Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1

Elsie Oommen, B. Dinesh Shenoy, N. Udupa, Ravindra Kamath, P. Uma Devi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An inclusion complex of plumbagin with β-cyclodextrin was prepared with a view to increasing the aqueous solubility and stability of the drug. The drug complex and the free drug were entrapped in niosomes using a lipid layer hydration method with cholesterol, Span 60 and dicetyl phosphate. The niosomal entrapment efficiency of the drug complex was 74%, with the drug being incorporated into the aqueous layer of the vesicle. When administered subcutaneously to C57BL/6J mice bearing melanoma B16F1 at a dose of 5 mg kg-1, the niosome entrapped drug complex had improved anticancer activity as evidenced by the enhanced volume doubling time and growth delay. Complexation with cyclodextrin increases the solubility and stability of plumbagin and also its efficacy. These effects were more pronounced when the complex was entrapped in the nonionic surfactant vesicles.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalPharmacy and Pharmacology Communications
Volume5
Issue number4
Publication statusPublished - 1999

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Cyclodextrins
Liposomes
Melanoma
Pharmaceutical Preparations
Solubility
Drug Stability
Inbred C57BL Mouse
Surface-Active Agents
Cholesterol
plumbagin
Lipids
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Oommen, Elsie ; Shenoy, B. Dinesh ; Udupa, N. ; Kamath, Ravindra ; Uma Devi, P. / Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1. In: Pharmacy and Pharmacology Communications. 1999 ; Vol. 5, No. 4. pp. 281-285.
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Antitumour efficacy of cyclodextrin-complexed and niosome-encapsulated plumbagin in mice bearing melanoma B16F1. / Oommen, Elsie; Shenoy, B. Dinesh; Udupa, N.; Kamath, Ravindra; Uma Devi, P.

In: Pharmacy and Pharmacology Communications, Vol. 5, No. 4, 1999, p. 281-285.

Research output: Contribution to journalArticle

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