Association of cigarette smoking with superoxide dismutase enzyme levels in subjected with chonic periodontitis

Rupall Agnihotri, Pratibha Pandurang, Shobha U. Kamath, Rahul Goyal, Suhas Ballal, Ashwim Y. Shanbhogue, Ullas Kamath, G. Subraya Bhat, K. Mahalinga Bhat

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Smoking, which is an important risk factor for periodontitis, induces oxidative stress in the body and causes an imbalance between reactive oxygen species (ROS) and antioxidants, such as superoxide dismutase (SOD), In the present study, the influence of smoking on the periodontium was determined by estimating the levels of SOD in light and heavy smokers with periodontitis. Methods: Seventy subjects in the age range of 20 to 55 years, including 60 smokers and 10 non-smokers (controls), were selected. Clinical parameters recorded were plaque index (PI), probing depth (PD), and attachment loss (AL). Smokers were divided into light smokers (<10 cigarettes/ day) and heavy smokers (>10 cigarettes/day) and into three subgroups: healthy, mild periodontitis, and moderate periodontitis. Gingival crevicular fluid (GCF) and saliva samples were collected. SOD levels were analyzed using spectrophoto-metric assay. Results: The mean levels of SOD in the GCF and saliva of smokers were decreased compared to controls. Intra- and in-tergroup analyses showed a significant reduction in the levels of SOD in the GCF and saliva of heavy smokers compared to light smokers and the control group. Conclusions: There was a progressive reduction in SOD levels from healthy non-smokers to light smokers to heavy smokers. These findings highlight the need to augment the efforts of smoking-cessation programs. The benefits of reduced smoking and improved antioxidant levels may motivate smoking cessation.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalJournal of Periodontology
Volume80
Issue number4
DOIs
Publication statusPublished - 01-04-2009

Fingerprint

Periodontitis
Superoxide Dismutase
Smoking
Gingival Crevicular Fluid
Enzymes
Saliva
Smoking Cessation
Antioxidants
Periodontium
Tobacco Products
Reactive Oxygen Species
Oxidative Stress
Light
Control Groups

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Agnihotri, Rupall ; Pandurang, Pratibha ; Kamath, Shobha U. ; Goyal, Rahul ; Ballal, Suhas ; Shanbhogue, Ashwim Y. ; Kamath, Ullas ; Bhat, G. Subraya ; Bhat, K. Mahalinga. / Association of cigarette smoking with superoxide dismutase enzyme levels in subjected with chonic periodontitis. In: Journal of Periodontology. 2009 ; Vol. 80, No. 4. pp. 657-662.
@article{3c4c7e0340b7400daed1b1ada9aba249,
title = "Association of cigarette smoking with superoxide dismutase enzyme levels in subjected with chonic periodontitis",
abstract = "Background: Smoking, which is an important risk factor for periodontitis, induces oxidative stress in the body and causes an imbalance between reactive oxygen species (ROS) and antioxidants, such as superoxide dismutase (SOD), In the present study, the influence of smoking on the periodontium was determined by estimating the levels of SOD in light and heavy smokers with periodontitis. Methods: Seventy subjects in the age range of 20 to 55 years, including 60 smokers and 10 non-smokers (controls), were selected. Clinical parameters recorded were plaque index (PI), probing depth (PD), and attachment loss (AL). Smokers were divided into light smokers (<10 cigarettes/ day) and heavy smokers (>10 cigarettes/day) and into three subgroups: healthy, mild periodontitis, and moderate periodontitis. Gingival crevicular fluid (GCF) and saliva samples were collected. SOD levels were analyzed using spectrophoto-metric assay. Results: The mean levels of SOD in the GCF and saliva of smokers were decreased compared to controls. Intra- and in-tergroup analyses showed a significant reduction in the levels of SOD in the GCF and saliva of heavy smokers compared to light smokers and the control group. Conclusions: There was a progressive reduction in SOD levels from healthy non-smokers to light smokers to heavy smokers. These findings highlight the need to augment the efforts of smoking-cessation programs. The benefits of reduced smoking and improved antioxidant levels may motivate smoking cessation.",
author = "Rupall Agnihotri and Pratibha Pandurang and Kamath, {Shobha U.} and Rahul Goyal and Suhas Ballal and Shanbhogue, {Ashwim Y.} and Ullas Kamath and Bhat, {G. Subraya} and Bhat, {K. Mahalinga}",
year = "2009",
month = "4",
day = "1",
doi = "10.1902/jop.2009.080545",
language = "English",
volume = "80",
pages = "657--662",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "4",

