The objective of the study was to investigate anti ulcer activity of petroleum ether, alcohol and aqueous extracts of stem of Tinospora malabarica (Lamk.). All the three extracts were subjected to preliminary phytochemical investigation and also for acute oral toxicity study. The preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates and amino acids in aqueous extract, flavonoids, alkaloids and carbohydrates in alcoholic extract, while petroleum ether extract contains only steroids. Aqueous and alcohol extracts found to be non toxic upto a dose of 5000 mg/kg while petroleum ether extract was safe up to a dose of 2000 mg/kg after single dose administration of the extract. Present study showed that, there was significant reduction in the ulcer index with aqueous and alcoholic extract and with that of petroleum ether it was less significant, also their was a considerable reduction in the free as well as the total acidity in pylorus ligated rats. In case of stress induced ulcers there was a significant reduction in ulcer index wit all the three extracts and percentage protection of aqueous extract was nearly equivalent with that of standard.
|Number of pages||6|
|Publication status||Published - 2009|
Khayum, M. A., Nandakumar, K., Gouda, T. S., Khalid, S. M., Venkat Rao, N., & Kumar, S. M. S. (2009). Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.). Pharmacologyonline, 1, 885-890.