Association of plasma level of thiobarbituric acid reactive substances with extent of hepatocellular injury in preterm infants with cholestatic jaundice

Rinchen D. Bhutia, Bhumika Upadhyay, M. Maneesh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (<35 weeks gestation) admitted to the neonatal intensive care unit were enrolled (with their parents informed consent) in either the 'cholestasis' group (if their direct bilirubin was >2 mg/dl) (n = 25) or in the control group (n = 16). Blood samples for measurement of TBARS, direct bilirubin and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92; P<0.0001) and SGPT (F=355.17; P<0.0001) and differed significantly between cholestatic and control infants. Our findings suggest that oxidative stress in preterm infants with cholestasis is associated with hepatocellular injury.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalIndian Journal of Clinical Biochemistry
Volume21
Issue number2
DOIs
Publication statusPublished - 21-11-2006
Externally publishedYes

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Obstructive Jaundice
Thiobarbituric Acid Reactive Substances
Cholestasis
Premature Infants
Aspartate Aminotransferases
Alanine Transaminase
Plasmas
Bilirubin
Wounds and Injuries
Oxidative stress
Transaminases
Blood
Control Groups
Association reactions
Apgar Score
Birth Weight
Gestational Age
Oxidative Stress
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (<35 weeks gestation) admitted to the neonatal intensive care unit were enrolled (with their parents informed consent) in either the 'cholestasis' group (if their direct bilirubin was >2 mg/dl) (n = 25) or in the control group (n = 16). Blood samples for measurement of TBARS, direct bilirubin and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92; P<0.0001) and SGPT (F=355.17; P<0.0001) and differed significantly between cholestatic and control infants. Our findings suggest that oxidative stress in preterm infants with cholestasis is associated with hepatocellular injury.",
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Association of plasma level of thiobarbituric acid reactive substances with extent of hepatocellular injury in preterm infants with cholestatic jaundice. / Bhutia, Rinchen D.; Upadhyay, Bhumika; Maneesh, M.

In: Indian Journal of Clinical Biochemistry, Vol. 21, No. 2, 21.11.2006, p. 39-41.

Research output: Contribution to journalArticle

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