Abstract

Objective: To investigate the antipyretic and analgesic activity of dry residue of leaf juice of Solanum melongena. Methods: The preliminary phytochemical screening of the dry residue was carried out by chemical tests, spectrophotometric and thin layer chromatographic methods. Acute toxicity study was performed in mice after administration of the dry residue orally in graded doses (0.5-4 g/kg body weight). Antipyretic activity of dry residue of S. melongena (100, 250 and 500 mg/kg doses) was carried out on yeast induced pyrexia in rats. Analgesic activity of dry residue was evaluated in mice using the acetic acid induced writhing test at 100, 250 and 500 mg/kg doses. Results: The preliminary phytochemical screening of the dry residue showed the presence of flavonoids, alkaloids, tannins and steroids. In acute toxicity study, no mortality was observed at a dose as high as 4 g/kg. The dry residue of fresh juice produced significant antipyretic effect in a dose dependent manner and an appreciable antipyretic effect was noticed at 500 mg/kg dose. A dose dependent analgesic activity was observed with S. melongena and significant effect was observed at 500 mg/kg dose. Conclusion: The present study demonstrates the potential antipyretic and analgesic effect of S. melongena further supporting the claims by traditional medicine practitioners.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalIndian Journal of Pharmacology
Volume35
Issue number5
Publication statusPublished - 10-2003

Fingerprint

Solanum melongena
Antipyretics
Analgesics
Rodentia
Phytochemicals
Tannins
Traditional Medicine
Alkaloids
Flavonoids
Acetic Acid
Fever
Yeasts
Steroids
Body Weight
Mortality

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{1fa74dfaf2624885a46c0daa5c89ae8b,
title = "Antipyretic and analgesic effect of leaves of Solanum melongena Linn. in Rodents",
abstract = "Objective: To investigate the antipyretic and analgesic activity of dry residue of leaf juice of Solanum melongena. Methods: The preliminary phytochemical screening of the dry residue was carried out by chemical tests, spectrophotometric and thin layer chromatographic methods. Acute toxicity study was performed in mice after administration of the dry residue orally in graded doses (0.5-4 g/kg body weight). Antipyretic activity of dry residue of S. melongena (100, 250 and 500 mg/kg doses) was carried out on yeast induced pyrexia in rats. Analgesic activity of dry residue was evaluated in mice using the acetic acid induced writhing test at 100, 250 and 500 mg/kg doses. Results: The preliminary phytochemical screening of the dry residue showed the presence of flavonoids, alkaloids, tannins and steroids. In acute toxicity study, no mortality was observed at a dose as high as 4 g/kg. The dry residue of fresh juice produced significant antipyretic effect in a dose dependent manner and an appreciable antipyretic effect was noticed at 500 mg/kg dose. A dose dependent analgesic activity was observed with S. melongena and significant effect was observed at 500 mg/kg dose. Conclusion: The present study demonstrates the potential antipyretic and analgesic effect of S. melongena further supporting the claims by traditional medicine practitioners.",
author = "S. Mutalik and K. Paridhavi and Rao, {C. Mallikarjuna} and N. Udupa",
note = "Cited By :43 Export Date: 10 November 2017 CODEN: INJPD Correspondence Address: Udupa, N.; College of Pharmaceutical Sci., Manipal 576 119, India; email: udupa1553@yahoo.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; paracetamol, 103-90-2; sodium chloride, 7647-14-5 References: Warrier, P.K., Nambiar, V.P.K., Rammanakutty, C., (1996) Indian Medicinal Plants, , Madras (India): Orient Longman Publishers Limited; Sudheesh, S., Sandhya, C., Koshy, S.A., Vijayalakshmi, N.R., Antioxidant activity of flavonoids from Solanum melongena (1999) Phytother Res, 13, pp. 393-396; Noda, Y., Kaneyuke, T., Igarashi, K., Mori, A., Packer, L., Antioxidant activity of nasunin, an anthocyanin in egg plant (1998) Res Comm Med Pathol Pharmacol, 102, pp. 175-187; Vohera, S.B., Kumar, I., Khan, M.S., Effect of alkaloids of Solanum melongena on the central nervous system (1984) J Ethnopharmacol, 11, pp. 331-336; Sudheesh, S., Kumar, P., Kumar, V., Vijayalakashmi, N.R., Hypolipidemic effect of flavonoids from Solanum melongena (1997) Plant Food Human Nutr, 51, pp. 321-330; Horborne, J.B., (1984) Phytochemical Methods, , London (UK): Chapman and Hall Publishers; Rao, R.R., Babu, R.M., Rao, M.R.V., Babu, M.G.V., Studies on antipyretic, analgesic and hypoglycemic activities of root of Gynandropsis gynandra Linn (1997) Ind Drugs, 34, pp. 690-693; Hossinzadeh, H., Ramezani, M., Fadishei, M., Mahmoudi, M., Antinociceptive, antiinflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats (2002) Phytomedicine, 9, pp. 135-141; Brasseur, T., Antiinflammatory properties of flavonoids (1989) J Pharm Belg, 44, pp. 235-241; Vimala, R., Nagarajan, S., Alam, M., Susan, T., Joy, S., Antiinflammatory and antipyretic activity of Michelia champaca Linn., (white variety), Ixora brachiata Roxb. and Rhynchosia cana (Willd.) D.C. flower extract (1997) Indian J Exp Biol, 35, pp. 1310-1314; Brzezinska, S.E., Fever induced oxidative stress: The effect on thyroid status and the 5′-mono deiodinase activity, protective role of selenium and vitamin E (2001) J Physiol Pharmacol, 52, pp. 275-284; Dewan, S., Kumar, S., Kumar, V., Antipyretic effect of latex of Calotropis proceara (2000) Indian J Pharmacol, 32, p. 252",
year = "2003",
month = "10",
language = "English",
volume = "35",
pages = "312--315",
journal = "Indian Journal of Pharmacology",
issn = "0253-7613",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "5",

