Association of plasma level of thiobarbituric acid reactive substances with extent of hepatocellular injury in preterm infants with cholestatic jaundice

Rinchen D. Bhutia, Bhumika Upadhyay, M. Maneesh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (<35 weeks gestation) admitted to the neonatal intensive care unit were enrolled (with their parents informed consent) in either the 'cholestasis' group (if their direct bilirubin was >2 mg/dl) (n = 25) or in the control group (n = 16). Blood samples for measurement of TBARS, direct bilirubin and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92; P<0.0001) and SGPT (F=355.17; P<0.0001) and differed significantly between cholestatic and control infants. Our findings suggest that oxidative stress in preterm infants with cholestasis is associated with hepatocellular injury.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalIndian Journal of Clinical Biochemistry
Volume21
Issue number2
DOIs
Publication statusPublished - 21-11-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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