Antiulcer activity of aqueous extract of Avipattikar churna

H.N. Aswatha Ram, U. Kaushik, P. Lachake, C.S. Shreedhara, B. Sathyanarayana

Research output: Contribution to journalArticle

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Abstract

The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).
Original languageEnglish
Pages (from-to)1169-1181
Number of pages13
JournalPharmacologyonline
Volume1
Publication statusPublished - 2009

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Ibuprofen
Pylorus
Stomach
Ulcer
Ligation
Ethanol
Ranitidine
Gastric Acid
Stomach Ulcer
Oral Administration
Mucous Membrane
Acids

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Aswatha Ram, H. N., Kaushik, U., Lachake, P., Shreedhara, C. S., & Sathyanarayana, B. (2009). Antiulcer activity of aqueous extract of Avipattikar churna. Pharmacologyonline, 1, 1169-1181.
Aswatha Ram, H.N. ; Kaushik, U. ; Lachake, P. ; Shreedhara, C.S. ; Sathyanarayana, B. / Antiulcer activity of aqueous extract of Avipattikar churna. In: Pharmacologyonline. 2009 ; Vol. 1. pp. 1169-1181.
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abstract = "The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).",
author = "{Aswatha Ram}, H.N. and U. Kaushik and P. Lachake and C.S. Shreedhara and B. Sathyanarayana",
note = "Cited By :1 Export Date: 10 November 2017 Correspondence Address: Aswatha Ram, H.N.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal - 576 104 Kanataka, India; email: aswatharam@gmail.com Chemicals/CAS: alcohol, 64-17-5; ibuprofen, 15687-27-1; ranitidine, 66357-35-5, 66357-59-3 References: Formulary of Ayurvedic medicine, , 2nd edition. Anonymous; Shri rajeshwaradatta shastri, Bhaisajyaratnavali of Shri Govinddas, 18th edition, 922; Kannapan, (2008) Antiulcer activity of methanolic extract of Jatropha Curcas (Linn.) on Aspirin induced gastric lesions in Wistar rats, Pharmacologyonline, 1, pp. 279-293; Ghosh, M.N., (1984) Fundamentals of experimental pharmacology, p. 153. , Scientific Book agency, Calcutta; Turner, M.A., (1956) Screening method in pharmacology, p. 26. , Academic Press, New York; Rao, C.M., Ramesh, K.V., Bairy, K.L., Kulkarni, D.R., Zinc complexes of NSAID's abolish gastric ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 64; Mallikarjuna Rao, C., Ramesh, K.V., Bairy, K.L., Kulkarni, D., Zinc complexes of NSAID's abolish gastric IC ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 67; Morimoto, Y., Shimohara, K., Oshima, S., Sukamato, T., Effects of the new antiulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine (1991) Japanese Pharmacol, 57, p. 495; Shay, H., Komarow, S.A., Fels, S.S., Meranze, D., Gruenstein, M., Siplet, H.A., (1945) Gastroentrology, 5, p. 43; Hawk, (1965) Hawk's physiological chemistry, p. 483. , Oster B L, ed. Mac Graw Hill Book Co; Goburdhan R, Gulrez, Haruna H and West G B. J. Pharmacol. Meth., 1 (1978) 109-114; Rainsford and Whitehouse (1976) Cited by Oternese I G and Bliven M J. In NSAIDs, Lambardino J C. Ed. (Awiley - Inter Science Publication, New York), (1985) 142; Drury, R.A.B., Wellington, E.A., Carleton's histopathological technique (1976) Oxford University Press, p. 85. , 4th edition, London; Andrew, H., Soll, M.D., Pathogenesis of peptic ulcer and implication of therapy, The New (1990) England J Med, 322, p. 909; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogenesis of peptic ulcer disease and current trends in therapy (1997) Indian J Physiol Pharmacol, 41, p. 3; Soll, A.H., Pathogenesis of peptic ulcer and implications for therapy, The New (1990) England J Med, 322, p. 909; Bandyopadhyay, U., Das, D., Bandyopadya, D., Bhattacharjee, M., banerjee, R.K., Role of reactive oxygen species in mercaptomethyllimidazole - induced gastric acid secretion and stress - induced gastric ulceration (1999) Curr Sci, 76, p. 55; Naito, Y., Yoshikawa, T., Matusyama, K., Yagi, N., Aral, M., Nakamura, S., Yoshioda, N., Konda, M., Effect of oxygen radical scavengers on the quality of gastric healing in rats (1995) Clinic Gastroenterol, 21, pp. S82; Vander Laan, L., Kapitein, P.J., Oyen, W.J., Verhofstad, A.A., Hendriks, T., Goris, R.J., A novel animal model to evaluate oxygen derived free radical damage in soft tissue (1997) Free Radical Research, 26, p. 363; Oates, P.J., Hakkinen, J.P., Studies on the mechanism ethanol-induced gastric damage in rats (1988) Gastroenterology, 94, p. 10; Mizui, T., Sato, H., Hiros, F., Doteuchi, M., Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats (1987) Life Sci, 41, p. 755; Peskar, B.M., Lange, K., Hoppe, U., Peskar, B.A., Ethanol stimulates formation of leukotrienes C4 in rat gastric mucosa (1986) Prostaglandins, 31, p. 283; Szelenyi, L., Brune, K., Possible role of oxygen free radical in ethanol induced gastric-mucosal damage in rats (1988) Dig Dis Sci, 33, pp. 865-871",
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Aswatha Ram, HN, Kaushik, U, Lachake, P, Shreedhara, CS & Sathyanarayana, B 2009, 'Antiulcer activity of aqueous extract of Avipattikar churna', Pharmacologyonline, vol. 1, pp. 1169-1181.

