Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats

A poly herbal formulation in rats

K. Vijayanarayana, Padma G.M. Rao, Nimmy Chacko, G. S. Kishore, N. Udupa

Research output: Contribution to journalArticle

Abstract

Geyenaphro' a polyherbal formulation, used in the treatment of sexual inertia, premature ejaculation and erectile dysfunction. The present study was aimed at investigating the aphrodisiac effect of 'Geyenaphro' in male and female albino rats in comparison with L-dihydroxyphenylalanine (L-dopa). 2-3 months old sexually inactive male and female rats were used for the study. In male rats, latency for mount, intromission, ejaculation and number of mounts, intromission and ejaculation and in female rats, number of lordosis and rejection were observed as parameters of assessment of aphrodisiac activity. 'Geyenaphro' significantly enhanced sexual activity in both male and female rats, both in single dose (100 mg/kg, orally) and chronic dose study (100 mg/kg /day orally for 28 days). 'Geyenaphro' was found to be superior to (L-Dopa) in male rats and equipotent in female rats.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalPharmacologyonline
Volume1
Publication statusPublished - 2010

Fingerprint

Aphrodisiacs
Ejaculation
Premature Ejaculation
Lordosis
Dihydroxyphenylalanine
Levodopa
Erectile Dysfunction
Sexual Behavior

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

@article{4fb8fb66471e47ddb657650b5e660a38,
title = "Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats: A poly herbal formulation in rats",
abstract = "Geyenaphro' a polyherbal formulation, used in the treatment of sexual inertia, premature ejaculation and erectile dysfunction. The present study was aimed at investigating the aphrodisiac effect of 'Geyenaphro' in male and female albino rats in comparison with L-dihydroxyphenylalanine (L-dopa). 2-3 months old sexually inactive male and female rats were used for the study. In male rats, latency for mount, intromission, ejaculation and number of mounts, intromission and ejaculation and in female rats, number of lordosis and rejection were observed as parameters of assessment of aphrodisiac activity. 'Geyenaphro' significantly enhanced sexual activity in both male and female rats, both in single dose (100 mg/kg, orally) and chronic dose study (100 mg/kg /day orally for 28 days). 'Geyenaphro' was found to be superior to (L-Dopa) in male rats and equipotent in female rats.",
author = "K. Vijayanarayana and Rao, {Padma G.M.} and Nimmy Chacko and Kishore, {G. S.} and N. Udupa",
note = "Export Date: 10 November 2017 Correspondence Address: Vijayanarayana, K.; Dept of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal-576104 Karnataka State, India; email: vinpharmacol@hotmail.com Chemicals/CAS: carbidopa plus levodopa, 57308-51-7 Tradenames: sinemet Manufacturers: Geyenayurvedics, India References: Nadkarni, A.K., (1976) Indian Materia Medica, 1, pp. 411-1294. , Bombay: Popular Prakashan Pvt Ltd; Ananth Kumar, K.V., Srinivasan, K.K., Rao, G., Aphrodisiac activity of the seed of Mucuna pruriens (1993) Indian Drugs, 31 (7), pp. 321-327; Vijayanarayana, K., Rashmi, S.R., Chandrashekhar, K.S., Subrahmanyam, E.V.S., Evaluation of estrogenic activity of Curculigo orchioides (2007) Journal of Ethnopharmacology, 114 (2), pp. 241-245; Burses, J., Buresova, O., Huston, J.P., (1983) Techniques and Basic Experiments For the Study of Brain and Behaviour, pp. 117-121. , New York: Elsevier Science Publishers; Biggers, J.D., Claringbold, P.J., Ovariectomisation (1954) Aust J Expt Biol Med Sci, 32, pp. 33-34; Venkatraman, B.V., Joseph, T., Effect of L-Dopa on Copulatory Behaviour in Rats (1979) Ind J Pharmac, 11 (2), pp. 119-125; Neil, D., Vogel, G., Diminished sexual activity in a new animal model of endogenous depression (1990) Neurosci Biobehav Rev, 14, pp. 73-76; Krishna Kumar, P.R., Vaidya, D.S.A., Selected Medicinal Plants of India, , Bombay: CHEMEXCIL, 1992119-356",
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Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats : A poly herbal formulation in rats. / Vijayanarayana, K.; Rao, Padma G.M.; Chacko, Nimmy; Kishore, G. S.; Udupa, N.

In: Pharmacologyonline, Vol. 1, 2010, p. 607-613.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats

T2 - A poly herbal formulation in rats

AU - Vijayanarayana, K.

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AU - Kishore, G. S.

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N1 - Export Date: 10 November 2017 Correspondence Address: Vijayanarayana, K.; Dept of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal-576104 Karnataka State, India; email: vinpharmacol@hotmail.com Chemicals/CAS: carbidopa plus levodopa, 57308-51-7 Tradenames: sinemet Manufacturers: Geyenayurvedics, India References: Nadkarni, A.K., (1976) Indian Materia Medica, 1, pp. 411-1294. , Bombay: Popular Prakashan Pvt Ltd; Ananth Kumar, K.V., Srinivasan, K.K., Rao, G., Aphrodisiac activity of the seed of Mucuna pruriens (1993) Indian Drugs, 31 (7), pp. 321-327; Vijayanarayana, K., Rashmi, S.R., Chandrashekhar, K.S., Subrahmanyam, E.V.S., Evaluation of estrogenic activity of Curculigo orchioides (2007) Journal of Ethnopharmacology, 114 (2), pp. 241-245; Burses, J., Buresova, O., Huston, J.P., (1983) Techniques and Basic Experiments For the Study of Brain and Behaviour, pp. 117-121. , New York: Elsevier Science Publishers; Biggers, J.D., Claringbold, P.J., Ovariectomisation (1954) Aust J Expt Biol Med Sci, 32, pp. 33-34; Venkatraman, B.V., Joseph, T., Effect of L-Dopa on Copulatory Behaviour in Rats (1979) Ind J Pharmac, 11 (2), pp. 119-125; Neil, D., Vogel, G., Diminished sexual activity in a new animal model of endogenous depression (1990) Neurosci Biobehav Rev, 14, pp. 73-76; Krishna Kumar, P.R., Vaidya, D.S.A., Selected Medicinal Plants of India, , Bombay: CHEMEXCIL, 1992119-356

PY - 2010

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