Application of hot melt extrusion for the solubility enhancement of a BCS class II drug

Ashay Manisha Shailendra Kumar, Girish Pai Kulyadi, Srinivas Mutalik, Vijay Induvadan Kulkarni, Vamshi Krishna Tippavajhala

Research output: Contribution to journalArticle

Abstract

Solubility enhancement of poorly soluble drugs for improved oral absorption has become a challenging task for the scientists in the development of pharmaceuticals. The main goal of this study is to investigate the effect of the hydrophilic polymers on the poorly water soluble drug to enhance its solubility through the technique of hot-melt extrusion. The drug selected for this study is paracetamol and the hydrophilic polymers selected for this study are polyox, carbopol 980p, and PEG 6000. The drug and the polymer at a ratio of 1:2 was processed through STEERLife twin screw extruder. The obtained solid dispersion was subjected to the saturation solubility study. Among the selected polymers, paracetamol with polyox polymer has shown enhanced solubility followed by PEG 6000 and carbopol 980p.

Original languageEnglish
Pages (from-to)3751-3754
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Volume12
Issue number8
DOIs
Publication statusPublished - 08-2019

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Solubility
Polymers
Pharmaceutical Preparations
Acetaminophen
Water
Polyethylene Glycol 6000
carboxypolymethylene

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

Cite this

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abstract = "Solubility enhancement of poorly soluble drugs for improved oral absorption has become a challenging task for the scientists in the development of pharmaceuticals. The main goal of this study is to investigate the effect of the hydrophilic polymers on the poorly water soluble drug to enhance its solubility through the technique of hot-melt extrusion. The drug selected for this study is paracetamol and the hydrophilic polymers selected for this study are polyox, carbopol 980p, and PEG 6000. The drug and the polymer at a ratio of 1:2 was processed through STEERLife twin screw extruder. The obtained solid dispersion was subjected to the saturation solubility study. Among the selected polymers, paracetamol with polyox polymer has shown enhanced solubility followed by PEG 6000 and carbopol 980p.",
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Application of hot melt extrusion for the solubility enhancement of a BCS class II drug. / Kumar, Ashay Manisha Shailendra; Kulyadi, Girish Pai; Mutalik, Srinivas; Kulkarni, Vijay Induvadan; Tippavajhala, Vamshi Krishna.

In: Research Journal of Pharmacy and Technology, Vol. 12, No. 8, 08.2019, p. 3751-3754.

Research output: Contribution to journalArticle

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