Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.)

M.A. Khayum, K. Nandakumar, T.S. Gouda, S.M. Khalid, N. Venkat Rao, S.M.S. Kumar

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Abstract

The objective of the study was to investigate anti ulcer activity of petroleum ether, alcohol and aqueous extracts of stem of Tinospora malabarica (Lamk.). All the three extracts were subjected to preliminary phytochemical investigation and also for acute oral toxicity study. The preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates and amino acids in aqueous extract, flavonoids, alkaloids and carbohydrates in alcoholic extract, while petroleum ether extract contains only steroids. Aqueous and alcohol extracts found to be non toxic upto a dose of 5000 mg/kg while petroleum ether extract was safe up to a dose of 2000 mg/kg after single dose administration of the extract. Present study showed that, there was significant reduction in the ulcer index with aqueous and alcoholic extract and with that of petroleum ether it was less significant, also their was a considerable reduction in the free as well as the total acidity in pylorus ligated rats. In case of stress induced ulcers there was a significant reduction in ulcer index wit all the three extracts and percentage protection of aqueous extract was nearly equivalent with that of standard.
Original languageEnglish
Pages (from-to)885-890
Number of pages6
JournalPharmacologyonline
Volume1
Publication statusPublished - 2009

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Tinospora
Ulcer
Phytochemicals
Flavonoids
Alcohols
Carbohydrates
Wit and Humor
Poisons
Pylorus
Alkaloids
Steroids
Amino Acids
naphtha

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Khayum, M. A., Nandakumar, K., Gouda, T. S., Khalid, S. M., Venkat Rao, N., & Kumar, S. M. S. (2009). Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.). Pharmacologyonline, 1, 885-890.
Khayum, M.A. ; Nandakumar, K. ; Gouda, T.S. ; Khalid, S.M. ; Venkat Rao, N. ; Kumar, S.M.S. / Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.). In: Pharmacologyonline. 2009 ; Vol. 1. pp. 885-890.
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abstract = "The objective of the study was to investigate anti ulcer activity of petroleum ether, alcohol and aqueous extracts of stem of Tinospora malabarica (Lamk.). All the three extracts were subjected to preliminary phytochemical investigation and also for acute oral toxicity study. The preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates and amino acids in aqueous extract, flavonoids, alkaloids and carbohydrates in alcoholic extract, while petroleum ether extract contains only steroids. Aqueous and alcohol extracts found to be non toxic upto a dose of 5000 mg/kg while petroleum ether extract was safe up to a dose of 2000 mg/kg after single dose administration of the extract. Present study showed that, there was significant reduction in the ulcer index with aqueous and alcoholic extract and with that of petroleum ether it was less significant, also their was a considerable reduction in the free as well as the total acidity in pylorus ligated rats. In case of stress induced ulcers there was a significant reduction in ulcer index wit all the three extracts and percentage protection of aqueous extract was nearly equivalent with that of standard.",
author = "M.A. Khayum and K. Nandakumar and T.S. Gouda and S.M. Khalid and {Venkat Rao}, N. and S.M.S. Kumar",
note = "Cited By :9 Export Date: 10 November 2017 Correspondence Address: Khayum, M.A.; Department of Pharmacology, V.L. College of Pharmacy, Raichur, Karnataka, India; email: Khayumblack@gmail.com Chemicals/CAS: amino acid, 65072-01-7; ranitidine, 66357-35-5, 66357-59-3 References: Synleh, (1976) Synle guide to stress research, , Newyork: Von Nos trand;; Dadkar, V.N., Joshi, A.G., Jaguste, V.S., Billmoria FR, Dhar H.L. Antistress activity of Ocimum sanctum (Linn) (1987) Indian Drugs, 25 (5), pp. 172-175; Sanyal, A.K., Mitra, P.K., Goel, R.K., A modified method to estimate dissolved mucosubstances in gastric juice (1983) Indian J Exp Biol, 21, pp. 78-80; Freston, J.W., Overview of medicinal therapy of peptic ulcer disease (1990) Gastroenterol Clin North Am, 19, pp. 121-140; Robert, A., Current history of cytoprotection (1981) Gastroenterology, 21, pp. 78-80; Marini-Bettolo, G.B., Present aspects of the use of medicinal plants in traditional medicine (1980) J Ethnopharmacol, 2, pp. 5-7; Sen, P., Maiti, P.C., Puri, S., Ray, A., Audulov, N.A., Valdman, A.V., Mechanism of antistress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals (1992) Indian J Exp Biol, 30 (7), pp. 592-596. , Jul;; Brijmohan Sharma, T., Shivaraj Gouda, N., Venkat Rao, M., Shalam, SM Shantakumar, M.Laxmi Narasu A study on adaptogenic activity of stem extracts Of Tinospora malabarica (lamk) (2007) Pharmacologyonline, 1, pp. 349-358; Khandelwal KR. Practical pharmacognosy techniques and experiment.2nd edition Pune: Nirali prakashan 2000; 149-56; Gerhard Vogel, H., (2002) Drug Discovery and Evaluation, p. 867. , 2nd ed. New York. Springer-Verlag Berlin Heidelberg; Kulkarni, S.K., (1999) Handbook of Experimental Pharmacology, pp. 148-150. , 3rd ed. New Delhi Vallabh Prakashan;; Alder, R., (1984) Breakdown in Human Adptation to stress, p. 653. , Boston: Martinus Ninjihoff;; Goel, R.K., Bhattachariya, S.K., Gastro duodenal mucosal defense and mucosal protective agents (1991) Indian J Expl Biol, 29, pp. 701-714",
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Khayum, MA, Nandakumar, K, Gouda, TS, Khalid, SM, Venkat Rao, N & Kumar, SMS 2009, 'Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.)', Pharmacologyonline, vol. 1, pp. 885-890.

Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.). / Khayum, M.A.; Nandakumar, K.; Gouda, T.S.; Khalid, S.M.; Venkat Rao, N.; Kumar, S.M.S.

In: Pharmacologyonline, Vol. 1, 2009, p. 885-890.

Research output: Contribution to journalArticle

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AU - Gouda, T.S.

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N1 - Cited By :9 Export Date: 10 November 2017 Correspondence Address: Khayum, M.A.; Department of Pharmacology, V.L. College of Pharmacy, Raichur, Karnataka, India; email: Khayumblack@gmail.com Chemicals/CAS: amino acid, 65072-01-7; ranitidine, 66357-35-5, 66357-59-3 References: Synleh, (1976) Synle guide to stress research, , Newyork: Von Nos trand;; Dadkar, V.N., Joshi, A.G., Jaguste, V.S., Billmoria FR, Dhar H.L. Antistress activity of Ocimum sanctum (Linn) (1987) Indian Drugs, 25 (5), pp. 172-175; Sanyal, A.K., Mitra, P.K., Goel, R.K., A modified method to estimate dissolved mucosubstances in gastric juice (1983) Indian J Exp Biol, 21, pp. 78-80; Freston, J.W., Overview of medicinal therapy of peptic ulcer disease (1990) Gastroenterol Clin North Am, 19, pp. 121-140; Robert, A., Current history of cytoprotection (1981) Gastroenterology, 21, pp. 78-80; Marini-Bettolo, G.B., Present aspects of the use of medicinal plants in traditional medicine (1980) J Ethnopharmacol, 2, pp. 5-7; Sen, P., Maiti, P.C., Puri, S., Ray, A., Audulov, N.A., Valdman, A.V., Mechanism of antistress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals (1992) Indian J Exp Biol, 30 (7), pp. 592-596. , Jul;; Brijmohan Sharma, T., Shivaraj Gouda, N., Venkat Rao, M., Shalam, SM Shantakumar, M.Laxmi Narasu A study on adaptogenic activity of stem extracts Of Tinospora malabarica (lamk) (2007) Pharmacologyonline, 1, pp. 349-358; Khandelwal KR. Practical pharmacognosy techniques and experiment.2nd edition Pune: Nirali prakashan 2000; 149-56; Gerhard Vogel, H., (2002) Drug Discovery and Evaluation, p. 867. , 2nd ed. New York. Springer-Verlag Berlin Heidelberg; Kulkarni, S.K., (1999) Handbook of Experimental Pharmacology, pp. 148-150. , 3rd ed. New Delhi Vallabh Prakashan;; Alder, R., (1984) Breakdown in Human Adptation to stress, p. 653. , Boston: Martinus Ninjihoff;; Goel, R.K., Bhattachariya, S.K., Gastro duodenal mucosal defense and mucosal protective agents (1991) Indian J Expl Biol, 29, pp. 701-714

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AB - The objective of the study was to investigate anti ulcer activity of petroleum ether, alcohol and aqueous extracts of stem of Tinospora malabarica (Lamk.). All the three extracts were subjected to preliminary phytochemical investigation and also for acute oral toxicity study. The preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates and amino acids in aqueous extract, flavonoids, alkaloids and carbohydrates in alcoholic extract, while petroleum ether extract contains only steroids. Aqueous and alcohol extracts found to be non toxic upto a dose of 5000 mg/kg while petroleum ether extract was safe up to a dose of 2000 mg/kg after single dose administration of the extract. Present study showed that, there was significant reduction in the ulcer index with aqueous and alcoholic extract and with that of petroleum ether it was less significant, also their was a considerable reduction in the free as well as the total acidity in pylorus ligated rats. In case of stress induced ulcers there was a significant reduction in ulcer index wit all the three extracts and percentage protection of aqueous extract was nearly equivalent with that of standard.

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Khayum MA, Nandakumar K, Gouda TS, Khalid SM, Venkat Rao N, Kumar SMS. Antiulcer activity of stem extracts of Tinospora malabarica (Lamk.). Pharmacologyonline. 2009;1:885-890.