Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice

Shailesh Malaviya, K. Nandakumar, J. D. Vaghasiya, Y. S. Bhalodiya, N. P. Jivani, N. Sheth, R. A. Manek, S. P. Chauhan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study was designed to investigate anti anxiety effects of alcoholic and aqueous root extracts of Cardiospermum halicacabum in mice. Mice were treated with the alcoholic or aqueous extract (100 or 300 mg/kg p.o.) 1 hr before subjecting the animals to various anxiety models. Anti anxiety activity was evaluated using elevated plus maze (EPM), lightdark model (LDM) and open field test (OFT). In EPM, treatment with alcoholic and aqueous extracts increased the time spent in open arm and total locomotion time. In light dark model treatment with these extracts showed increase in time spent in light compartment and in Open field test treatment with these extracts increased the time spent in central compartment. These results suggest that alcoholic and aqueous extracts of Cardiospermum halicacabum possess anti anxiety activity.

Original languageEnglish
JournalInternet Journal of Pharmacology
Volume7
Issue number1
Publication statusPublished - 01-12-2009

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Sapindaceae
Anti-Anxiety Agents
Anxiety
Light
Locomotion

All Science Journal Classification (ASJC) codes

  • Pharmacology

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Malaviya, S., Nandakumar, K., Vaghasiya, J. D., Bhalodiya, Y. S., Jivani, N. P., Sheth, N., ... Chauhan, S. P. (2009). Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice. Internet Journal of Pharmacology, 7(1).
Malaviya, Shailesh ; Nandakumar, K. ; Vaghasiya, J. D. ; Bhalodiya, Y. S. ; Jivani, N. P. ; Sheth, N. ; Manek, R. A. ; Chauhan, S. P. / Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice. In: Internet Journal of Pharmacology. 2009 ; Vol. 7, No. 1.
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Malaviya, S, Nandakumar, K, Vaghasiya, JD, Bhalodiya, YS, Jivani, NP, Sheth, N, Manek, RA & Chauhan, SP 2009, 'Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice', Internet Journal of Pharmacology, vol. 7, no. 1.

Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice. / Malaviya, Shailesh; Nandakumar, K.; Vaghasiya, J. D.; Bhalodiya, Y. S.; Jivani, N. P.; Sheth, N.; Manek, R. A.; Chauhan, S. P.

In: Internet Journal of Pharmacology, Vol. 7, No. 1, 01.12.2009.

Research output: Contribution to journalArticle

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Malaviya S, Nandakumar K, Vaghasiya JD, Bhalodiya YS, Jivani NP, Sheth N et al. Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice. Internet Journal of Pharmacology. 2009 Dec 1;7(1).