Antitumor and antifertility activities of plumbagin controlled release formulations

D. P. Kini, S. Pandey, B. D. Shenoy, U. V. Singh, N. Udupa, P. Umadevi, R. Kamath, Nagarajkumari, K. Ramanarayan

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Abstract

With a view to increase efficiency and reduce toxicity of Plumbagin, an attempt was made to formulate plumbagin as a controlled release preparation using various carriers and test for their antitumor and antifertility activities. Niosomes and albumin microspheres were used as carriers. In vitro data showed promising results for these formulations thus they were taken up for in vivo assessment. Given at a dose of 5 mg/kg, ip the albumin microspheres showed promising antitumor and antifertility activity when compared to the niosomes or control. Animal survival data also indicated slight improvement in survival rate and thus antitumoral activity. Also, an interesting point was that the antifertility activity was affected through an antiovulatory action as seen from histopathological studies.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalIndian Journal of Experimental Biology
Volume35
Issue number4
Publication statusPublished - 04-1997

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

Kini, D. P., Pandey, S., Shenoy, B. D., Singh, U. V., Udupa, N., Umadevi, P., Kamath, R., Nagarajkumari, & Ramanarayan, K. (1997). Antitumor and antifertility activities of plumbagin controlled release formulations. Indian Journal of Experimental Biology, 35(4), 374-379.