Antioxidants and lipid peroxidation status in diabetic patients with and without complications

Rama Srivatsan, Sujata Das, Ranjita Gadde, Krishna Manoj-Kumar, Snigdha Taduri, Nageshwara Rao, B. Ramesh, Akanksha Baharani, Kaajal Shah, Srilakshmi C. Kamireddy, G. Priyatham, T. A. Balakumaran, Shubha Seshadri, Asha Kamath, Anjali Rao

Research output: Contribution to journalArticle

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Abstract

Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalArchives of Iranian Medicine
Volume12
Issue number2
Publication statusPublished - 2009

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Lipid Peroxidation
Antioxidants
Diabetes Mellitus
Ceruloplasmin
Thiobarbituric Acid Reactive Substances
Diabetes Complications
Glutathione Transferase
Vitamin E
Sulfhydryl Compounds
Ascorbic Acid
Superoxide Dismutase
Glutathione
Erythrocytes
Dietary Supplements
Vitamins
Type 2 Diabetes Mellitus
Free Radicals
Life Style
Reactive Oxygen Species
Oxidative Stress

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Srivatsan, R., Das, S., Gadde, R., Manoj-Kumar, K., Taduri, S., Rao, N., ... Rao, A. (2009). Antioxidants and lipid peroxidation status in diabetic patients with and without complications. Archives of Iranian Medicine, 12(2), 121-127.
Srivatsan, Rama ; Das, Sujata ; Gadde, Ranjita ; Manoj-Kumar, Krishna ; Taduri, Snigdha ; Rao, Nageshwara ; Ramesh, B. ; Baharani, Akanksha ; Shah, Kaajal ; Kamireddy, Srilakshmi C. ; Priyatham, G. ; Balakumaran, T. A. ; Seshadri, Shubha ; Kamath, Asha ; Rao, Anjali. / Antioxidants and lipid peroxidation status in diabetic patients with and without complications. In: Archives of Iranian Medicine. 2009 ; Vol. 12, No. 2. pp. 121-127.
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abstract = "Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.",
author = "Rama Srivatsan and Sujata Das and Ranjita Gadde and Krishna Manoj-Kumar and Snigdha Taduri and Nageshwara Rao and B. Ramesh and Akanksha Baharani and Kaajal Shah and Kamireddy, {Srilakshmi C.} and G. Priyatham and Balakumaran, {T. A.} and Shubha Seshadri and Asha Kamath and Anjali Rao",
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Srivatsan, R, Das, S, Gadde, R, Manoj-Kumar, K, Taduri, S, Rao, N, Ramesh, B, Baharani, A, Shah, K, Kamireddy, SC, Priyatham, G, Balakumaran, TA, Seshadri, S, Kamath, A & Rao, A 2009, 'Antioxidants and lipid peroxidation status in diabetic patients with and without complications', Archives of Iranian Medicine, vol. 12, no. 2, pp. 121-127.

Antioxidants and lipid peroxidation status in diabetic patients with and without complications. / Srivatsan, Rama; Das, Sujata; Gadde, Ranjita; Manoj-Kumar, Krishna; Taduri, Snigdha; Rao, Nageshwara; Ramesh, B.; Baharani, Akanksha; Shah, Kaajal; Kamireddy, Srilakshmi C.; Priyatham, G.; Balakumaran, T. A.; Seshadri, Shubha; Kamath, Asha; Rao, Anjali.

In: Archives of Iranian Medicine, Vol. 12, No. 2, 2009, p. 121-127.

Research output: Contribution to journalArticle

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T1 - Antioxidants and lipid peroxidation status in diabetic patients with and without complications

AU - Srivatsan, Rama

AU - Das, Sujata

AU - Gadde, Ranjita

AU - Manoj-Kumar, Krishna

AU - Taduri, Snigdha

AU - Rao, Nageshwara

AU - Ramesh, B.

AU - Baharani, Akanksha

AU - Shah, Kaajal

AU - Kamireddy, Srilakshmi C.

AU - Priyatham, G.

AU - Balakumaran, T. A.

AU - Seshadri, Shubha

AU - Kamath, Asha

AU - Rao, Anjali

PY - 2009

Y1 - 2009

N2 - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

AB - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.

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Srivatsan R, Das S, Gadde R, Manoj-Kumar K, Taduri S, Rao N et al. Antioxidants and lipid peroxidation status in diabetic patients with and without complications. Archives of Iranian Medicine. 2009;12(2):121-127.