Association of sepsis with iron overload in hemodialysis patients receiving intravenous iron therapy

Gopu Chinnapu Reddy, Ramakrishna Devaki, Pragna Rao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intravenous (IV) iron used to treat anemia of Chronic Kidney Disease (CKD) in Hemodialyzed (HD) patients, may lead to iron overload. The incidence of sepsis in CKD patients with iron overload was studied. Procalcitonin and pro-inflammatory cytokines were used as markers. Serum procalcitonin was estimated semi quantitatively and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were quantified by ELISA. The study groups comprised of CKD patients on hemodialysis, receiving IV iron (n = 33) and CKD patients not on hemodialysis and receiving oral iron therapy (n = 36). Among patients receiving IV iron and on HD, non-survivors had significant (p<0.05) iron overload. 36.7% of HD patients had hyperferritinemia (>800 ng mL-1. Among them, those having PCT>10 ng mL -1, had a mortality of 67%. Elevated interleukin-6 and tumor necrosis factor-a were associated with higher rates of mortality. Iron overload is an additional risk factor propagating sepsis in hemodialyzed patients.

Original languageEnglish
Pages (from-to)252-262
Number of pages11
JournalAsian Journal of Biochemistry
Volume6
Issue number3
DOIs
Publication statusPublished - 2011

Fingerprint

Iron Overload
Renal Dialysis
Sepsis
Iron
Chronic Renal Insufficiency
Calcitonin
Interleukin-6
Therapeutics
Cytokines
Mortality
Interleukin-1
Anemia
Tumor Necrosis Factor-alpha
Enzyme-Linked Immunosorbent Assay
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biochemistry, medical

Cite this

Reddy, Gopu Chinnapu ; Devaki, Ramakrishna ; Rao, Pragna. / Association of sepsis with iron overload in hemodialysis patients receiving intravenous iron therapy. In: Asian Journal of Biochemistry. 2011 ; Vol. 6, No. 3. pp. 252-262.
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abstract = "Intravenous (IV) iron used to treat anemia of Chronic Kidney Disease (CKD) in Hemodialyzed (HD) patients, may lead to iron overload. The incidence of sepsis in CKD patients with iron overload was studied. Procalcitonin and pro-inflammatory cytokines were used as markers. Serum procalcitonin was estimated semi quantitatively and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were quantified by ELISA. The study groups comprised of CKD patients on hemodialysis, receiving IV iron (n = 33) and CKD patients not on hemodialysis and receiving oral iron therapy (n = 36). Among patients receiving IV iron and on HD, non-survivors had significant (p<0.05) iron overload. 36.7{\%} of HD patients had hyperferritinemia (>800 ng mL-1. Among them, those having PCT>10 ng mL -1, had a mortality of 67{\%}. Elevated interleukin-6 and tumor necrosis factor-a were associated with higher rates of mortality. Iron overload is an additional risk factor propagating sepsis in hemodialyzed patients.",
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Association of sepsis with iron overload in hemodialysis patients receiving intravenous iron therapy. / Reddy, Gopu Chinnapu; Devaki, Ramakrishna; Rao, Pragna.

In: Asian Journal of Biochemistry, Vol. 6, No. 3, 2011, p. 252-262.

Research output: Contribution to journalArticle

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AU - Reddy, Gopu Chinnapu

AU - Devaki, Ramakrishna

AU - Rao, Pragna

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