Anxiogenic effect of lansoprazole in wistar rats

Lalit Mohan, Smita Shenoy, Anand Ramani, Saravanan, Shivakumar

Research output: Contribution to journalArticle

Abstract

Lansoprazole, a proton pump inhibitor, increases plasma levels of substance P. Substance P is known to play a role in anxiety. The objective of the study was to evaluate whether lansoprazole can cause anxiety in rats. Elevated plus maze and Open field test were used to assess anxiogenic activity. Four groups of rats were treated orally with gum acacia 10 ml/kg, lansoprazole 1 mg/kg, 2 mg/kg and 3 mg/kg doses respectively. The drugs were administered once daily for ten days. The time spent, number of entries, rears in the arms of the elevated plus maze and central and peripheral squares in the open field test were observed. In the elevated plus maze, the time spent by rats treated with lansoprazole (1, 2 and 3 mg/kg) was reduced in the open arm but increased in the closed arm as compared to control. The number of rearings in the closed arm in the lansoprazole treated rats was decreased as compared to control. In the open field, the time spent by rats treated with lansoprazole (2 mg/kg) was decreased in the centre but increased in the periphery as compared to control. The number of rearings in the periphery in rats treated with lansoprazole (2 mg/kg) was decreased as compared to control. Lansoprazole was found to induce anxiety in rats.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume7
Issue number1
Publication statusPublished - 01-03-2011

Fingerprint

Lansoprazole
Wistar Rats
Anxiety
Substance P
Gum Arabic
Proton Pump Inhibitors

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Mohan, Lalit ; Shenoy, Smita ; Ramani, Anand ; Saravanan ; Shivakumar. / Anxiogenic effect of lansoprazole in wistar rats. In: International Journal of Pharmaceutical Sciences Review and Research. 2011 ; Vol. 7, No. 1. pp. 86-88.
@article{65044684f6434c61bcdc8a3bbef4bc3d,
title = "Anxiogenic effect of lansoprazole in wistar rats",
abstract = "Lansoprazole, a proton pump inhibitor, increases plasma levels of substance P. Substance P is known to play a role in anxiety. The objective of the study was to evaluate whether lansoprazole can cause anxiety in rats. Elevated plus maze and Open field test were used to assess anxiogenic activity. Four groups of rats were treated orally with gum acacia 10 ml/kg, lansoprazole 1 mg/kg, 2 mg/kg and 3 mg/kg doses respectively. The drugs were administered once daily for ten days. The time spent, number of entries, rears in the arms of the elevated plus maze and central and peripheral squares in the open field test were observed. In the elevated plus maze, the time spent by rats treated with lansoprazole (1, 2 and 3 mg/kg) was reduced in the open arm but increased in the closed arm as compared to control. The number of rearings in the closed arm in the lansoprazole treated rats was decreased as compared to control. In the open field, the time spent by rats treated with lansoprazole (2 mg/kg) was decreased in the centre but increased in the periphery as compared to control. The number of rearings in the periphery in rats treated with lansoprazole (2 mg/kg) was decreased as compared to control. Lansoprazole was found to induce anxiety in rats.",
author = "Lalit Mohan and Smita Shenoy and Anand Ramani and Saravanan and Shivakumar",
year = "2011",
month = "3",
day = "1",
language = "English",
volume = "7",
pages = "86--88",
journal = "International Journal of Pharmaceutical Sciences Review and Research",
issn = "0976-044X",
publisher = "Global Research Online",
number = "1",

}

Anxiogenic effect of lansoprazole in wistar rats. / Mohan, Lalit; Shenoy, Smita; Ramani, Anand; Saravanan; Shivakumar.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 7, No. 1, 01.03.2011, p. 86-88.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anxiogenic effect of lansoprazole in wistar rats

AU - Mohan, Lalit

AU - Shenoy, Smita

AU - Ramani, Anand

AU - Saravanan,

AU - Shivakumar,

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Lansoprazole, a proton pump inhibitor, increases plasma levels of substance P. Substance P is known to play a role in anxiety. The objective of the study was to evaluate whether lansoprazole can cause anxiety in rats. Elevated plus maze and Open field test were used to assess anxiogenic activity. Four groups of rats were treated orally with gum acacia 10 ml/kg, lansoprazole 1 mg/kg, 2 mg/kg and 3 mg/kg doses respectively. The drugs were administered once daily for ten days. The time spent, number of entries, rears in the arms of the elevated plus maze and central and peripheral squares in the open field test were observed. In the elevated plus maze, the time spent by rats treated with lansoprazole (1, 2 and 3 mg/kg) was reduced in the open arm but increased in the closed arm as compared to control. The number of rearings in the closed arm in the lansoprazole treated rats was decreased as compared to control. In the open field, the time spent by rats treated with lansoprazole (2 mg/kg) was decreased in the centre but increased in the periphery as compared to control. The number of rearings in the periphery in rats treated with lansoprazole (2 mg/kg) was decreased as compared to control. Lansoprazole was found to induce anxiety in rats.

AB - Lansoprazole, a proton pump inhibitor, increases plasma levels of substance P. Substance P is known to play a role in anxiety. The objective of the study was to evaluate whether lansoprazole can cause anxiety in rats. Elevated plus maze and Open field test were used to assess anxiogenic activity. Four groups of rats were treated orally with gum acacia 10 ml/kg, lansoprazole 1 mg/kg, 2 mg/kg and 3 mg/kg doses respectively. The drugs were administered once daily for ten days. The time spent, number of entries, rears in the arms of the elevated plus maze and central and peripheral squares in the open field test were observed. In the elevated plus maze, the time spent by rats treated with lansoprazole (1, 2 and 3 mg/kg) was reduced in the open arm but increased in the closed arm as compared to control. The number of rearings in the closed arm in the lansoprazole treated rats was decreased as compared to control. In the open field, the time spent by rats treated with lansoprazole (2 mg/kg) was decreased in the centre but increased in the periphery as compared to control. The number of rearings in the periphery in rats treated with lansoprazole (2 mg/kg) was decreased as compared to control. Lansoprazole was found to induce anxiety in rats.

UR - http://www.scopus.com/inward/record.url?scp=80052673846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052673846&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 86

EP - 88

JO - International Journal of Pharmaceutical Sciences Review and Research

JF - International Journal of Pharmaceutical Sciences Review and Research

SN - 0976-044X

IS - 1

ER -