Abstract
Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 287-288 |
| Number of pages | 2 |
| Journal | Asian Pacific Journal of Tropical Disease |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-12-2011 |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
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Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India. / Mukherjee, Madhurima; Gyawali, Prabin; Thakur, Rajesh Kumar; Shenoy, Revathi P.; Rao, Anjali.
In: Asian Pacific Journal of Tropical Disease, Vol. 1, No. 4, 01.12.2011, p. 287-288.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India
AU - Mukherjee, Madhurima
AU - Gyawali, Prabin
AU - Thakur, Rajesh Kumar
AU - Shenoy, Revathi P.
AU - Rao, Anjali
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
AB - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.
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U2 - 10.1016/S2222-1808(11)60067-4
DO - 10.1016/S2222-1808(11)60067-4
M3 - Article
VL - 1
SP - 287
EP - 288
JO - Asian Pacific Journal of Tropical Disease
JF - Asian Pacific Journal of Tropical Disease
SN - 2222-1808
IS - 4
ER -