Antiulcer activity of aqueous extract of Avipattikar churna. / Aswatha Ram, H.N.; Kaushik, U.; Lachake, P.; Shreedhara, C.S.; Sathyanarayana, B.

In: Pharmacologyonline, Vol. 1, 2009, p. 1169-1181.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antiulcer activity of aqueous extract of Avipattikar churna

AU - Aswatha Ram, H.N.

AU - Kaushik, U.

AU - Lachake, P.

AU - Shreedhara, C.S.

AU - Sathyanarayana, B.

N1 - Cited By :1 Export Date: 10 November 2017 Correspondence Address: Aswatha Ram, H.N.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal - 576 104 Kanataka, India; email: aswatharam@gmail.com Chemicals/CAS: alcohol, 64-17-5; ibuprofen, 15687-27-1; ranitidine, 66357-35-5, 66357-59-3 References: Formulary of Ayurvedic medicine, , 2nd edition. Anonymous; Shri rajeshwaradatta shastri, Bhaisajyaratnavali of Shri Govinddas, 18th edition, 922; Kannapan, (2008) Antiulcer activity of methanolic extract of Jatropha Curcas (Linn.) on Aspirin induced gastric lesions in Wistar rats, Pharmacologyonline, 1, pp. 279-293; Ghosh, M.N., (1984) Fundamentals of experimental pharmacology, p. 153. , Scientific Book agency, Calcutta; Turner, M.A., (1956) Screening method in pharmacology, p. 26. , Academic Press, New York; Rao, C.M., Ramesh, K.V., Bairy, K.L., Kulkarni, D.R., Zinc complexes of NSAID's abolish gastric ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 64; Mallikarjuna Rao, C., Ramesh, K.V., Bairy, K.L., Kulkarni, D., Zinc complexes of NSAID's abolish gastric IC ulceration propensity of parent drug (1990) Indian Drugs, 28, p. 67; Morimoto, Y., Shimohara, K., Oshima, S., Sukamato, T., Effects of the new antiulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine (1991) Japanese Pharmacol, 57, p. 495; Shay, H., Komarow, S.A., Fels, S.S., Meranze, D., Gruenstein, M., Siplet, H.A., (1945) Gastroentrology, 5, p. 43; Hawk, (1965) Hawk's physiological chemistry, p. 483. , Oster B L, ed. Mac Graw Hill Book Co; Goburdhan R, Gulrez, Haruna H and West G B. J. Pharmacol. Meth., 1 (1978) 109-114; Rainsford and Whitehouse (1976) Cited by Oternese I G and Bliven M J. In NSAIDs, Lambardino J C. Ed. (Awiley - Inter Science Publication, New York), (1985) 142; Drury, R.A.B., Wellington, E.A., Carleton's histopathological technique (1976) Oxford University Press, p. 85. , 4th edition, London; Andrew, H., Soll, M.D., Pathogenesis of peptic ulcer and implication of therapy, The New (1990) England J Med, 322, p. 909; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogenesis of peptic ulcer disease and current trends in therapy (1997) Indian J Physiol Pharmacol, 41, p. 3; Soll, A.H., Pathogenesis of peptic ulcer and implications for therapy, The New (1990) England J Med, 322, p. 909; Bandyopadhyay, U., Das, D., Bandyopadya, D., Bhattacharjee, M., banerjee, R.K., Role of reactive oxygen species in mercaptomethyllimidazole - induced gastric acid secretion and stress - induced gastric ulceration (1999) Curr Sci, 76, p. 55; Naito, Y., Yoshikawa, T., Matusyama, K., Yagi, N., Aral, M., Nakamura, S., Yoshioda, N., Konda, M., Effect of oxygen radical scavengers on the quality of gastric healing in rats (1995) Clinic Gastroenterol, 21, pp. S82; Vander Laan, L., Kapitein, P.J., Oyen, W.J., Verhofstad, A.A., Hendriks, T., Goris, R.J., A novel animal model to evaluate oxygen derived free radical damage in soft tissue (1997) Free Radical Research, 26, p. 363; Oates, P.J., Hakkinen, J.P., Studies on the mechanism ethanol-induced gastric damage in rats (1988) Gastroenterology, 94, p. 10; Mizui, T., Sato, H., Hiros, F., Doteuchi, M., Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats (1987) Life Sci, 41, p. 755; Peskar, B.M., Lange, K., Hoppe, U., Peskar, B.A., Ethanol stimulates formation of leukotrienes C4 in rat gastric mucosa (1986) Prostaglandins, 31, p. 283; Szelenyi, L., Brune, K., Possible role of oxygen free radical in ethanol induced gastric-mucosal damage in rats (1988) Dig Dis Sci, 33, pp. 865-871

PY - 2009

Y1 - 2009

N2 - The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).

AB - The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).

M3 - Article

VL - 1

SP - 1169

EP - 1181

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -

Aswatha Ram HN, Kaushik U, Lachake P, Shreedhara CS, Sathyanarayana B. Antiulcer activity of aqueous extract of Avipattikar churna. Pharmacologyonline. 2009;1:1169-1181.