Assessment of serum β-hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Vijaya M. Revankar, Lavu Narmada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To assess and compare the ability of serum β-human chorionic gonadotropin (β-hCG) and serum lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. Methods: The present hospital-based prospective study was conducted between November 24, 2012, and April 30, 2014, at a tertiary hospital in Mangalore, India. Women of any parity with a pregnancy of 14–20 weeks were included. Venous blood (3 mL) was collected, and serum β-hCG and lipid profile were estimated by enzyme-linked immunosorbent assay and an enzymatic colorimetric test with lipid clearing factor, respectively. A cutoff value of β-hCG for predicting hypertensive disorders was obtained by receiver operating curve analysis. Results: Serum β-hCG was significantly higher among women who subsequently developed hypertension (71 142 IU/L [n=27]) than among those who did not (20 541 IU/L [n=137]; P<0.001). The sensitivity and specificity of serum β-hCG to predict hypertension were 92.6% and 94.9% respectively. The positive and negative predictive values were 78.1% and 98.5%, respectively. Conclusion: Serum β-hCG might be used as a predictor of hypertensive disorders that complicate pregnancy. Dyslipidemia was not found to be a useful marker.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume138
Issue number3
DOIs
Publication statusPublished - 01-09-2017
Externally publishedYes

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Second Pregnancy Trimester
Lipids
Pregnancy
Serum
Hypertension
Chorionic Gonadotropin
Dyslipidemias
Parity
Tertiary Care Centers
India
Enzyme-Linked Immunosorbent Assay
Prospective Studies
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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abstract = "Objective: To assess and compare the ability of serum β-human chorionic gonadotropin (β-hCG) and serum lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. Methods: The present hospital-based prospective study was conducted between November 24, 2012, and April 30, 2014, at a tertiary hospital in Mangalore, India. Women of any parity with a pregnancy of 14–20 weeks were included. Venous blood (3 mL) was collected, and serum β-hCG and lipid profile were estimated by enzyme-linked immunosorbent assay and an enzymatic colorimetric test with lipid clearing factor, respectively. A cutoff value of β-hCG for predicting hypertensive disorders was obtained by receiver operating curve analysis. Results: Serum β-hCG was significantly higher among women who subsequently developed hypertension (71 142 IU/L [n=27]) than among those who did not (20 541 IU/L [n=137]; P<0.001). The sensitivity and specificity of serum β-hCG to predict hypertension were 92.6{\%} and 94.9{\%} respectively. The positive and negative predictive values were 78.1{\%} and 98.5{\%}, respectively. Conclusion: Serum β-hCG might be used as a predictor of hypertensive disorders that complicate pregnancy. Dyslipidemia was not found to be a useful marker.",
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Assessment of serum β-hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy. / Revankar, Vijaya M.; Narmada, Lavu.

In: International Journal of Gynecology and Obstetrics, Vol. 138, No. 3, 01.09.2017, p. 331-334.

Research output: Contribution to journalArticle

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