Abstract
Epidemiological studies in children have proved that lead (Pb) exposure causes deficits in neural and cognitive functions. The present study assessed the oxidative stress on postnatal day 30, in the hippocampus, cerebellum and frontal cortex of rat pups exposed to Pb during specific periods of early brain development. Five groups of rat pups were investigated, and 0.2 % Pb acetate in drinking was the dosage used. (i) Gestation and lactation (GL) group (n = 9) of rat pups was exposed to Pb during gestation and lactation through their mother, (ii) gestation (G) group (n = 9) of rat pups was exposed to Pb during gestation only, (iii) lactation (L) group (n = 9) of rat pups was exposed to Pb during lactation only, (iv) pre-gestation (PG) group (n = 9) of rat pups was born to mothers who were exposed to Pb for 1 month before conception, and (v) normal control (NC) (n = 9) group of rats pups had no exposure to Pb during gestation and lactation period. From the present study, it is evident that Pb exposure during different periods of early brain development (GL, G, L and PG groups) causes oxidative stress and lactation period (postnatal period) of Pb exposure produces maximum oxidative stress.
| Original language | English |
|---|---|
| Pages (from-to) | 212-218 |
| Number of pages | 7 |
| Journal | Biological Trace Element Research |
| Volume | 164 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical
- Inorganic Chemistry
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Assessment of Oxidative Stress in Hippocampus, Cerebellum and Frontal Cortex in Rat Pups Exposed to Lead (Pb) During Specific Periods of Initial Brain Development. / Barkur, Rajashekar Rao; Bairy, Laxminarayana Kurady.
In: Biological Trace Element Research, Vol. 164, No. 2, 2015, p. 212-218.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessment of Oxidative Stress in Hippocampus, Cerebellum and Frontal Cortex in Rat Pups Exposed to Lead (Pb) During Specific Periods of Initial Brain Development
AU - Barkur, Rajashekar Rao
AU - Bairy, Laxminarayana Kurady
PY - 2015
Y1 - 2015
N2 - Epidemiological studies in children have proved that lead (Pb) exposure causes deficits in neural and cognitive functions. The present study assessed the oxidative stress on postnatal day 30, in the hippocampus, cerebellum and frontal cortex of rat pups exposed to Pb during specific periods of early brain development. Five groups of rat pups were investigated, and 0.2 % Pb acetate in drinking was the dosage used. (i) Gestation and lactation (GL) group (n = 9) of rat pups was exposed to Pb during gestation and lactation through their mother, (ii) gestation (G) group (n = 9) of rat pups was exposed to Pb during gestation only, (iii) lactation (L) group (n = 9) of rat pups was exposed to Pb during lactation only, (iv) pre-gestation (PG) group (n = 9) of rat pups was born to mothers who were exposed to Pb for 1 month before conception, and (v) normal control (NC) (n = 9) group of rats pups had no exposure to Pb during gestation and lactation period. From the present study, it is evident that Pb exposure during different periods of early brain development (GL, G, L and PG groups) causes oxidative stress and lactation period (postnatal period) of Pb exposure produces maximum oxidative stress.
AB - Epidemiological studies in children have proved that lead (Pb) exposure causes deficits in neural and cognitive functions. The present study assessed the oxidative stress on postnatal day 30, in the hippocampus, cerebellum and frontal cortex of rat pups exposed to Pb during specific periods of early brain development. Five groups of rat pups were investigated, and 0.2 % Pb acetate in drinking was the dosage used. (i) Gestation and lactation (GL) group (n = 9) of rat pups was exposed to Pb during gestation and lactation through their mother, (ii) gestation (G) group (n = 9) of rat pups was exposed to Pb during gestation only, (iii) lactation (L) group (n = 9) of rat pups was exposed to Pb during lactation only, (iv) pre-gestation (PG) group (n = 9) of rat pups was born to mothers who were exposed to Pb for 1 month before conception, and (v) normal control (NC) (n = 9) group of rats pups had no exposure to Pb during gestation and lactation period. From the present study, it is evident that Pb exposure during different periods of early brain development (GL, G, L and PG groups) causes oxidative stress and lactation period (postnatal period) of Pb exposure produces maximum oxidative stress.
UR - http://www.scopus.com/inward/record.url?scp=84924955681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924955681&partnerID=8YFLogxK
U2 - 10.1007/s12011-014-0221-3
DO - 10.1007/s12011-014-0221-3
M3 - Article
C2 - 25575663
AN - SCOPUS:84924955681
VL - 164
SP - 212
EP - 218
JO - Biological Trace Element Research
JF - Biological Trace Element Research
SN - 0163-4984
IS - 2
ER -