Assessment of serum L-fucose in brain tumor cases

S. Manjula, Flama Monteiro, Annaya R. Aroor, Suryanarayan Rao, Raja Annaswamy, Anjali Rao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors. Objective: The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor. Materials and Methods: Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride. Results: There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values. Conclusion: Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalAnnals of Indian Academy of Neurology
Volume13
Issue number1
DOIs
Publication statusPublished - 01-01-2010
Externally publishedYes

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Fucose
Brain Neoplasms
Serum
Neoplasms
Glycosylation
Cysteine
Blood Proteins
Glycoproteins
Carbohydrates
Research Personnel

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Manjula, S., Monteiro, F., Aroor, A. R., Rao, S., Annaswamy, R., & Rao, A. (2010). Assessment of serum L-fucose in brain tumor cases. Annals of Indian Academy of Neurology, 13(1), 33-36. https://doi.org/10.4103/0972-2327.61274
Manjula, S. ; Monteiro, Flama ; Aroor, Annaya R. ; Rao, Suryanarayan ; Annaswamy, Raja ; Rao, Anjali. / Assessment of serum L-fucose in brain tumor cases. In: Annals of Indian Academy of Neurology. 2010 ; Vol. 13, No. 1. pp. 33-36.
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Manjula, S, Monteiro, F, Aroor, AR, Rao, S, Annaswamy, R & Rao, A 2010, 'Assessment of serum L-fucose in brain tumor cases', Annals of Indian Academy of Neurology, vol. 13, no. 1, pp. 33-36. https://doi.org/10.4103/0972-2327.61274

Assessment of serum L-fucose in brain tumor cases. / Manjula, S.; Monteiro, Flama; Aroor, Annaya R.; Rao, Suryanarayan; Annaswamy, Raja; Rao, Anjali.

In: Annals of Indian Academy of Neurology, Vol. 13, No. 1, 01.01.2010, p. 33-36.

Research output: Contribution to journalArticle

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Manjula S, Monteiro F, Aroor AR, Rao S, Annaswamy R, Rao A. Assessment of serum L-fucose in brain tumor cases. Annals of Indian Academy of Neurology. 2010 Jan 1;13(1):33-36. https://doi.org/10.4103/0972-2327.61274