Arterial resistance in late first trimester as a predictor of subsequent pregnancy-related hypertension

Pralhad Kushtagi, Anoosha Emani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: This study aimed to examine the association between indicators of arterial resistance occurring late in the first trimester and the subsequent development of pregnancy-related hypertension. Methods: This study took place between May 2014 and August 2015 and included 329 consecutive women with singleton pregnancies attending the antenatal clinics of a medical college in Karnataka, India, during this period. Pulse pressure (PP) and uterine artery Doppler parameters were recorded between 11–14 gestational weeks. Consequently, women were followed-up until after delivery for subsequent hypertension. Results: Hypertension occurred more frequently if PP was high (17.6% versus 14.4% of pregnancies without high PP; P = 0.713), if a diastolic notch (DN) was present (15.1% versus 12.8% of pregnancies with an absent DN; P = 0.612) and if the resistive index (RI) was raised (22.2% versus 14.3% of pregnancies without raised RI; P = 0.366). A raised pulsatility index (PI) was significantly associated with hypertension (P = 0.013). The risk of hypertension was approximately seven-fold higher if two or more arterial resistance indicators were used, except with a present DN plus a raised RI or a present DN plus high PP. All arterial resistance indicators showed negative predictability (>85.6%) and good specificity (≥95.0%), except for the presence of a DN. A population-specific cut-off PI value of 1.72 had high negative predictability (92.8%) and good sensitivity (70.8%) and specificity (65.1%). Conclusion: Raised PI in the late first trimester was a significant predictor of hypertension later in pregnancy. A combination of arterial resistance indicators may enhance prediction of subsequent hypertension.

Original languageEnglish
Pages (from-to)e451-e457
JournalSultan Qaboos University Medical Journal
Volume16
Issue number4
DOIs
Publication statusPublished - 01-11-2016

Fingerprint

First Pregnancy Trimester
Hypertension
Pregnancy
Blood Pressure
Uterine Artery
India
Sensitivity and Specificity
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{93914ba73e4149aeaebd92f83ca677c2,
title = "Arterial resistance in late first trimester as a predictor of subsequent pregnancy-related hypertension",
abstract = "Objectives: This study aimed to examine the association between indicators of arterial resistance occurring late in the first trimester and the subsequent development of pregnancy-related hypertension. Methods: This study took place between May 2014 and August 2015 and included 329 consecutive women with singleton pregnancies attending the antenatal clinics of a medical college in Karnataka, India, during this period. Pulse pressure (PP) and uterine artery Doppler parameters were recorded between 11–14 gestational weeks. Consequently, women were followed-up until after delivery for subsequent hypertension. Results: Hypertension occurred more frequently if PP was high (17.6{\%} versus 14.4{\%} of pregnancies without high PP; P = 0.713), if a diastolic notch (DN) was present (15.1{\%} versus 12.8{\%} of pregnancies with an absent DN; P = 0.612) and if the resistive index (RI) was raised (22.2{\%} versus 14.3{\%} of pregnancies without raised RI; P = 0.366). A raised pulsatility index (PI) was significantly associated with hypertension (P = 0.013). The risk of hypertension was approximately seven-fold higher if two or more arterial resistance indicators were used, except with a present DN plus a raised RI or a present DN plus high PP. All arterial resistance indicators showed negative predictability (>85.6{\%}) and good specificity (≥95.0{\%}), except for the presence of a DN. A population-specific cut-off PI value of 1.72 had high negative predictability (92.8{\%}) and good sensitivity (70.8{\%}) and specificity (65.1{\%}). Conclusion: Raised PI in the late first trimester was a significant predictor of hypertension later in pregnancy. A combination of arterial resistance indicators may enhance prediction of subsequent hypertension.",
author = "Pralhad Kushtagi and Anoosha Emani",
year = "2016",
month = "11",
day = "1",
doi = "10.18295/squmj.2016.16.04.008",
language = "English",
volume = "16",
pages = "e451--e457",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "4",

}

Arterial resistance in late first trimester as a predictor of subsequent pregnancy-related hypertension. / Kushtagi, Pralhad; Emani, Anoosha.

In: Sultan Qaboos University Medical Journal, Vol. 16, No. 4, 01.11.2016, p. e451-e457.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arterial resistance in late first trimester as a predictor of subsequent pregnancy-related hypertension

AU - Kushtagi, Pralhad

AU - Emani, Anoosha

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objectives: This study aimed to examine the association between indicators of arterial resistance occurring late in the first trimester and the subsequent development of pregnancy-related hypertension. Methods: This study took place between May 2014 and August 2015 and included 329 consecutive women with singleton pregnancies attending the antenatal clinics of a medical college in Karnataka, India, during this period. Pulse pressure (PP) and uterine artery Doppler parameters were recorded between 11–14 gestational weeks. Consequently, women were followed-up until after delivery for subsequent hypertension. Results: Hypertension occurred more frequently if PP was high (17.6% versus 14.4% of pregnancies without high PP; P = 0.713), if a diastolic notch (DN) was present (15.1% versus 12.8% of pregnancies with an absent DN; P = 0.612) and if the resistive index (RI) was raised (22.2% versus 14.3% of pregnancies without raised RI; P = 0.366). A raised pulsatility index (PI) was significantly associated with hypertension (P = 0.013). The risk of hypertension was approximately seven-fold higher if two or more arterial resistance indicators were used, except with a present DN plus a raised RI or a present DN plus high PP. All arterial resistance indicators showed negative predictability (>85.6%) and good specificity (≥95.0%), except for the presence of a DN. A population-specific cut-off PI value of 1.72 had high negative predictability (92.8%) and good sensitivity (70.8%) and specificity (65.1%). Conclusion: Raised PI in the late first trimester was a significant predictor of hypertension later in pregnancy. A combination of arterial resistance indicators may enhance prediction of subsequent hypertension.

AB - Objectives: This study aimed to examine the association between indicators of arterial resistance occurring late in the first trimester and the subsequent development of pregnancy-related hypertension. Methods: This study took place between May 2014 and August 2015 and included 329 consecutive women with singleton pregnancies attending the antenatal clinics of a medical college in Karnataka, India, during this period. Pulse pressure (PP) and uterine artery Doppler parameters were recorded between 11–14 gestational weeks. Consequently, women were followed-up until after delivery for subsequent hypertension. Results: Hypertension occurred more frequently if PP was high (17.6% versus 14.4% of pregnancies without high PP; P = 0.713), if a diastolic notch (DN) was present (15.1% versus 12.8% of pregnancies with an absent DN; P = 0.612) and if the resistive index (RI) was raised (22.2% versus 14.3% of pregnancies without raised RI; P = 0.366). A raised pulsatility index (PI) was significantly associated with hypertension (P = 0.013). The risk of hypertension was approximately seven-fold higher if two or more arterial resistance indicators were used, except with a present DN plus a raised RI or a present DN plus high PP. All arterial resistance indicators showed negative predictability (>85.6%) and good specificity (≥95.0%), except for the presence of a DN. A population-specific cut-off PI value of 1.72 had high negative predictability (92.8%) and good sensitivity (70.8%) and specificity (65.1%). Conclusion: Raised PI in the late first trimester was a significant predictor of hypertension later in pregnancy. A combination of arterial resistance indicators may enhance prediction of subsequent hypertension.

UR - http://www.scopus.com/inward/record.url?scp=85000956419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000956419&partnerID=8YFLogxK

U2 - 10.18295/squmj.2016.16.04.008

DO - 10.18295/squmj.2016.16.04.008

M3 - Article

VL - 16

SP - e451-e457

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 4

ER -