Anxiolytic and anticonvulsant activity of aqueous extract of stem bark of Erythrina variegata in rodents

G. Pitchaiah, G.L. Viswanatha, R. Srinath, K. Nandakumar, D. Dayabaran, E.J. Florance

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Erythrina variegata and some other species of genus Erythrina are known to act on central nervous system. In India, Erythrina variegata is the species generally used by the traditional practioners of south India for the treatment of mental illness. The anxiolytic effect of aqueous extract (100, 200 and 400 mg/kg) was evaluated by using elevated plus-maze(EPM) model, light-dark transition (LDT) model and open field test (OFT), while Pentylene tetrazole (PTZ), Maximal electroshock (MES) induced convulsions models were used to assess anticonvulsant activity in male swiss albino mice. Pretreatment with aqueous extract and estimation of GABA in rat brain tissues also performed to study the effect of aqueous extract (100, 200 mg/kg) on GABA levels of brain. Aqueous extract showed significant anxiolytic and anticonvulsant activity and also showed significant modulation of GABA levels in cerebellum and also in whole brain other than cerebellum.
Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalInternational Journal of PharmTech Research
Issue number1
Publication statusPublished - 2010


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