Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study

Ashish Agarwal, Anupama Hegde, Charu Yadav, Afzal Ahmad, Poornima A. Manjrekar, Rukmini M. Srikantiah

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND AND AIM: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements.

MATERIALS AND METHODS: Based on FPG values, 80 subjects were grouped into prediabetes and healthy controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine sample.

RESULTS: Prediabetes group had significantly increased (p<0.05) mean anthropometric measurements and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI (r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-0.493)) while MA did not correlate with FPG and anthropometric measurements.

CONCLUSION: This study suggests that prediabetes is associated with central adiposity, inflammation and oxidative stress predisposing them to an increased risk for CVD.

Original languageEnglish
Pages (from-to)S123-S126
JournalDiabetes & metabolic syndrome
Volume10
Issue number2
DOIs
Publication statusPublished - 01-04-2016

Fingerprint

Prediabetic State
Oxidative Stress
Cross-Sectional Studies
Peroxidase
Inflammation
Interleukin-6
Fasting
Glucose
Cardiovascular Diseases
Urine
Waist-Hip Ratio
Adiposity
Waist Circumference
Serum
Body Mass Index
Obesity

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{8d3a6ff130dc4b338e19470c3c4548a8,
title = "Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study",
abstract = "BACKGROUND AND AIM: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements.MATERIALS AND METHODS: Based on FPG values, 80 subjects were grouped into prediabetes and healthy controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine sample.RESULTS: Prediabetes group had significantly increased (p<0.05) mean anthropometric measurements and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI (r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-0.493)) while MA did not correlate with FPG and anthropometric measurements.CONCLUSION: This study suggests that prediabetes is associated with central adiposity, inflammation and oxidative stress predisposing them to an increased risk for CVD.",
author = "Ashish Agarwal and Anupama Hegde and Charu Yadav and Afzal Ahmad and Manjrekar, {Poornima A.} and Srikantiah, {Rukmini M.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.dsx.2016.03.009",
language = "English",
volume = "10",
pages = "S123--S126",
journal = "Diabetes and Metabolic Syndrome: Clinical Research and Reviews",
issn = "1871-4021",
publisher = "Elsevier BV",
number = "2",

}

Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study. / Agarwal, Ashish; Hegde, Anupama; Yadav, Charu; Ahmad, Afzal; Manjrekar, Poornima A.; Srikantiah, Rukmini M.

In: Diabetes & metabolic syndrome, Vol. 10, No. 2, 01.04.2016, p. S123-S126.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study

AU - Agarwal, Ashish

AU - Hegde, Anupama

AU - Yadav, Charu

AU - Ahmad, Afzal

AU - Manjrekar, Poornima A.

AU - Srikantiah, Rukmini M.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND AND AIM: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements.MATERIALS AND METHODS: Based on FPG values, 80 subjects were grouped into prediabetes and healthy controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine sample.RESULTS: Prediabetes group had significantly increased (p<0.05) mean anthropometric measurements and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI (r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-0.493)) while MA did not correlate with FPG and anthropometric measurements.CONCLUSION: This study suggests that prediabetes is associated with central adiposity, inflammation and oxidative stress predisposing them to an increased risk for CVD.

AB - BACKGROUND AND AIM: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements.MATERIALS AND METHODS: Based on FPG values, 80 subjects were grouped into prediabetes and healthy controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine sample.RESULTS: Prediabetes group had significantly increased (p<0.05) mean anthropometric measurements and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI (r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-0.493)) while MA did not correlate with FPG and anthropometric measurements.CONCLUSION: This study suggests that prediabetes is associated with central adiposity, inflammation and oxidative stress predisposing them to an increased risk for CVD.

UR - http://www.scopus.com/inward/record.url?scp=85027946931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027946931&partnerID=8YFLogxK

U2 - 10.1016/j.dsx.2016.03.009

DO - 10.1016/j.dsx.2016.03.009

M3 - Article

VL - 10

SP - S123-S126

JO - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

JF - Diabetes and Metabolic Syndrome: Clinical Research and Reviews

SN - 1871-4021

IS - 2

ER -