Association of family history and consanguinity with permanent hearing impairment

Heramba Ganapathy Selvarajan, Ravi Kumar Arunachalam, Rajashekar Bellur, Kalyani Mandke, Roopa Nagarajan

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Background: Risk factors for hearing impairment can offer important information for both the family and health-care providers regarding etiology, other associated health problems, and risk of recurrence in sub-sequent pregnancy. Family history and consanguinity indicates the possible involvement of genetic factors. Objective: The aim of the study is to find the strength of association of family history and consanguinity with permanent hearing impairment in infants. Materials and Methods: A case-control study was designed on 420 infants with permanent hearing impairment and normal hearing from the year 2008 to 2012. The case control ratio was 1:1. Alternate sampling method was used in a hospital for selecting the control group. Parent interview was carried out to collect the information of family history of hearing impairment and consanguineous marriage. Results: Family history and consanguinity was seen in 18.6% and 39.5% of the hearing-impaired group. These factors were associated with hearing impairment with a high significance (odds ratio (OR) 6.5; 95% Confidence interval (CI) 2.8, 15.1; P = 0.000 and OR: 2.7; 95% CI 1.9-3.9; P = 0.000). The combination of risk-factors is seen in 10% of the hearing-impaired group, whereas only 0.5% had it in the control group. Conclusion: Family history and consanguinity seems to be an important risk factor of hearing impairment both in isolation and in combination.

    Original languageEnglish
    Pages (from-to)62-65
    Number of pages4
    JournalIndian Journal of Otology
    Volume19
    Issue number2
    DOIs
    Publication statusPublished - 01-04-2013

    Fingerprint

    Consanguinity
    Hearing Loss
    Hearing
    Odds Ratio
    Confidence Intervals
    Control Groups
    Family Health
    Marriage
    Health Personnel
    Case-Control Studies
    Interviews
    Recurrence
    Pregnancy
    Health

    All Science Journal Classification (ASJC) codes

    • Otorhinolaryngology

    Cite this

    Selvarajan, H. G., Arunachalam, R. K., Bellur, R., Mandke, K., & Nagarajan, R. (2013). Association of family history and consanguinity with permanent hearing impairment. Indian Journal of Otology, 19(2), 62-65. https://doi.org/10.4103/0971-7749.113510
    Selvarajan, Heramba Ganapathy ; Arunachalam, Ravi Kumar ; Bellur, Rajashekar ; Mandke, Kalyani ; Nagarajan, Roopa. / Association of family history and consanguinity with permanent hearing impairment. In: Indian Journal of Otology. 2013 ; Vol. 19, No. 2. pp. 62-65.
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    abstract = "Background: Risk factors for hearing impairment can offer important information for both the family and health-care providers regarding etiology, other associated health problems, and risk of recurrence in sub-sequent pregnancy. Family history and consanguinity indicates the possible involvement of genetic factors. Objective: The aim of the study is to find the strength of association of family history and consanguinity with permanent hearing impairment in infants. Materials and Methods: A case-control study was designed on 420 infants with permanent hearing impairment and normal hearing from the year 2008 to 2012. The case control ratio was 1:1. Alternate sampling method was used in a hospital for selecting the control group. Parent interview was carried out to collect the information of family history of hearing impairment and consanguineous marriage. Results: Family history and consanguinity was seen in 18.6{\%} and 39.5{\%} of the hearing-impaired group. These factors were associated with hearing impairment with a high significance (odds ratio (OR) 6.5; 95{\%} Confidence interval (CI) 2.8, 15.1; P = 0.000 and OR: 2.7; 95{\%} CI 1.9-3.9; P = 0.000). The combination of risk-factors is seen in 10{\%} of the hearing-impaired group, whereas only 0.5{\%} had it in the control group. Conclusion: Family history and consanguinity seems to be an important risk factor of hearing impairment both in isolation and in combination.",
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    Selvarajan, HG, Arunachalam, RK, Bellur, R, Mandke, K & Nagarajan, R 2013, 'Association of family history and consanguinity with permanent hearing impairment', Indian Journal of Otology, vol. 19, no. 2, pp. 62-65. https://doi.org/10.4103/0971-7749.113510

    Association of family history and consanguinity with permanent hearing impairment. / Selvarajan, Heramba Ganapathy; Arunachalam, Ravi Kumar; Bellur, Rajashekar; Mandke, Kalyani; Nagarajan, Roopa.

    In: Indian Journal of Otology, Vol. 19, No. 2, 01.04.2013, p. 62-65.

    Research output: Contribution to journalArticle

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    AU - Mandke, Kalyani

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