The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).
|Number of pages||13|
|Publication status||Published - 2009|