Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India

Madhurima Mukherjee, Prabin Gyawali, Rajesh Kumar Thakur, Revathi P. Shenoy, Anjali Rao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalAsian Pacific Journal of Tropical Disease
Volume1
Issue number4
DOIs
Publication statusPublished - 01-12-2011

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Oral Lichen Planus
Cheek
India
Oxidative Stress
Mouth Mucosa
Free Radicals
DNA Damage
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India",
abstract = "Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.",
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Assessment of frequency of micronucleated exfoliated buccal cells in relation to oxidative stress in oral lichen planus in coastal Karnataka, India. / Mukherjee, Madhurima; Gyawali, Prabin; Thakur, Rajesh Kumar; Shenoy, Revathi P.; Rao, Anjali.

In: Asian Pacific Journal of Tropical Disease, Vol. 1, No. 4, 01.12.2011, p. 287-288.

Research output: Contribution to journalArticle

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AU - Mukherjee, Madhurima

AU - Gyawali, Prabin

AU - Thakur, Rajesh Kumar

AU - Shenoy, Revathi P.

AU - Rao, Anjali

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AB - Objective: To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods: The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects. Results: A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects. Conclusions: It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

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