Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee; Prabin Gyawali; Rajesh Kumar Thakur; Revathi P. Shenoy; Anjali Rao

doi:10.1016/S2222-1808(11)60067-4

Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee, Prabin Gyawali, Rajesh Kumar Thakur, Revathi P. Shenoy, Anjali Rao

Department of Biochemistry, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

Original language	English
Pages (from-to)	287-288
Number of pages	2
Journal	Asian Pacific Journal of Tropical Disease
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/S2222-1808(11)60067-4
Publication status	Published - 01-12-2011

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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Mukherjee, M., Gyawali, P., Thakur, R. K., Shenoy, R. P., & Rao, A. (2011). Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India. Asian Pacific Journal of Tropical Disease, 1(4), 287-288. https://doi.org/10.1016/S2222-1808(11)60067-4

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abstract = "Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.",

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Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India. / Mukherjee, Madhurima; Gyawali, Prabin; Thakur, Rajesh Kumar; Shenoy, Revathi P.; Rao, Anjali.

In: Asian Pacific Journal of Tropical Disease, Vol. 1, No. 4, 01.12.2011, p. 287-288.

Research output: Contribution to journal › Article

TY - JOUR

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AU - Mukherjee, Madhurima

AU - Gyawali, Prabin

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AU - Shenoy, Revathi P.

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