Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

Bhushan B. Borase, Himanshu M. Godbole, Girij P. Singh, Pritesh R. Upadhyay, Anurag Trivedi, Varadaraj Bhat, Gautham G. Shenoy

Research output: Contribution to journalArticle

Abstract

A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.

Original languageEnglish
JournalSynthetic Communications
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Amides
Blood pressure
Pharmaceutical Preparations
quinapril

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Borase, Bhushan B. ; Godbole, Himanshu M. ; Singh, Girij P. ; Upadhyay, Pritesh R. ; Trivedi, Anurag ; Bhat, Varadaraj ; Shenoy, Gautham G. / Application of Ugi three component reaction for the synthesis of quinapril hydrochloride. In: Synthetic Communications. 2019.
@article{fd5e24f3111c4b5f81b59346759e1e85,
title = "Application of Ugi three component reaction for the synthesis of quinapril hydrochloride",
abstract = "A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.",
author = "Borase, {Bhushan B.} and Godbole, {Himanshu M.} and Singh, {Girij P.} and Upadhyay, {Pritesh R.} and Anurag Trivedi and Varadaraj Bhat and Shenoy, {Gautham G.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/00397911.2019.1682168",
language = "English",
journal = "Synthetic Communications",
issn = "0039-7911",
publisher = "Taylor and Francis Ltd.",

}

Application of Ugi three component reaction for the synthesis of quinapril hydrochloride. / Borase, Bhushan B.; Godbole, Himanshu M.; Singh, Girij P.; Upadhyay, Pritesh R.; Trivedi, Anurag; Bhat, Varadaraj; Shenoy, Gautham G.

In: Synthetic Communications, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

AU - Borase, Bhushan B.

AU - Godbole, Himanshu M.

AU - Singh, Girij P.

AU - Upadhyay, Pritesh R.

AU - Trivedi, Anurag

AU - Bhat, Varadaraj

AU - Shenoy, Gautham G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.

AB - A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.

UR - http://www.scopus.com/inward/record.url?scp=85075007995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075007995&partnerID=8YFLogxK

U2 - 10.1080/00397911.2019.1682168

DO - 10.1080/00397911.2019.1682168

M3 - Article

AN - SCOPUS:85075007995

JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

ER -