TY - JOUR
T1 - Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India
AU - Mukherjee, Madhurima
AU - Gyawali, Prabin
AU - Thakur, Rajesh Kumar
AU - Shenoy, Revathi P.
AU - Rao, Anjali
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
AB - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
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U2 - 10.1016/S2222-1808(11)60067-4
DO - 10.1016/S2222-1808(11)60067-4
M3 - Article
AN - SCOPUS:82455223703
VL - 1
SP - 287
EP - 288
JO - Asian Pacific Journal of Tropical Disease
JF - Asian Pacific Journal of Tropical Disease
SN - 2222-1808
IS - 4
ER -