TY - JOUR
T1 - Antioxidants and lipid peroxidation status in diabetic patients with and without complications
AU - Srivatsan, Rama
AU - Das, Sujata
AU - Gadde, Ranjita
AU - Manoj-Kumar, Krishna
AU - Taduri, Snigdha
AU - Rao, Nageshwara
AU - Ramesh, B.
AU - Baharani, Akanksha
AU - Shah, Kaajal
AU - Kamireddy, Srilakshmi C.
AU - Priyatham, G.
AU - Balakumaran, T. A.
AU - Seshadri, Shubha
AU - Kamath, Asha
AU - Rao, Anjali
PY - 2009
Y1 - 2009
N2 - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.
AB - Background: Oxidative stress is involved in the pathophysiology of diabetes mellitus. Methods: In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectrophotometer. Results: A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. Conclusion: In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus.
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M3 - Article
C2 - 19249880
AN - SCOPUS:67649827502
SN - 1029-2977
VL - 12
SP - 121
EP - 127
JO - Archives of Iranian Medicine
JF - Archives of Iranian Medicine
IS - 2
ER -