}

Antipyretic and analgesic effect of leaves of Solanum melongena Linn. in Rodents. / Mutalik, S.; Paridhavi, K.; Rao, C. Mallikarjuna; Udupa, N.

In: Indian Journal of Pharmacology, Vol. 35, No. 5, 10.2003, p. 312-315.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antipyretic and analgesic effect of leaves of Solanum melongena Linn. in Rodents

AU - Mutalik, S.

AU - Paridhavi, K.

AU - Rao, C. Mallikarjuna

AU - Udupa, N.

N1 - Cited By :43 Export Date: 10 November 2017 CODEN: INJPD Correspondence Address: Udupa, N.; College of Pharmaceutical Sci., Manipal 576 119, India; email: udupa1553@yahoo.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; paracetamol, 103-90-2; sodium chloride, 7647-14-5 References: Warrier, P.K., Nambiar, V.P.K., Rammanakutty, C., (1996) Indian Medicinal Plants, , Madras (India): Orient Longman Publishers Limited; Sudheesh, S., Sandhya, C., Koshy, S.A., Vijayalakshmi, N.R., Antioxidant activity of flavonoids from Solanum melongena (1999) Phytother Res, 13, pp. 393-396; Noda, Y., Kaneyuke, T., Igarashi, K., Mori, A., Packer, L., Antioxidant activity of nasunin, an anthocyanin in egg plant (1998) Res Comm Med Pathol Pharmacol, 102, pp. 175-187; Vohera, S.B., Kumar, I., Khan, M.S., Effect of alkaloids of Solanum melongena on the central nervous system (1984) J Ethnopharmacol, 11, pp. 331-336; Sudheesh, S., Kumar, P., Kumar, V., Vijayalakashmi, N.R., Hypolipidemic effect of flavonoids from Solanum melongena (1997) Plant Food Human Nutr, 51, pp. 321-330; Horborne, J.B., (1984) Phytochemical Methods, , London (UK): Chapman and Hall Publishers; Rao, R.R., Babu, R.M., Rao, M.R.V., Babu, M.G.V., Studies on antipyretic, analgesic and hypoglycemic activities of root of Gynandropsis gynandra Linn (1997) Ind Drugs, 34, pp. 690-693; Hossinzadeh, H., Ramezani, M., Fadishei, M., Mahmoudi, M., Antinociceptive, antiinflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats (2002) Phytomedicine, 9, pp. 135-141; Brasseur, T., Antiinflammatory properties of flavonoids (1989) J Pharm Belg, 44, pp. 235-241; Vimala, R., Nagarajan, S., Alam, M., Susan, T., Joy, S., Antiinflammatory and antipyretic activity of Michelia champaca Linn., (white variety), Ixora brachiata Roxb. and Rhynchosia cana (Willd.) D.C. flower extract (1997) Indian J Exp Biol, 35, pp. 1310-1314; Brzezinska, S.E., Fever induced oxidative stress: The effect on thyroid status and the 5′-mono deiodinase activity, protective role of selenium and vitamin E (2001) J Physiol Pharmacol, 52, pp. 275-284; Dewan, S., Kumar, S., Kumar, V., Antipyretic effect of latex of Calotropis proceara (2000) Indian J Pharmacol, 32, p. 252

