Abstract

Objective: To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1% delivered at term while 5.9% had preterm deliveries. Preterm deliveries were noted among 6.5% women with short stature, 13.3% with cervical length <2.5. cms and 5.2% among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9%) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.

Original languageEnglish
JournalClinical Epidemiology and Global Health
DOIs
Publication statusPublished - 2018

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Term Birth
Premature Birth
Oligohydramnios
Secondary Care
Estriol
Fetal Growth Retardation
Obstetrics
Pregnancy
Reproductive History
Prenatal Care
Incidence
Cervix Uteri
Anemia
Pregnant Women
Cohort Studies
Biomarkers
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

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title = "Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort",
abstract = "Objective: To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1{\%} delivered at term while 5.9{\%} had preterm deliveries. Preterm deliveries were noted among 6.5{\%} women with short stature, 13.3{\%} with cervical length <2.5. cms and 5.2{\%} among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9{\%}) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.",
author = "Rao, {Chythra R.} and Parvati Bhat and Vandana KE and Veena Kamath and Asha Kamath and Dinesh Nayak and Shenoy, {Revathi P.} and Bhat, {Shashikala K.}",
year = "2018",
doi = "10.1016/j.cegh.2017.07.001",
language = "English",
journal = "Clinical Epidemiology and Global Health",
issn = "2213-3984",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Assessment of risk factors and predictors for spontaneous pre-term birth in a South Indian antenatal cohort

AU - Rao, Chythra R.

AU - Bhat, Parvati

AU - KE, Vandana

AU - Kamath, Veena

AU - Kamath, Asha

AU - Nayak, Dinesh

AU - Shenoy, Revathi P.

AU - Bhat, Shashikala K.

PY - 2018

Y1 - 2018

N2 - Objective: To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1% delivered at term while 5.9% had preterm deliveries. Preterm deliveries were noted among 6.5% women with short stature, 13.3% with cervical length <2.5. cms and 5.2% among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9%) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.

AB - Objective: To assess incidence of spontaneous preterm births and determine biochemical and obstetric risk factors for spontaneous pre-term births in a cohort of antenatal women visiting a secondary care hospital. Methods: A prospective cohort study was designed to include 1420 pregnant women coming for antenatal care at a secondary care hospital. The cohort was followed throughout pregnancy and relevant history, obstetric and ultrasonographic examination and biochemical investigations was carried out in 2nd (20-24 weeks period of gestation) and 3rd trimester (28-32 weeks period of gestation). Outcome of delivery was noted for all the subjects. Results: A total of 1133 women were recruited. Among the 1071 respondents, 11 had abortions, 93.1% delivered at term while 5.9% had preterm deliveries. Preterm deliveries were noted among 6.5% women with short stature, 13.3% with cervical length <2.5. cms and 5.2% among women with anaemia. Statistically significant association was noted between Oligohydramnios, IUGR and preterm births. Salivary estriol was lower in women who had preterm births as compared to term births. Conclusions: The incidence of preterm births (5.9%) was low in the present cohort. Oligohydramnios and Intrauterine Growth Retardation (IUGR) were identified as significant risk factors for preterm births. Conventional risk factors like short cervix, short stature and biochemical inflammatory markers were not identified as predictors of prematurity. Lower levels of salivary estriol identified among women at risk of preterm births demonstrates the utility of the test as a non-invasive investigation for early identification of preterm births.

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U2 - 10.1016/j.cegh.2017.07.001

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JO - Clinical Epidemiology and Global Health

JF - Clinical Epidemiology and Global Health

SN - 2213-3984

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