Aspirin resistance

K. A. Ashwin, K. L. Bairy, Sudha Vidyasagar, Muralidhar Verma, C. K. Prashanth, A. Sachidananda

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Aspirin reduces the odds of serious atherothrombotic vascular events and death in a broad category of high risk patients by about one quarter. The term 'aspirin resistance' has been used to describe not only an absence of the expected pharmacologic effects of aspirin on platelets but also poor clinical outcomes, such as recurrent vascular events, in patients treated with aspirin. Various factors such as genetic, nonadherence, variable response to different doses, co-morbid conditions and drug interactions are responsible for aspirin resistance. Many methods, with their limitations, are available to measure the effects on platelets. Despite treatment failures, aspirin remains the single most cost-effective drug for the secondary prevention of atherothrombotic disease. To optimize its clinical effectiveness, clinicians should be aware of the potential causes of aspirin treatment failure, prescribe aspirin in appropriate doses, and encourage patients to take aspirin, stop smoking, and avoid regular use of NSAIDs.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalIndian Journal of Physiology and Pharmacology
Volume51
Issue number2
Publication statusPublished - 01-04-2007

Fingerprint

Aspirin
Treatment Failure
Blood Vessels
Blood Platelets
Drug Costs
Non-Steroidal Anti-Inflammatory Agents
Secondary Prevention
Drug Interactions
Smoking

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Ashwin, K. A., Bairy, K. L., Vidyasagar, S., Verma, M., Prashanth, C. K., & Sachidananda, A. (2007). Aspirin resistance. Indian Journal of Physiology and Pharmacology, 51(2), 109-117.
Ashwin, K. A. ; Bairy, K. L. ; Vidyasagar, Sudha ; Verma, Muralidhar ; Prashanth, C. K. ; Sachidananda, A. / Aspirin resistance. In: Indian Journal of Physiology and Pharmacology. 2007 ; Vol. 51, No. 2. pp. 109-117.
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Ashwin, KA, Bairy, KL, Vidyasagar, S, Verma, M, Prashanth, CK & Sachidananda, A 2007, 'Aspirin resistance', Indian Journal of Physiology and Pharmacology, vol. 51, no. 2, pp. 109-117.

Aspirin resistance. / Ashwin, K. A.; Bairy, K. L.; Vidyasagar, Sudha; Verma, Muralidhar; Prashanth, C. K.; Sachidananda, A.

In: Indian Journal of Physiology and Pharmacology, Vol. 51, No. 2, 01.04.2007, p. 109-117.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Aspirin resistance

AU - Ashwin, K. A.

AU - Bairy, K. L.

AU - Vidyasagar, Sudha

AU - Verma, Muralidhar

AU - Prashanth, C. K.

AU - Sachidananda, A.

PY - 2007/4/1

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N2 - Aspirin reduces the odds of serious atherothrombotic vascular events and death in a broad category of high risk patients by about one quarter. The term 'aspirin resistance' has been used to describe not only an absence of the expected pharmacologic effects of aspirin on platelets but also poor clinical outcomes, such as recurrent vascular events, in patients treated with aspirin. Various factors such as genetic, nonadherence, variable response to different doses, co-morbid conditions and drug interactions are responsible for aspirin resistance. Many methods, with their limitations, are available to measure the effects on platelets. Despite treatment failures, aspirin remains the single most cost-effective drug for the secondary prevention of atherothrombotic disease. To optimize its clinical effectiveness, clinicians should be aware of the potential causes of aspirin treatment failure, prescribe aspirin in appropriate doses, and encourage patients to take aspirin, stop smoking, and avoid regular use of NSAIDs.

AB - Aspirin reduces the odds of serious atherothrombotic vascular events and death in a broad category of high risk patients by about one quarter. The term 'aspirin resistance' has been used to describe not only an absence of the expected pharmacologic effects of aspirin on platelets but also poor clinical outcomes, such as recurrent vascular events, in patients treated with aspirin. Various factors such as genetic, nonadherence, variable response to different doses, co-morbid conditions and drug interactions are responsible for aspirin resistance. Many methods, with their limitations, are available to measure the effects on platelets. Despite treatment failures, aspirin remains the single most cost-effective drug for the secondary prevention of atherothrombotic disease. To optimize its clinical effectiveness, clinicians should be aware of the potential causes of aspirin treatment failure, prescribe aspirin in appropriate doses, and encourage patients to take aspirin, stop smoking, and avoid regular use of NSAIDs.

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Ashwin KA, Bairy KL, Vidyasagar S, Verma M, Prashanth CK, Sachidananda A. Aspirin resistance. Indian Journal of Physiology and Pharmacology. 2007 Apr 1;51(2):109-117.