Assessment of serum L-fucose in brain tumor cases

S. Manjula, Flama Monteiro, Annaya R. Aroor, Suryanarayan Rao, Raja Annaswamy, Anjali Rao

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors. Objective: The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor. Materials and Methods: Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride. Results: There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values. Conclusion: Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalAnnals of Indian Academy of Neurology
Volume13
Issue number1
DOIs
Publication statusPublished - 01-01-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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