Are patients with limb and head tremor a clinically distinct subtype of essential tremor?

Abhishek Lenka, Ketaki Swapnil Bhalsing, Ketan Ramakant Jhunjhunwala, Vijay Chandran, Pramod Kumar Pal

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

BACKGROUND: Essential tremor (ET) is the most common tremor disorder in adults. In addition to upper limbs, the tremor in ET may also involve head, jaw, voice, tongue, and trunk. Though head tremor (HT) is commonly present in patients with ET, large comparative studies of ET patients with HT (HT+) and without HT (HT-) are few.

METHODS: To determine whether ET with HT is a distinct clinical subtype by comparing ET patients with and without HT, a chart review of 234 consecutive patients with ET attending the neurology clinics of the National Institute of Mental Health and Neurosciences, India, was done. A movement disorder specialist confirmed the diagnosis of ET in all patients using the National Institutes of Health collaborative genetic criteria.

RESULTS: HT was present in 44.4% of the patients. Comparison between HT+ and HT- showed that the HT+ group patients: (1) were older, (2) had later onset of tremor, (3) had unimodal distribution of age at onset with a single peak in the fifth decade, (4) had more frequent voice tremor, and (5) were more likely to have mild cervical dystonia. HT was part of presenting symptoms in nearly two thirds of the ET patients and in the rest it was detected during clinical examination.

CONCLUSIONS: Several demographic and clinical variables suggest that ET patients with HT have a distinct clinical phenotype.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Volume42
Issue number3
DOIs
Publication statusPublished - 01-05-2015

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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