Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

Bhushan B. Borase, Himanshu M. Godbole, Girij P. Singh, Pritesh R. Upadhyay, Anurag Trivedi, Varadaraj Bhat, Gautham G. Shenoy

Research output: Contribution to journalArticle

Abstract

A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction.

Original languageEnglish
JournalSynthetic Communications
DOIs
Publication statusAccepted/In press - 01-01-2019

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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