.J., Huang, S.C., Duh, P.D., Antioxidant activity of sesame coat (2002) Food Chem, 78, pp. 347-354; Coscinium fenestratum, In: The Wealth of India, Publication Information and Directorate. India: CSIR, 2, 360 (1950); Cross, A.R., Jones, O.T.G., Enzymic mechanism of superoxide production (1991) Biochem. Biophys. Acta, 387, pp. 281-285; Cross, C.E., Oxygen radicals and human disease (1987) Annals of Internal Med, 107, pp. 526-529; Duh, P.D., Tu, Y.Y., Yen, G.C., Antioxidant activity of water extract of Harug Jyur (Chrysanthemum morifolium Ramat) (1999) Lebenmittel Wissenchaft und Technologie, 32, pp. 269-277; Geesin, J.G., Gordon, J.S., Berg, R.A., Retinoids affect collagen synthesis through inhibition of ascorbate induced lipid peroxidation in cultured human dermal fibroblasts (1990) Arch. Biochem. Biphy, 278, pp. 352-355; Gordon, M.H., The mechanism of the antioxidant action in vitro (1990) Food antioxidants, pp. 1-18. , Hudson, BJF Ed, Elseveir, London, pp; Govindarajan, R., Vijaya Kumar, M., Rao, C.V., Shirwaikar, A., Rawat, A.K.S., Mehrotra, S., Pushpagandan, P., Antioxidant potential of Anogiessus latifolia (2004) Biol. Pharm. Bull, 27 (8), pp. 1266-1269; Govindrarajan, R., Vijayakumar, M., Rawat, A.K.S., Mehrotra, S., Free radical scavenging potential of Picrrorhiza Kurroa Royle ex Benth (2003) Indian J. Exptl. Biol, 41, pp. 875-875; Halliwell, B., Reactive oxygen species in living systems: Source, biochemistry and role in human disease (1991) Am. J. Med, 91, pp. 14-22; Hussain, S.A., Ray, G., Oxidants, antioxidants and carcinogenesis (2002) Indian J. Exptl. Biol, 40, pp. 1213-1232; Ialenti, A., Moncada, S., Di Rosa, M., Modulation of adjuvant arthritis by endogenous nitric oxide (1993) British J. Pharmacol, 362, pp. 801-805; John, A., Steven, D.A., Microsomal lipid peroxidation (1984) Methods in Enzymol, 30, pp. 302-308; Kokate, C.K., Preliminary Phytochemical Screening (1986) Practical Pharmacognosy, pp. 111-115. , Vallabh Prakasan, Delhi, India, Ist Edition; Mahakunakorn, P., Tohda, M., Murakami, Y., Matsumoto, K., Watanabe, H., Antioxidant and free radical scavenging activity of Choto-san and its related constituents (2004) Biol. Pharm. Bull, 27 (1), pp. 38-46; Marcocci, L., Packer, L., Droy-Lefaiz, M.T., Sekaki, A., Gardes-Albert, M., Antioxidant actions of Ginko biloba extract Egb 761 (1958) Methods in Enzymol, 26, pp. 1199-1202; Marx, J.L., Oxygen free radicals linked to many diseases (1987) Science, 235, pp. 529-512; Molyneux, P., The use of stable free radical diphenyl picryl hydrazyl (DPPH) for estimating antioxidant activity (2004) Songklanakarin J. Sci. and Technol, 26 (2), pp. 212-219; Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C., Antioxidant activity applying an improved ABTS radical cation decolorization assay (1998) Free Radic. Biol. Med, 72, pp. 1231-1237; Rice-Evans, C., Miller, N.J., Factors affecting the antioxidant activity determined by the ABTS radical cation assay (1997) Free Radic. Res, 195, pp. 26-27; Sanchez-Moreno, C., Methods used to evaluate the free radical scavenging activity in foods and biological systems (2002) Food Sci. and Technol. Int, 8, pp. 122-126; Schlesier, K., Harwat, M., Bohm, V., Bitsch, R., Assessment of antioxidant activity by using different in vitro methods (2002) Free Radic. Res, 30 (2), pp. 177-185; Shirwaikar, A., Rajendran, K., Dinesh Kumar, C., In vitro antioxidant studies of Annona squamosa Linn. Leaves (2004) Indian J. Exptl. Biol, 42, pp. 803-807; Shirwaikar, A., Rajendran, K., Punitha, I.S.R., Antidiabetic activity of alcoholic stem extract of C. fenestratum in streptozotocin nicotinamide induced type 2 diabetic rats (2005) J. Ethnopharmacol, 97, pp. 369-374; Singh, G.B., Singh, S., Bani, S., Malhotra, S., Hypotensive action of a Coscinium fenestratum stem extract (1990) J. Ethnopharmacol, 38, pp. 151-155; Sreejayan, N., Rao, M.N.A., (a)., Nitric oxide scavenging by curcuminoids (1997) J. Pharm. Pharmacol, 49, pp. 105-107; Sreejayan, N., Rao, M.N.A., (b)., Free radical scavenging activity by curcuminoids (1996) Drug Res, 46, pp. 169-172; Venukumar, M.R., Latha, M.S., Antioxidant effect of Coscinium fenestratum in carbon tetra chloride treated rats (2002) Indian J. Physiol. Pharmacol, 46 (2), pp. 223-228; Venukumar, M.R., Latha, M.S., Effect of Coscinium fenestratum on hepatotoxicity in rats (2004) Indian J Exptl. 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PY - 2007
Y1 - 2007
N2 - The methanol extract of Coscinium fenestratum, commonly known as tree turmeric, which is widely used in the indigenous system of medicine was studied for its in vitro scavenging activity in different methods viz DPPH scavenging, nitric oxide scavenging, iron chelation activity, superoxide scavenging, ABTS radical scavenging and lipid peroxidation. The results were analyzed statistically by regression method. Its antioxidant activity was estimated by IC50 value and the values are 57.1 μg/ml for DPPH radical scavenging, 36.5 μg/ml for iron chelating activity, 51.7 μg/ml for nitric oxide scavenging, 53.63 μg/ml for ABTS scavenging, 44.2 μg/ml for superoxide scavenging, and 40 μg/ml for lipid peroxidation. In all the methods, the extract showed its ability to scavenge free radicals in a concentration dependent manner. The results indicate that C. fenestratum has potent antioxidant activity.
AB - The methanol extract of Coscinium fenestratum, commonly known as tree turmeric, which is widely used in the indigenous system of medicine was studied for its in vitro scavenging activity in different methods viz DPPH scavenging, nitric oxide scavenging, iron chelation activity, superoxide scavenging, ABTS radical scavenging and lipid peroxidation. The results were analyzed statistically by regression method. Its antioxidant activity was estimated by IC50 value and the values are 57.1 μg/ml for DPPH radical scavenging, 36.5 μg/ml for iron chelating activity, 51.7 μg/ml for nitric oxide scavenging, 53.63 μg/ml for ABTS scavenging, 44.2 μg/ml for superoxide scavenging, and 40 μg/ml for lipid peroxidation. In all the methods, the extract showed its ability to scavenge free radicals in a concentration dependent manner. The results indicate that C. fenestratum has potent antioxidant activity.
M3 - Article
VL - 13
SP - 40
EP - 45
JO - Natural Product Sciences
JF - Natural Product Sciences
SN - 1226-3907
IS - 1