PY - 2003/10

Y1 - 2003/10

N2 - Objective: To investigate the antipyretic and analgesic activity of dry residue of leaf juice of Solanum melongena. Methods: The preliminary phytochemical screening of the dry residue was carried out by chemical tests, spectrophotometric and thin layer chromatographic methods. Acute toxicity study was performed in mice after administration of the dry residue orally in graded doses (0.5-4 g/kg body weight). Antipyretic activity of dry residue of S. melongena (100, 250 and 500 mg/kg doses) was carried out on yeast induced pyrexia in rats. Analgesic activity of dry residue was evaluated in mice using the acetic acid induced writhing test at 100, 250 and 500 mg/kg doses. Results: The preliminary phytochemical screening of the dry residue showed the presence of flavonoids, alkaloids, tannins and steroids. In acute toxicity study, no mortality was observed at a dose as high as 4 g/kg. The dry residue of fresh juice produced significant antipyretic effect in a dose dependent manner and an appreciable antipyretic effect was noticed at 500 mg/kg dose. A dose dependent analgesic activity was observed with S. melongena and significant effect was observed at 500 mg/kg dose. Conclusion: The present study demonstrates the potential antipyretic and analgesic effect of S. melongena further supporting the claims by traditional medicine practitioners.

AB - Objective: To investigate the antipyretic and analgesic activity of dry residue of leaf juice of Solanum melongena. Methods: The preliminary phytochemical screening of the dry residue was carried out by chemical tests, spectrophotometric and thin layer chromatographic methods. Acute toxicity study was performed in mice after administration of the dry residue orally in graded doses (0.5-4 g/kg body weight). Antipyretic activity of dry residue of S. melongena (100, 250 and 500 mg/kg doses) was carried out on yeast induced pyrexia in rats. Analgesic activity of dry residue was evaluated in mice using the acetic acid induced writhing test at 100, 250 and 500 mg/kg doses. Results: The preliminary phytochemical screening of the dry residue showed the presence of flavonoids, alkaloids, tannins and steroids. In acute toxicity study, no mortality was observed at a dose as high as 4 g/kg. The dry residue of fresh juice produced significant antipyretic effect in a dose dependent manner and an appreciable antipyretic effect was noticed at 500 mg/kg dose. A dose dependent analgesic activity was observed with S. melongena and significant effect was observed at 500 mg/kg dose. Conclusion: The present study demonstrates the potential antipyretic and analgesic effect of S. melongena further supporting the claims by traditional medicine practitioners.

UR - http://www.scopus.com/inward/record.url?scp=0142074840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142074840&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 312

EP - 315

JO - Indian Journal of Pharmacology

JF - Indian Journal of Pharmacology

SN - 0253-7613

IS - 5

ER -