}

Association of cigarette smoking with superoxide dismutase enzyme levels in subjected with chonic periodontitis. / Agnihotri, Rupall; Pandurang, Pratibha; Kamath, Shobha U.; Goyal, Rahul; Ballal, Suhas; Shanbhogue, Ashwim Y.; Kamath, Ullas; Bhat, G. Subraya; Bhat, K. Mahalinga.

In: Journal of Periodontology, Vol. 80, No. 4, 01.04.2009, p. 657-662.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of cigarette smoking with superoxide dismutase enzyme levels in subjected with chonic periodontitis

AU - Agnihotri, Rupall

AU - Pandurang, Pratibha

AU - Kamath, Shobha U.

AU - Goyal, Rahul

AU - Ballal, Suhas

AU - Shanbhogue, Ashwim Y.

AU - Kamath, Ullas

AU - Bhat, G. Subraya

AU - Bhat, K. Mahalinga

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background: Smoking, which is an important risk factor for periodontitis, induces oxidative stress in the body and causes an imbalance between reactive oxygen species (ROS) and antioxidants, such as superoxide dismutase (SOD), In the present study, the influence of smoking on the periodontium was determined by estimating the levels of SOD in light and heavy smokers with periodontitis. Methods: Seventy subjects in the age range of 20 to 55 years, including 60 smokers and 10 non-smokers (controls), were selected. Clinical parameters recorded were plaque index (PI), probing depth (PD), and attachment loss (AL). Smokers were divided into light smokers (<10 cigarettes/ day) and heavy smokers (>10 cigarettes/day) and into three subgroups: healthy, mild periodontitis, and moderate periodontitis. Gingival crevicular fluid (GCF) and saliva samples were collected. SOD levels were analyzed using spectrophoto-metric assay. Results: The mean levels of SOD in the GCF and saliva of smokers were decreased compared to controls. Intra- and in-tergroup analyses showed a significant reduction in the levels of SOD in the GCF and saliva of heavy smokers compared to light smokers and the control group. Conclusions: There was a progressive reduction in SOD levels from healthy non-smokers to light smokers to heavy smokers. These findings highlight the need to augment the efforts of smoking-cessation programs. The benefits of reduced smoking and improved antioxidant levels may motivate smoking cessation.

AB - Background: Smoking, which is an important risk factor for periodontitis, induces oxidative stress in the body and causes an imbalance between reactive oxygen species (ROS) and antioxidants, such as superoxide dismutase (SOD), In the present study, the influence of smoking on the periodontium was determined by estimating the levels of SOD in light and heavy smokers with periodontitis. Methods: Seventy subjects in the age range of 20 to 55 years, including 60 smokers and 10 non-smokers (controls), were selected. Clinical parameters recorded were plaque index (PI), probing depth (PD), and attachment loss (AL). Smokers were divided into light smokers (<10 cigarettes/ day) and heavy smokers (>10 cigarettes/day) and into three subgroups: healthy, mild periodontitis, and moderate periodontitis. Gingival crevicular fluid (GCF) and saliva samples were collected. SOD levels were analyzed using spectrophoto-metric assay. Results: The mean levels of SOD in the GCF and saliva of smokers were decreased compared to controls. Intra- and in-tergroup analyses showed a significant reduction in the levels of SOD in the GCF and saliva of heavy smokers compared to light smokers and the control group. Conclusions: There was a progressive reduction in SOD levels from healthy non-smokers to light smokers to heavy smokers. These findings highlight the need to augment the efforts of smoking-cessation programs. The benefits of reduced smoking and improved antioxidant levels may motivate smoking cessation.

UR - http://www.scopus.com/inward/record.url?scp=63849269592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63849269592&partnerID=8YFLogxK

U2 - 10.1902/jop.2009.080545

DO - 10.1902/jop.2009.080545

M3 - Article

C2 - 19335086

AN - SCOPUS:63849269592

VL - 80

SP - 657

EP - 662

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 4

ER -