Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee, Prabin Gyawali, Rajesh Kumar Thakur, Revathi P. Shenoy, Anjali Rao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalAsian Pacific Journal of Tropical Disease
Volume1
Issue number4
DOIs
Publication statusPublished - 01-12-2011

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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